Gordon Matthewson

The precipitous drop in number of emails I need to pay attention to as a post-interview season but pre-match medical student feels a bit like being in the eye of a hurricaine. I'll take it

I'll look forward to it! Thanks

Anyone have a link to an open access version? The MIT link is not working

Large Language Models lack essential metacognition for reliable medical reasoning - Nature Communications Large Language Models demonstrate expert-level accuracy in medical exams, supporting their potential inclusion in healthcare settings. Here, authors reveal that their metacognitive abilities are under...

Metacognition of medical knowledge in LLMs: “Models consistently failed to recognize their knowledge limitations and provided confident answers even when correct options were absent.”

www.nature.com/articles/s41...

A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...

Mapping Lesions That Cause Psychosis This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

jamanetwork.com/journals/jam...
Thread below👇

Don't despair! Organize

I hope you will all join me in expressing your thanks to the NIH and NSF staff who are working in an impossibly difficult and chaotic environment to keep science going in our country.

Lol I feel like this is something Elon would re-tweet and be like "🧐 Looking into this!"

US drug agency approves potent painkiller — the first non-opioid in decades The FDA’s nod for suzetrigine bolsters confidence in the pharmaceutical industry’s strategy to target sodium channels.

US drug agency approves potent painkiller — the first non-opioid in decades

#MedSky 🧪
@nature.com

www.nature.com/articles/d41...

A temperature-inducible protein module for control of mammalian cell fate - Nature Methods The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...

Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation - npj Parkinson's Disease npj Parkinson's Disease - Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation

A collaborative #openaccess review on how electrophysiological brain recording and imaging at multiple scales, from cells to large-scale brain networks, contribute to defining neurostimulation targets. #parkinson

www.nature.com/articles/s41...

Would you happen to have any intro papers abt chemical exchange between blood here and csf? Honestly i think this is a big part of homeostasis that is understudied no worries if not

Super cool!!

Not trying to gotcha, seriously: what does IQ mean and what does it measure

Lol the fact that this is what's causing this thread to blow up (in addition to great hot dogs) is case in point

Pics or it didn't happen

Reading these with a cup of coffee now

Love it. Thanks!!

Booooooooooo

Bot

Also this is a bot

Awesome photo, water looks a little AI?

Interesting - any chance you have a primer on inflammatory complexes? I need to get up on that no worries if not

Literally waiting in line for one of these rn

If/when I can afford a house, maybe moving to Pennsylvania, western New York, or Minnesota? shh #climatechange

Send it!

Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.

Honey, stop what you're doing, new hyponatremia research just dropped!

What's it say?

It looks like slow correction is associated with worse outcomes, like death and length of stay!

Was it just a small study?

No, it was a meta-analysis of almost 12,000 patients!

jamanetwork.com/journals/jam...

SUPER excited to share this opening for a senior (Assoc/Full) Professor of Psychiatry + endowed Chair at Dartmouth! You: a translational research scientist using imaging (fMRI, fNIRS, fUS) and/or neurostimulation (TMS, tTIS, tACS/DCS, tFUS). Please apply and repost!
tinyurl.com/dartmouthneuro