Robert Fledrich

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

What an outstanding piece of work - congratulations André!

Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies Nature Communications - Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial...

Our paper was just published in Nat Comm. First single‑nucleus atlas of human sural nerves in health and disease. Identified lipid‑phagocytosing macrophages and focal perineurial hyperplasia especially in immune-mediated polyneuropathies. rdcu.be/eB2Dg

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

Now published in the June issue @natneuro.nature.com
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!

Congratulations Janos! And fantastic art work by your little one!

Universität Leipzig: GRK Neurotune

Do you want to explore the molecular secrets of how we adapt and learn?

We are excited to announce the launch of the interdisciplinary Research Training Group NeuroTune.

Applications for 10 PhD positions are now open!

#NeuroTune #DFG #Neuroscience #PhDOpportunities

🚀 Now hiring: 10 Doctoral Researchers @ Leipzig University! 🧠🔬

Join the DFG funded RTG NeuroTune and explore how neurons fine-tune communication!
📍 Start: Oct 1, 2025
🎯 Cutting-edge neuroscience + top-tier mentoring in vibrant Leipzig.

Apply now 👉 www.lw.uni-leipzig.de/en/institut-...
#NeuroTune

Can 2–4 hours of intense exercise really deplete brain myelin by nearly a third? Myelin water fraction isn’t the same as myelin, and this bold claim needs far more evidence. (Good thing marathon runners don’t seem to suffer cognitive issues!)

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells YAP/TAZ-mediated gene transcription is necessary for Schwann cell laminin receptor expression and differentiation. Weaver et al. use transgenic mouse models to show that the STRIPAK complex is required to regulate YAP/TAZ and facilitate radial sorting.…

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

Do women exhibit less cognitive decline because they can better maintain myelin due to Plp expression from the silent X chromosome?

Get On Your Nerves LP (SouthPaw, 2010), by Myelin Sheaths 11 track album

Not sure what mental short circuit made me search for myelin on spotify, but I’m so glad I did. What I found reignited my old love for vinyl and garage punk and took me back to my student days when I had a band like this - ‚The Myelin Sheaths’ to me sound like a beautiful serendipity of fate.

Wrapped up: advancements in volume electron microscopy and application in myelin research The three-dimensional visualization of cellular architecture by volume electron microscopy (vEM) has reignited interest in morphological descriptions of complex tissue. At the same time, the increasin...

Wrapped up: advancements in volume electron microscopy and application in myelin research

Glad to have contributed a bit to this review!

www.degruyter.com/document/doi...

We are excited to present a first large-scale (365,708 nuclei) single cell atlas of human peripheral nerves combined with subcelullar spatial transcriptomics (#Xenium). A

www.biorxiv.org/content/11.1...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/11

Thank you Minou :)

Thank you Gonçalo!

Big thanks!

Thanks Janos!

Thank you!

ERC Consolidator Grant for research on nerve disorders Robert Fledrich, neuroscientist and professor at the Institute of Anatomy at Leipzig University’s Faculty of Medicine, has been awarded an ERC Consolidator Grant by the European Research Council (ERC)...

I'm over the moon to share that I have been awarded an ERC grant! 🎉✨ - can‘t wait to dive into super exiting projects! #ERCCoG

www.uni-leipzig.de/en/newsdetai...

Thank you! 😊

Thank you Pete, I’m really looking forward to seeing you in Kassel!

Thank you Sophie & Yannick, it definitely is! 🎉

Thrilled that the DFG will fund our NeuroTune graduate school in Leipzig with €5.7M, supporting 5 tandem projects creating over 40 PhD positions. The Stassart/Fledrich lab is proud to host two projects, exploring adaptive myelination in diverse contexts. Stay #NeuroTuned for updates!

tiny.cc/3fyvzz

Here’s the #Schwanncell starter pack.

go.bsky.app/TXfQiG

Thank you Ethan! Please add us.

me please. thank you!

Thank you for setting this up! I would be ready to hop on