Huge thanks to our collaborators —
Britta Velten (@brittavelten.bsky.social)
, the Klingmüller lab at DKFZ (@klingmuelab.bsky.social), and the Winter team at Thoraxklink Heidelberg
— for their contributions 🙏
We invite you to try out msBayesImpute and welcome any feedback or suggestions! 💬
07.10.2025 08:47 — 👍 2 🔁 0 💬 0 📌 1
msBayesImpute works for both small and large datasets, requires no parameter tuning, and is available in R and Python. A Shiny app will be available soon!
👉 Python version: github.com/Lu-Group-UKH...
👉 R version: github.com/Lu-Group-UKH...
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Across synthetic, semi-synthetic, and experimental serial dilution datasets, msBayesImpute consistently:
✅ Achieved the lowest imputation error
✅ Improved sample-wise normalization
✅ Delivered the highest accuracy in DE analysis across 9 methods
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Missing values in proteomics are often not missing at random (MNAR). Existing methods either assume MAR or oversimplify MNAR.
💡 msBayesImpute learns protein-specific dropout curves directly from the data using Bayesian matrix factorization + probabilistic dropout models.
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🚀 Excited to share our new preprint: msBayesImpute - A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data
👉 Improves imputation accuracy, normalization, and differential expression detection
📝https://www.biorxiv.org/content/10.1101/2025.10.02.679746v1
07.10.2025 08:47 — 👍 15 🔁 2 💬 1 📌 1
Postdoc / Bioinformatician – Computational Multi-Omics for Precision Oncology (m/f/d)
Pflichtfelder sind mit einem (*) markiert.
🚀 Postdoc / Bioinformatician in Computational Multi-Omics for Precision Oncology at Heidelberg University Hospital: karriere.klinikum.uni-heidelberg.de/index.php?ac...
A great short-term opportunity for anyone looking for a bridge position between PhD, postdoc, or the next career step.
01.10.2025 13:24 — 👍 5 🔁 2 💬 0 📌 0
Application - Helmholtz Information & Data Science Academy
We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare!
You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social.
👉 Project: www.helmholtz.de/assets/hidss...
✍️ Apply: hidss4health.de/application
05.08.2025 08:08 — 👍 6 🔁 4 💬 0 📌 0
4. year, 1. Gen PhD student #UniWürzburg in the Warscheid lab. Phospho-/Proteomics, python, mechanical stress, #TeamMassSpec.
Postdoc at Copenhagen University | foundation models for genomics | mtDNA heteroplasmy | ageing & psychiatric diseases | https://biobuild.github.io/
Biophysicist interested in immunology.
Professor at Goethe University Frankfurt | Frankfurt Cancer Institute.
https://agimkeller.github.io
Our group develops and applies computational approaches to study molecular variations and their phenotypic consequence. We are part of DKFZ and EMBL.
Website: https://steglelab.org/
Scientist at DKFZ and EMBL in Heidelberg, loving stats, genomics and genetics. @OliverStegle@genomic.social. For group news see @steglelab.bluesky.social
biology 🧬, microscopes 🔬, and computers 🖥️. Preferably all at once.
Group leader at PTB Braunschweig and professor at TU Braunschweig working in computational proteomics and metabolomics
Computational biologist at the German Cancer Research Center (DKFZ)
Postdoc @Moor lab in the D-BSSE, ETH Zürich.
Working on cancer metastasis, CRISPR, organoids.
PhD student at @farkkilab.bsky.social 🇫🇮
Spatial biology enthusiast 👩🏽💻
Exploring the TME to make a difference🔬✨
Exploring brain cell biology, organelle dynamics & proteostasis.
📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
I study how mutations come about. Based at @columbiauniversity.bsky.social, previously at @normalesup.bsky.social
We study primary #AcuteLeukemia in patient-derived xenograft models in vivo using genetic engineering to identify new treatments and facilitate precision oncology. #TranslationalCancerResearch
website: https://www.helmholtz-munich.de/en/ahs/
PhD candidate at saezlab.bsky.social in computational biomedicine 🔬🧬
Father, husband, scientist. Cell Biology Professor. IMIBIC - UCO
Editor in Chief Endocrine Oncology @endocrineoncology.bsky.social
Biomedical research: hormones & cancer, RNA splicing
Pancreatic Cancer, Neuroendocrine tumors NETs 🦓
Always with a smile 😃
Research Assistant Professor at The Wistar Institute, investigating the metabolic crosstalk between cancer and immune cells | Book & comic lover | Born and raised in Castelló 🍊
Industry scientist,
Mass spectrometry & proteomics enjoyer
Aiming to make the Solar Punk Aesthetic a reality. Science, World Building and Story telling. Researcher/Bioinformatician/Data Scientist.
"Always strive to contribute to others."
Contact:
https://patrickcnmartin.github.io/
Assistant Editor at Cancer Discovery, published by AACR.
BBS Harvard PhD '24 and proud UCLA Bruin.
Views are my own.
Link to sign up for Cancer Discovery News alerts: https://aacrjournals.org/pages/alerts
Max-Eder Research Group Leader & Physician Scientist @NCT @DKFZ @DKTK @Uniklinik_HD
TRYTRAC @CancerCoreEurope
before PostDoc @Uchicago Gajewski lab
#skin #cancer #immunology #spatialbiology #dermatology
