Claire Rougeulle

Join us in the #institutcurie exceptional environment to explore the mysteries of X chromosome regulation in early human development

🔴 Day 2 at ASCO Meeting |Attending #ASCO25?

Come and meet Institut Curie´s teams! Let’s share insights on our latest clinical research studies and explore new opportunities for collaboration against #cancer 🤝

📍 Institut Curie - Booth 30164 - Hall A

Silent X chromosome awakens with age In aging female mice, genes on the second X chromosome become active again. This could be an explanation for sex differences in aging humans regarding disease.

Why do women experience aging-related diseases differently than men? A new study shows that with age, genes on the inactive X chromosome can reactivate – potentially influencing conditions like #dementia and #autoimmunity: go.tum.de/987255

#genetics #aging

📷 @dandergassen.bsky.social

Rencontre avec un académicien – Les cellules sentinelles du système immunitaire : une exploration scientifique

Avec Ana-Maria Lennon-Dumenil, immunologiste et biologiste cellulaire.

📍 Institut de France – 23 quai de Conti, Paris
🕕 18h-19h | 🕠 Ouverture des portes à 17h30
🎟️ Inscription requise

Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump » Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son ordinateur et son téléphone ne soient fouillés.

Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump »

Soutenue par la Fédération Nationale de la Mutualité Française, l'étude OPTI-DEPIST-MUT est l’une des seules du genre actuellement en cours en France et s’inscrit au cœur de la stratégie décennale de lutte contre le cancer.
#Cancerdupoumon

Pour en savoir plus : curie.fr/opti-depist-...

Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘

Très honorée d’avoir pu donner, avec Nathan, ce coup d’envoi fictif. Toutes et tous mobilisés contre le cancer avec la jonquille de l’Institut Curie @institutcurie.bsky.social

Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee Naive pluripotent stem cells (PSCs) are counterparts of early epiblast in the mammalian embryo. Mouse and human naive PSCs differ in self-renewal requ…

Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee. www.sciencedirect.com/science/arti...

NIH funding cuts could have ‘devastating impact’ on medical advancements, Chicago researchers say The National Institutes of Health under President Donald Trump announced this month that it was cutting payments covering overhead costs for research institutions that receive its grants.

Freezing out the NIH's funding means freezing out American innovation.

Research into curing cancer, Alzheimer's, and Parkinson's all delayed.

And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.

Stoked to share my research journey next week! I'll walk through my PhD work in the lab of @crougeulle.bsky.social on XIST regulation evolution, and a short preview of my current work with @carldeboer.bsky.social at @sbmeubc.bsky.social at the interface of gene regulation, synthetic biology and ML 🧬

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.

www.nature.com/articles/s41...

The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌

Prospective assessment of circulating tumor DNA in patients with metastatic uveal melanoma treated with tebentafusp - Nature Communications Response to tebentafusp is variable in patients with metastatic uveal melanoma. Here, the authors use droplet digital PCR to detect ctDNA and show that ctDNA positivity was associated with shorter ove...

Uveal Melanoma: Researchers at @institutcurie.bsky.social, led by Dr. Manuel Rodrigues, demonstrate the benefits of using circulating tumor DNA (ctDNA) to monitor metastatic uveal melanoma patients on immunotherapy.

Read study published in @naturecomms.bsky.social
▶️ www.nature.com/articles/s41...

Transposable element exonization generates a reservoir of evolving and functional protein isoforms Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.

Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins.
www.cell.com/cell/fulltex...

Join us for the Paris-Munich Epigenetics Workshop & Symposium, April 9-11, 2025, Université Paris Cité.

The symposium is open for experts and newcomers in the field. Newcomers are encouraged to apply for the one-day WORKSHOP, April 9.
See program and registration, free of charge: shorturl.at/mAaWn

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...

A landscape of X-inactivation during human T cell development - Nature Communications X-chromosome inactivation (XCI) contributes to sex bias in T cell immunity, but data on profiling XCI during human T cell development is still lacking. Here, the authors leverage allele-specific expre...

A landscape of X-inactivation during human T cell development www.nature.com/articles/s41...

Enjoy!

Cercle FSER Declics - Dialogue entre Chercheurs et Lycéens pour les Intéresser à la Construction des Savoirs : Des personnels de recherche se déplacent à la rencontre des lycéens, pendant une demi-journée, partou...

🇫🇷Vous faites de la recherche et souhaitez partager votre passion pour la science avec des lyceens? Inscrivez vous a Déclics!
Je cherche encore quelques scientifiques pour participer a une visite le 9 decembre. Rejoignez nous!
www.cerclefser.org/fr/declics/j...

A tantalizing program, as usual

Happy to share our preprint👇
Congrats and thanks to all the co-authors 🙏

📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!

You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.

Please DM me with any questions and help us spread the word 🙏