Chris Brown

A bit late - I have been security link from phenomenex for a few years now.

Thrilled to be collecting data on the 8600 from @sciex.bsky.social

Just collected zt scan on a small molecule and it is beautiful!!

Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer A quadrupole/drift tube ion mobility/Orbitrap instrument requires pumping from atmosphere to 10–5 Torr in the quadrupole analyzer region, back to 1 Torr for the drift tube, and a return to 10–5 Torr for the Orbitrap high vacuum region. The Orbitrap high vacuum region contains the transfer multipole, C-trap, and HCD cell. Insufficient pumping between the drift tube and quadrupole leads to helium in the quadrupole analyzer chamber which compromises performance. Additional vacuum regions were added between the drift tube and the analyzer chamber to maintain the analyzer pressure below 5.5 × 10–5 Torr with the drift tube pressurized to 1.5 Torr of He. In this configuration, the isolation of a single charge state of C-reactive protein (m/z 5,000) was demonstrated. Fourier transform ion mobility spectra were acquired with the quadrupole in full scan mode and in the isolation mode. Ion optic voltages were optimized for both helium and nitrogen bath gases in the drift tube so that minimal ion heating was observed entering the drift tube. These instrument modifications enable improved ion transfer efficiency, allowing for better ion isolation by the digital quadrupole ion mobility separation of large protein complexes, as illustrated by the 23+ and 24+ charge states of C-reactive protein.

Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer #JASMS pubs.acs.org/doi/10.1021/...

20x data increase going from a DDA file to a ztScan

We mainly do analytical flow, but the source seems awesome. Low flow, analytical and APCI super easy

Awesome hang out with folks at Mass Spec Happy Hour

a man in a space suit is looking at a screen that says mission day ALT: a man in a space suit is looking at a screen that says mission day

Just talked with someone that is involved in legal stuff. They said - “we will just amend the shit out of this agreement”!

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Retrospective metabolomics via dual-dimensional deconvolution using ZT Scan DIA 2.0 Herein, we present a scanning data-independent acquisition (DIA) approach (ZT Scan DIA 2.0) combined with dual-dimensional tandem mass spectrometry spectral deconvolution along both the quadrupole and...

We are excited to introduce a novel MS2 data processing workflow in MS-DIAL that extends the capabilities of metabolomics and lipidomics through ZT Scan DIA 2.0.
Details are now available in our preprint:
🔗 www.biorxiv.org/content/10.1...
#metabolomics #lipidomics #massspectrometry #msdial

Hot take here: one tool that fits all it’s probably gonna do less well than the targeted tools. I wonder how much context filtering they do versus the open world format of GPT.

Just signed up! Have you benchmarked it against GPT running the same queries?

Can you share your queries/search terms?

Ep183: Sabah Oney on CAR-T Cells Against Solid Tumors Podcast Episode · The Long Run with Luke Timmerman · 08/06/2025 · 56m

This was a wonderful listen - working towards curing solid tumor cancer, beautiful + synergistic technology (CAR-T and oncolytic viral therapy) and motivation that is patient focused!

podcasts.apple.com/us/podcast/t...

99% of lc-ms systems generated in Biorender are an Ultimate with Tribrid so this opens up some new options :)

Our department is hiring! The Department of Chemistry at the University of Utah invites applicants for two tenure-track faculty positions at all ranks in the areas of 1) Biological Chemistry broadly defined and 2) Experimental Physical Chemistry.

utah.peopleadmin.com/postings/186...

Pretty cool to be recognized for science that I love!! Thanks to @acs.org and our research group for making this happen

Had a great time at Chicago Mass Spec day! Many thanks to the organizers and congrats on the 10 year anniversary!

Also want to highlight our great undergrad intern, Justin Chavez! His first poster at an academic conference went awesome! #teammassspec

Yesterday we had a group of J and A Laskin students on site from Purdue. So fun to catch up and share some industrial analytical chemistry! Big thanks to Nazifa and Jesba for helping to organize! @lablaskin.bsky.social

Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling - Nature Communications To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. ...

New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:

www.nature.com/articles/s41...

Behind the paper story:
go.nature.com/45ljV4d

a picture of a dinosaur with the words yaaaaaaas written on it ALT: a picture of a dinosaur with the words yaaaaaaas written on it

That’s cool!

Backyard Proteomics: A Case Study with the Black Widow Spider #JProteomeRes #MassSpec pubs.acs.org/doi/10.1021/...

US20250218758A1 and US20250218757A1

Actual ion mobility? One question - For an orbitrap - is a drift filter good or bad? Will it just saturate (overload/space charge) the OT faster?

Probably behind on this - but it looks pretty cool. New ion routing device - but also looks like a DMA in some land!

It appears the Tenzer lab was well ahead of the curve with this with their platform:
pubs.acs.org/doi/10.1021/...
This was the solution I found to be most useful.

This is what AI Came up with: www.frontiersin.org/journals/nat... and pubmed.ncbi.nlm.nih.gov/32115525/ and www.nature.com/articles/s41...

Very cool approach

Had never heard of quiet posters! Good tip! 🙂

This seems pretty sweet! Thanks for sharing!

I think it is also fair to say - science is generally a big family— what happens to one, is probably felt by all.

That does point to a really interesting experiment though. If one were to break up by funding agency how has posting changed?