Anup Parchure

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

A new set of very cool results in support of cisternal maturation of the Golgi apparatus. It is very intriguing that the debate is ongoing with new approaches.

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

Mechanical forces stimulate Golgi export Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Very cool story. There was a paper a couple of years back on links between mechanical signaling and regulation of sec23a and b. Wondering what happens to the secretory flux from er to golgi when you block golgi export.

Congratulations

Important.......

Programme Leader Track - MRC Laboratory of Medical Sciences We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease.

It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us!

lms.mrc.ac.uk/work/vacanci...

Thanks, Mike

Role of clathrin adaptor complex AP3 in secretion of dense core vesicles from the Sahu lab, NBRC.

Badal from my lab has added an experiment testing the role of AP3 in secretion of neuropeptides in C. elegans.

An important piece of my postdoctoral work now out. My first entry into the early secretory pathway regulation had many interesting surprises. Thanks for the collaboration @ishier.bsky.social. The deflects in collagen secretion really elevated the paper.

Farewell America. I am leaving with many new deep connections and bonds. I couldn't be more content and thrilled about my postdoctoral work especially with positive news about a manuscript in the last few days. Hopefully a new chapter in my life will begin soon. Now back to applications 😀.

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion Sue et al. show that ER stress impairs insulin secretion by misplacement of permissive proteins from the plasma membrane. This results from defects in the retromer and the constitutive secretory pathway. Thus, in type 2 diabetes, ER stress mediates β cell dysfunction, not just loss of β cell mass.

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

Call for Group leaders in Innovative Biology Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Call for Group leaders in Innovative Biology #ScienceJobs #AcademicSky jobrxiv.org/job/mont...

Condensates drive insulin granule biogenesis

Excited to present our unpublished data tomorrow on how Mechanosesing at the Endoplasmic Reticulum regulates Proteostasis. #Organelles #Mechanobiology

We will recruit PhD candidates through @fmiscience.bsky.social call due on May1. If you are interested in stem cell biology/ cancer biology and using either imaging or "omics" tools to study metabolism in vivo , please check out the talk and come meet me after.

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>

Excited to share that IBDM (Institut de Biologie du Développement de Marseille) is expanding its research groups this year! A great place for developmental biology and interdisciplinary research located on the beautiful Marseille-Luminy campus!
Deadline for applications: March 30th, 2025

6 more weeks to apply !

Become our new colleague at the Cell Biology Dpt and join the growing group of junior teams of @i2bcparissaclay.bsky.social shaping the scientific environment of the institute.

Apply if you are looking for a place to start a lab or forward to any potential candidates.

BORC segregates synaptic vesicle and lysosomal proteins through motors UNC-104/KIF1A and UNC-116/KIF5 https://www.biorxiv.org/content/10.1101/2024.12.31.630845v1

We recently tried using mEOS3.2 as a photoconvertible tag. Unfortunately our protein of interest is very low in abundance and barely visible. Are there brighter photoconvertible tags that are known to work is yeasts? #microscopy #yeast #cellbiology #imaging

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

www.nature.com/articles/s42....

This one. Very cool. Solves a long standing mystery in protein sorting at the TGN but then has a major twist.

Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob

There is a receptor for proinsulin at the TGN (finally after the search was on forever), but with a twist. It targets proinsulin to the lysosomes and not to the secretory granules. Interesting biology. This would probably represent the excess proinsulin which escapes Chronogranin condensates.

Hello folks!
I'm looking for recommendations for antibodies against ER exit site and ERGIC proteins that work for immunofluorescence in mouse fibroblasts.
Bonus internet points and gratitude for anyone who recommends a nice antibody for TANGO1.

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Membrane traffickers: Any good suggestions for a SURF4 antibody for immunostaining in murine cells? If not should detect the murine protein in WB. Any suggestions would be appreciated 🙏.