Ramón Piñol

Mars was the Roman god of war.
That’s why we say ‘martial arts,' ‘martial law,' and 'court martial.'

Marshall was the Roman god of designer fashion at discount prices.
That’s why we have Marshall’s.

We are looking for a postdoc fellow to join the group. Focus on studying feeding-relevant slow dynamics in the brain using invivo microscopy approaches. Please share with anyone interested. Thank you. www.training.nih.gov/jobs/pdf-inf...

Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide

@pubs.acs.org Journal of Medicinal Chemistry

pubs.acs.org/doi/10.1021/...

We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW

doi.org/10.1016/j.ce...

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically GLP...

Rigorous dissection of the signaling mechanisms and circuits underlying GLP1R agonist weight loss effects mice. Huge achievement by Claire Gao and team @mikekrashes.bsky.social. Potential avenues for harnessing complexity of signaling to create novel treatments. www.biorxiv.org/content/10.1...

Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus Extreme metabolic adaptations can elucidate genetic programs that govern mammalian metabolism. Here, we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory ...

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus | Science www.science.org/doi/10.1126/...

Congratulations, Ivan!

Huge congratulations to Ivan and the rest of the @mikekrashes.bsky.social lab—formidable job!

Grateful to have contributed a tiny piece to this.

Picture of a naked mole-rat in a fleece bed

🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis

big if true

GABAAR-δ-subunit mediates increased GABAergic inhibition in cardiac DMV neurons after high-fat diet Natural sciences; Biological sciences; Physiology; Neuroscience

New Pub 🚨: Read how we’re tying a specific GABA A receptor subtype to the impact of HFD on central cardiac vagal motor neurons.

www.cell.com/iscience/ful...

This is brilliant!
And not by Charles Dar-wine 😂

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

Headline that says mushrooms may talk to one another with up to 50 words

so they're mycoblogging

Three miles of wiring inside a speck of brain tissue. Here is my story on a milestone in neuroscience. Gift link: nyti.ms/42BWWR7 (Video courtesy Forrest Collman)

For >20 years obesity was thought to be associated with reduced dopamine receptors in brain reward regions. Now, a big study by @vdarcey.bsky.social shows that this may be have been an artifact (top figure panel) due to brain dopamine tone being positively associated with body fat (bottom).

🙌

eredivisiestand:

Cool! I’ll come yes!
I gave a talk at the GWU bio department yesterday

Wassup Carie!

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊

Screenshot of an Al Overview response that reads, “‘On the road’ consists of three words. On, the, and road.”

Tried to google the word count of On the Road.

Jane Fonda on stage at the SAG awards wearing peach sparkly gown with a black worm-like pattern

In addition to her speech on empathy at the SAG awards, Jane Fonda wore a #celegans gown to die for

😂

Alternative explanation: she is making the cases for tildes and always wanted to be Jañe Fonda

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity - Nature Communications Systemic lipid homeostasis requires hepatic autophagy to recycle intracellular fat. Here, the authors identify peripheral mechanisms regulating energy homeostasis, showing that MC3R is a regulator of ...

www.nature.com/articles/s41.... Interesting but report of liver autonomous effects of MC3R a bit surprising given the very low expression of MC3R in liver, at least in humans

Sex-specific effects of appetite suppressants and stereotypy in rats This study investigated the sex-specific effects of commonly prescribed appetite suppressants on body weight and the manifestation of motor side effects, specifically stereotypy. Employing video recor...

New preprint from the lab, here we study head waving stereotypy induced by some appetite suppressants

www.biorxiv.org/content/10.1...

Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation Nucleus accumbens (NAc) dopamine D1 receptor-expressing neurons are known to be critical for processing reward and regulating food intake. However, the role of D2-expressing neurons in this nucleus re...

New paper from the lab!!!
D2-expressing neurons in accumbens is rewarding but paradoxically it stops licking!

journals.plos.org/plosone/arti...

A tweet from Ivan Alcantara with the text: 'I've been preparing for their arrival'. Below this text, there is an image of a child wearing a red sweater standing in front of a door, holding a glowing red trap. Below this image, there is another tweet from Sam Stein with the text: 'Reports are that DOGE staffers are now at NIH'.

I shouldn’t laugh at this but I somehow needed to.