John Greally

When it comes out, look on www.cshlpress.com

My collaborator @tuuliel.bsky.social is in there. So is @wiringthebrain.bsky.social.

I left a kind of Easter Egg in my mention of @odedrechavi.bsky.social.

It’s not your average dry scientific tome. I’m rude in Finnish in the first paragraph.

As I said, I’m a bit nervous.

My book Epigenetics: History, Molecules and Diseases will be published in exactly one month (September 2).

Finalizing cover (looks great), probably going to printer this week.

Nervous anticipation is the mood right now.

Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀
www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!

Bronx seagull has had enough of your attitude

Fried fish on City Island in the Bronx, at the legendary Johnny’s Reef.

I feel lucky to have such great people working here in my lab and with Sri Raj, and in the @newyorkcrd.bsky.social

@einsteinmededu.bsky.social

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding Oncogene - PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding

More of these studies coming out, showing that post-translational modifications of transcription factors adds another layer of complexity to transcriptional regulation.

www.nature.com/articles/s41...

Yes, our challenge just got bigger, but so did our potential insights.

Reminder! Tenure track position in Genetics at Trinity College Dublin! Come join us, we're nice... 😊 Please repost! 🙏

For what I consider the best inter-generational study to date @jamiehackett.bsky.social used over 2,000 mice.

www.nature.com/articles/s41...

While that's a lot of mice, it is better animal welfare to perform a definitive study than to perform hundreds of uninterpretable studies.

Research Ireland, on behalf of @deptoffhed.bsky.social, have today launched Global Talent Ireland - a new initiative to attract exceptional mid-career and established researchers from across the globe to Ireland.

For more information visit:
www.researchireland.ie/funding/glob...

The difference with Methylation Risk Scores compared with epigenetic aging clocks is that they are designed for disease risk stratification, potentially exceeding the performance of polygenic risk scores.

Whereas a change in your epigenetic clock value is meaningless in terms of your health care.

Methylation risk scores are associated with a collection of phenotypes within electronic health record systems - npj Genomic Medicine npj Genomic Medicine - Methylation risk scores are associated with a collection of phenotypes within electronic health record systems

I'm intrigued by the performance of Methylation Risk Scores from the Zaitlen and Halperin @eranhalperin75.bsky.social groups:
www.nature.com/articles/s41...

It may be that blood cell subtype composition is very sensitive to all sorts of things, including smoking, age and medical conditions.

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...

Probabilistic inference of epigenetic age acceleration from cellular dynamics The emergence of epigenetic predictors was a pivotal moment in geroscience, propelling the measurement and concept of biological aging into a quantitative era; however, while current epigenetic clocks...

More good work from the University of Edinburgh ‪@edinburgh-uni.bsky.social‬

pmc.ncbi.nlm.nih.gov/articles/PMC...

Local CpG density affects the trajectory and variance of age-associated DNA methylation changes DNA methylation is an epigenetic mark associated with the repression of gene promoters. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with ...

If you believe that cells reprogram their transcriptional regulatory mechanisms with age at the same loci across all cell types, what is the mechanism?

Be more like @sproullab.bsky.social and ask better questions:
pmc.ncbi.nlm.nih.gov/articles/PMC...

FaceAge, a deep learning system to estimate biological age from face photographs to improve prognostication: a model development and validation study Our results suggest that a deep learning model can estimate biological age from face photographs and thereby enhance survival prediction in patients with cancer. Further research, including validation...

The sexy DNA methylation/epigenetic component makes clocks sound like serious science.

What if FaceAge were used instead? My guess is that this alternative, comparable biomarker of aging would be dismissed as too intuitively obvious.

www.thelancet.com/journals/lan...

Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial Semaglutide is a once-weekly GLP-1 receptor agonist that has been proposed as a gerotherapeutic, yet no data exist on its effects on epigenetic aging. We therefore conducted a post-hoc epigenetic anal...

For example www.medrxiv.org/content/10.1...

Did we learn anything of practical value?

This field appears to feed on itself -- I applied clocks, I found associations, therefore clocks show associations, therefore more clocks.

Getting out of this loop would involve understanding what clocks mean.

I fail to understand the value of using epigenetic aging clocks in any situation.

They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.

More expensive and less meaningful than a fortune telling machine.

Pioneering alliance between The Jackson Laboratory and The New York Stem Cell Foundation ushers in new era of predictive biomedical research Uniting cutting-edge genomics, stem cell science, and AI-enabled data science to accelerate the discovery of life-changing therapies

Big news for science in NYC

www.jax.org/news-and-ins...

In 50 days, my book Epigenetics: History, Molecules and Diseases will be published by @cshlpress.bsky.social

Nice work David.

I'm not 100% opposed to the points he raises, but this is not the way a newspaper should be generating content.

Why are Irish genetic tests still being sent to laboratories abroad? Tests are often central to clinical decision-making, patient diagnosis and time-sensitive interventions

@irishtimes.com, why are you publishing what is overtly an advertisement under the guise of an 'opinion' piece?

The managing director at Genseq suggests that Ireland should send its genetic tests to "Commercial labs such as Genseq"

www.irishtimes.com/business/202...

How Your Neighborhood Voted in the NYC Mayoral Election Check out this map to see which candidates got the most first-round votes in every election district in New York City.

The map from @thecity.nyc is excellent

www.thecity.nyc/2025/06/24/m...

Representative @aoc.bsky.social clearly has an astute political nose.

Her suggested ranking in the NYC Mayoral primary closely mirrored the outcome.

Such an interesting primary here in #NYC

www.nbcnewyork.com/news/politic...

Get out and vote, NYC.

Happy to help, America!

@doughnutplant.bsky.social doughnuts for the group. A well-fed lab is a happy lab.

If someone has your genomic information, whether in academia or the commercial world, you should control its use.

Control, not trust, is the sustainable model.

Glad I deleted my 23&Me data

www.nytimes.com/2025/06/10/b...