Alessio Yang

Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus Abstract. Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historical

Thrilled to share that my first paper in the lab of @drmichaelway.bsky.social is now published in @narjournal.bsky.social!

We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼

doi.org/10.1093/nar/...

26.06.2025 18:48 — 👍 7    🔁 4    💬 0    📌 0

Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.

26.06.2025 02:24 — 👍 11    🔁 2    💬 0    📌 0

Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology

23.06.2025 19:23 — 👍 55    🔁 17    💬 1    📌 5

Happy to see it out!
Very cool work I was able to contribute in. If you are interested in how we can use AlphaDesign to make de novo inhibitors of phage defence systems check the paper out!

19.06.2025 16:43 — 👍 8    🔁 1    💬 0    📌 0

Elucidating the mechanisms of action and evolutionary history of phage anti-defence proteins Phages and bacteria are locked in a molecular arms race, with phage anti-defence proteins (ADPs) enabling them to evade bacterial immune systems. To streamline access to information on ADPs, we develo...

Very excited to share our preprint on a new resource: the Encyclopaedia of Viral Anti-Defence Systems (EVADES)! This is the main result of my PhD at ‪EMBL-EBI (@ebi.embl.org)‬
and the University of Cambridge (@cam.ac.uk‬)! 🔗 www.biorxiv.org/content/10.1... 🧵1/n"

08.06.2025 11:08 — 👍 56    🔁 26    💬 1    📌 0

Sketch of membrane-enclosed compartment with particles on its surface, which interact with an adjacent structure

🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv:

Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739)

Where we explore how the physical properties of living systems can help cells process spatial information.

18.06.2025 17:07 — 👍 43    🔁 16    💬 1    📌 4

Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. Currently known phage counter-defense systems are specific to (the activity of) ...

Excited to share our preprint with @savitski_lab led by @tarabartolec.bsky.social, @KMitosch & Clément Potel! We uncovered a mechanism by which the T7 phage broadly counteracts DNA-targeting bacterial defenses by deploying a loose cannon kinase in its genome @embl.org www.biorxiv.org/content/10.1...

23.12.2024 07:29 — 👍 69    🔁 29    💬 1    📌 1

1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...

23.12.2024 07:29 — 👍 37    🔁 16    💬 1    📌 2