Claire Rougeulle

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

Speakers — Lorne Genome No description found

Last chance! Early bird rates and oral presentation abstract submissions for Lorne Genome 𝐞𝐧𝐝 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 𝟕𝐭𝐡, 𝟐𝟎𝟐𝟓 - only one week away: https://www.lornegenome.org/registrations

We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!

À ne manquer sous aucun prétexte!

#ESMO25 | New insights from the SOHO-01 study presented by Prof. NIcolas Girard @institutcurie.bsky.social:
Molecular factors and ctDNA dynamics may help predict outcomes in patients with HER2-mutant #NSCLC treated with sevabertinib, paving the way for more personalized care.

#medonc #lungcancer

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?

Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...

Professor Fuller is brilliant and you need to read what she has to say.

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

Congrats Charlène!

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

Patterned invagination prevents mechanical instability during gastrulation - Nature In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...

We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)

www.nature.com/articles/s41...
www.nature.com/articles/s41...

The @crick.ac.uk is in good hands! Not that it wasn’t before

The authoritarian checklist It is time to admit that America is no longer a functioning democracy

if you are willing to look clear-eyed at the cumulative evidence, the inescapable conclusion is that our deeply held beliefs about American democracy no longer match our present reality.
donmoynihan.substack.com/p/the-author...

CHAOS ERUPTS AT CDC

CDC Director Susan Monarez has been ousted after RFK Jr. demanded she change her policy on the COVID vaccine. Top officials from the Vaccine Unit, Zoonotic Division, and the Chief Medical Officer are resigning, per reports.

Horrifying news for public health.

Sen Patty Murray (D-WA):

“If there are any adults left in the White House, it’s well past time they face reality… We cannot let RFK Jr. burn what’s left of the CDC and our other critical health agencies to the ground—he must be fired.”

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

Just a few more days left to apply!

📅 Apply by Sept 14 to our International Course “Multiscale integration in Biological Systems” in partnership with @normalesup.bsky.social
👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Wow, maybe genomic imprinting as we know it is just the tip of then iceberg. Hopefully this helps usher in a wave of mechanistic studies www.nature.com/articles/s41...

Want to see the impact of #NIH, #NSF and #EPA grant cuts in your community? Check out @noamross.net, @scott-delaney.bsky.social and colleagues' project here. Tell your friends and neighbors about what is happening. grant-witness.us

Well done Katja!

Excited that our paper was published in Science Advances 🧪
Great work by first author Merrick Pierson Smela who will carry this work forward in his new start-up!

Our institution has given a generous donation as well as our fly labs. Convince yours to do so as well!

Congratulations Ohad !

Sign the IMPEACH RFK Citizens' Petition to Congress — STAND UP FOR SCIENCE Join with us to sign our Citizens' Petition to the US Congress to choose the people over Trump and Impeach RFK Jr Now!

Sign the petition to call for the removal of RFK, Jr.

www.standupforscience.net/rfk-impeachm...

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation | EMBO reports imageimageIn spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin modifications and the binding of DNA methylation-sensitive transcription fac...

Really beautiful work led by Jessica Leismann in Joan Barau’s lab @imbmainz.bsky.social . If you like elegant mouse genetics, the transposon arms race, and a healthy dose of epigenetics, this one’s for you. www.embopress.org/doi/full/10.... @emboreports.org