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Ha Nguyen

@hanguyen07.bsky.social

PhD candidate | Farías lab | Utrecht University. NEURASMUS alumni 🇪🇺. Neurobiologist in training. Microscopy enthusiast 🔬. Interested in anything ER related, protein sorting, local translation and synaptic plasticity.

69 Followers  |  124 Following  |  8 Posts  |  Joined: 15.11.2024  |  1.7493

Latest posts by hanguyen07.bsky.social on Bluesky

Yes, it is likely that ECM proteins could use this mechanism. It would be interesting to check this further. Very interesting comment. Thanks!

15.09.2025 14:39 — 👍 0    🔁 0    💬 1    📌 0
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Wow, this paper provides crucial understanding of local translation and processing of transmembrane proteins in axons, one of the big mysteries that have haunted the field for a long time!!!!!!!! Fantastic!!!!!!!! Nguyen et al., 2025, bioRxiv 2025.09.09.674816ff. -- doi.org/10.1101/2025...

14.09.2025 18:12 — 👍 61    🔁 18    💬 3    📌 1

Thank you for sharing our work and for the kind words!

15.09.2025 13:25 — 👍 0    🔁 0    💬 1    📌 0

Huge thanks to Ginny Farías for the feedback and to all co-authors @noortjekersten.bsky.social, Chun Hei Li, Huey de Jong, Tanuj Arora, Themis Liolios, Mai Dan Nguyen, @mpbebelman.bsky.social, Maarten Altelaar, and @maxkoppers.bsky.social for the collaborative work!

10.09.2025 07:18 — 👍 3    🔁 0    💬 0    📌 0

4) We identified the ER-translation regulator HDLBP and the NRZ-SEC22B tethering complex associated with axonal ERES and involved in unconventional secretion. Local removal of axonal ERES components or depletion of these identified players causes defects in axon development.

10.09.2025 07:18 — 👍 2    🔁 0    💬 1    📌 0
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3) We identified axonal ER-exit-sites components tightly associated with the axonal ER. We developed a tool for local removal of axonal ERES components and observed a reduction in the number of Golgi-bypassing cargos in the axon.

10.09.2025 07:18 — 👍 2    🔁 0    💬 1    📌 1
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2) Using the Retention Using Selective Hook (RUSH) tool with axonal ER hook, in combination with photoablation, we observed that TMPs can be locally secreted from the axonal ER.

10.09.2025 07:18 — 👍 1    🔁 0    💬 1    📌 0
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1) We observed translation of axonal TMPs occurring along the axon. Therefore, we wondered if these proteins could be locally secreted.

10.09.2025 07:18 — 👍 1    🔁 0    💬 1    📌 0
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Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.1.... We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

10.09.2025 07:18 — 👍 28    🔁 14    💬 1    📌 2

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