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It's here! This week's summary of novel computational and analytical methods for #metabolomics and #lipidomics

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

Sorry for the silence (Government shutdown!) but I'm back with the latest pubs in the #PlacentalCellBio @biomednews.bsky.social

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biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...

Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency. (A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.

Only good papers on mitophagy this week!

biomed.news/bims-tofagi/...

Highlights:
-The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy
-Piecemeal Mitochondrial degradation in plants
-Allophagy?!

Thanks to @biomednews.bsky.social

A molecularly impermeable polymer from two-dimensional polyaramids - Nature Two-dimensional polyaramid polymers are synthesized to form nanofilms that exhibit the lowest gas permeability of any polymer by orders of magnitude, despite lacking crystallinity, enabling molec...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: molecularly impermeable polymer, , soft photoresponsive hydrogel, pollen-inspired biopolymer-based multifunctional films, & more 🧪

This week's (on time) selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social

Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...

Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/

Thanks @biomednews.bsky.social for preselecting!

Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

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Explore the newest issue of the weekly digest on the analytical and computational methods for small molecule analysis:

biomed.news/bims-metlip/...

In collaboration with @biomednews.bsky.social

Vector-stimuli-responsive magnetorheological fibrous materials - Nature Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social

includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪

Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei

It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection

Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/

Thanks @biomednews.bsky.social for preselecting!

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Latest analytical and computational methods for small molecule analysis is here:

biomed.news/bims-metlip/...

Selected for all the researchers in the metabolomics and lipidomics fields in collaboration with Biomed News.

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#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Secretome translation shaped by lysosomes and lunapark-marked ER junctions www.nature.com/articles/s41...

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Here is my weekly selection of #anticancer #therapy and #metabolic #reprogramming! Super interesting papers this issue (including our last study😂🤩😛) Enjoy! 🙏 @biomednews.bsky.social biomed.news/bims-meract/...

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...

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This week's manually curated selection of novel methods for small molecule analysis

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social
#metabolomics #lipidomics

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:

biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"There are years that ask questions and years that answer."-Zora Neale Hurston

What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:

pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima

and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social

Read the full issue here: biomed.news/bims-cebooc/...

#cebooc
@biomednews.bsky.social

#Autophagy and #mTOR papers from last three weeks, enjoy!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

#ER_literature

The weekly Metabolism driving cancer organotropism (biomed.news/bims-metorg/...) and Metabolites-driven PTMs focusing on cancer (biomed.news/bims-prolim/...) at @biomednews.bsky.social are out ☺️

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

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Catch up on the latest research and breakthroughs in metabolomics and lipidomics:

biomed.news/bims-metlip/...
biomed.news/bims-metlip/...

In collaboration with @biomednews.bsky.social

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...

Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...

Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"Inside us there is something that has no name, that something is what we are."-José Saramago

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration www.science.org/doi/10.1126/...