AnnaLin Woo

Can Ketamine Stop Deadly Epilepsy Seizures? UVA has received $9.3 million to test if ketamine can save patients from grand mal seizures that won’t respond to other treatments.

One of UVA's clinician researchers is also heading up a big grant looking at using ketamine as seizure treatment newsroom.uvahealth.com/2025/01/29/c...

I wish I had more & better info for you. Do you have any local communities or groups that you can lean on as well?

That is incredibly rough, I am sorry to hear it. I know Mayo Clinic has been working on some regenerative therapy techniques that they are hopeful about: newsnetwork.mayoclinic.org/discussion/m...

Table shows number of deaths from heart disease, respiratory distress, diabetes, cancer, stroke, Alzheimer’s drug overdose, suicide, Covid/flu. For each condition, they list the institute they funds that research and the amount of proposed funding cuts. These range from 36% to 40%

Making America Healthy Again by defunding research on cancer, diabetes, and Alzheimer’s is an…interesting, and reckless, strategy

www.nytimes.com/interactive/...

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models o...

...a bit of a "chicken vs egg" question!

You can find this open-access article here: doi.org/10.1111/epi....

Many thanks to my co-authors and all of the supportive folks that have been involved!

#epilepsy #epilepsia #ecm #matrix #perineuronalnets #pnns #neuroscience

(5/5)

Interneurons are the "brakes" of the brain, balancing out excitatory activity. If they are are more active in our model, they could be forming nets to try to balance overexcitation, or the nets could be forming due to increased activity...

(4/5)

... which can lead to future seizures and developing epilepsy, but exactly what happens is not fully known.

These interneurons developing new nets makes them more excitable in our model- so the neurons are firing more than w/o nets, which is both exciting and new!

(3/5)

...a long and severe seizure episode called "status epilepticus". This matters a lot because as of right now, the process of developing epilepsy is still... well, sort of a black box!

We know there are changes going on in the brain after an injury...

(2/5)

"Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus" is now out in Epilepsia!

🤔What's in it, you ask?

We found interneurons in the mouse hippocampus develop new matrix structures called perineuronal nets after undergoing...

(1/5)

Hi friends- if you're interested in what I've been doing for the last 6+ years, I'm defending my dissertation on July 11th at 11am! Come tune in on zoom (message me for the link!) to hear about why we think matrix structures called #perineuronalnets are important in seizing mice.

The Da Vinci load: Leonardo's packing list revealed Renaissance artist and anatomist needed pane of glass, forceps and a bone saw, a page from his notebook reveals

I found an image of the notebook in this Guardian article, though I can't read it! www.theguardian.com/artanddesign...

I have learned that the directors of ALL: PREP, IMSD, and IRACDA programs across the country have received similar cancelation notices. This follows previous cancellations of MARC and URISE programs. This further dismantles the mechanisms that enable scientific training opportunities for SO MANY.

You do not need a lawyer to file your appeal. You must not delay filing because you want to find a lawyer to represent you – you will lose your claims if you do not file on or before the deadline. (4/4)

Here is how you file an appeal www.mspb.gov/appeals/appe... And here is where you file an appeal online: e-appeal.mspb.gov/etk-mspb.../... (3/4)

The time limit to appeal is 30 days from the effective date of your termination or the date you received the Agency’s decision, whichever is later. (2/3)

MSPB appeal rights:
If you have been terminated, whatever that termination was called (“termination,” “removal,” “RIF”), you may have the right to appeal that termination to the Merit Systems Protection Board ((www.mspb.gov ); and see www.mspb.gov/appeals/appe...). (1/3)

A friend with a neuro BS went into nursing! Some went to grad school (me included); 1 went on to work as a counselor/ in social work (started with BS and went on to do a master's eventually); similarly another into gene therapy; & some went a completely different direction in coding & finance!

It may not be cool or hip in some circles, but we legitimately do need a massive amount of people to run for office.

Flood the school boards, councils, county seats, state legislatures, Congress, etc.

Big changes at the top happen when the ground shifts at the bottom. And that can start now.

Neuroscientists - your society has a call to action for you and a page for tracking action alerts.

It's built to take your location & give you specific support on what to say and who to say it to. www.sfn.org/Advocacy/Adv...

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed. Any unpublished manuscript mentioning certain topics, including gender and "LGBT," must be pulled or revised.

BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed.

Goes beyond MMWR +other CDC pubs. Applies to research already submitted to top medical journals.

Take a look.
open.substack.com/pub/insideme...

Keep sharing your JOY ✨

Keep celebrating your PhD defenses, job offers, and awards! Keep telling us ALL the good things.

Joy & Hope are what keep us going when things look bleak. They are also forms of resistance.

We can beat them. That's the secret. The bluster now? All meant to keep you from realizing your own power and agency. end/

Organize. Organize. Organize. In your neighborhood. In your city or town. Your state. But do not sit on the sidelines now. 10/

What the Hell Is Going on at NIH? Scientists sound the alarm about Trump’s unprecedented “Big Brother” research crackdown.

Really thankful to all of the scientists who made themselves available to talk to me about the unprecedented situation at NIH.

I've never had so many people reach out to me for a story like this.
www.motherjones.com/politics/202...

Are you affected by the Trump administration’s pause on health communications, science meetings, and reviews? Have you been affected by the Trump administration’s pause on communications, science meetings, and reviews? @statnews would like to hear from you.

Is the communications pause that's been imposed on the US government's health agencies affecting you? @statnews.com would love to hear about it. Please let us know. www.statnews.com/2025/01/25/t...

Pasteurisation temperatures effectively inactivate influenza A viruses in milk - Nature Communications In response to the emergence of H5N1 influenza A viruses as a novel pathogen of cattle, this study shows that pasteurisation of cows’ milk should effectively inactivate the virus, but that it remains ...

Pasteurization temperatures inactivate #H5N1 effectively. We know that raw milk contains replicating virus and can a source of infection for this virus.
#RFKJr is a raw milk enthusiast who should not lead HHS esp NOT in the middle of an uncontrolled #H5N1 outbreak.
www.nature.com/articles/s41...

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

Virginia trans rights, health, and support groups:
www.sidebysideva.org
www.shenlgbtqcenter.org
powersafeplace.org

Charlottesville specific groups:
www.cvillepride.org
www.pflagcville.org
www.onourowncville.org