Rimas Orentas

Leroy Hood holds forth on the future of genomics and phenomics. Just as we only now have incorporated epigenomics into human biology- there is likely still missing major data sets to allow new advances to come. i e. one proteins can be modified 400 different ways. @systemsbiology.bsky.social

The CAR-T therapy team at Taichung medical center in Taiwan - amazing world class work. This includes new CARs from #Miltenyi, Novartis Tcharge for autoimmune disease and a robust regenerative medicine program

#UNGA80 #ECSA East, Central, Southern Africa Session at the UN General Assembly Mtg #ScienceDiplomacy chair Prof Ntobeko Ntusi looking to bridge divides through shared knowledge and establishing regional centers of excellence. We are here to advocate for global health for the UN Pact for the Future

Yes we do like you

Having visited private and public institutes (view is the medical school at Albert Einstein SOM in São Paulo)- I am inspired by the new approaches for cell and gene therapy. Most of the world has looked at what our “market” has produced and is creating affordable alternatives

No one, at this point, is stupid and venal enough to take the administration up on this - right?

Solid tumors- how do we get a patient specific TME diagnosis and data-driven intervention. In people.

Dr Hanahan wins the Pezcoller! #AACR25 @theaacr.bsky.social and published today the IL-1 signature of tumors induces systemic immunosuppression_ and is reversed by anti- IL-RAP antibody.

Wonderful overview today by Ken Anderson @theaacr.bsky.social #AACR25 of the advances in MM- adding CARs to degraders (imids) and blockers (bortezomib) both of which also have immune activity has completely changed the outlook for patients- and that’s why we are here

RFK Jr. forces out Peter Marks, FDA’s top vaccine scientist Marks, an architect of Operation Warp Speed for coronavirus vaccines, warned that a measles outbreak shows how confidence in science is being “undermined.”

We owe him much for his leadership at CBER during a period of remarkable therapeutic advances. The havoc caused by this administration will have a devastating impact for years.

www.washingtonpost.com/politics/202...

At 9 yrs old, my granddaughter was diagnosed with DIPG. It is terminal, usually within 9 months. Because of Dr. Vitanza at Seattle Children’s and clinical trials, we had her mostly symptom free for about 32 months. Make these cuts make sense! I am outraged!

Engaging talk by Jen Adair @fredhutch.bsky.social Tandem2025 @astct.bsky.social on efforts to make cell and gene therapy available in low and middle income countries. Academic centers need to step up. Great to see my friend @cgtgaithersburg.bsky.social in the Global Gene Therapy Initiative

Dr S Davies from cincinnatichildren’s presents a challenge-using a new vector system and reduced intensity conditioning to keep #sicklecell therapy low cost by keeping the process in academic medical centers & not a strictly high-priced pharma product @ascaa.bsky.social @astct.bsky.social #Tandem25

Dr M Bleakly from @fredhutch.bsky.social delivering a master class on using minor antigens to create anti-leukemia T cells in the context of HSCT @astct.bsky.social #Tandem25 incredible analysis of hematologic restricted targets

Dr N Shah from MCW presenting Tandem CD20-19 CAR-T using fresh in/fresh out manufacturing allowing many patients to receive this therapy who otherwise would not qualify @astct.bsky.social #Tandem25

Defend the NIH - TimmermanReport.com Too many people don’t believe anymore in the American Dream. But if you can’t dream big, you can’t accomplish big things. Today, the National Institutes of Health — biomedical science itself — is unde...

Defend the NIH. timmermanreport.com/2025/02/defe...

Stand Up for Science rallies will be held in DC and state capitals on March 7th. Share with friends. Sign-up here to get email updates with details: www.eventbrite.com/e/stand-up-f...

Michael Holmes presents wall shaking data showing in vivo gene therapy using #Tessera gene writers to cure sickle cell disease and create CARs directly in vivo in model systems #Tandem25

Andy Sharenberg #UmojaBio presents the direct in vivo platform to create CAR-T #Tandem2025

@lulii4.bsky.social love the 4

So-when is the March for Science? I only see references to the previous one. We can’t let NIH be run by political appointees. This is proposed at the institute level and will likely go much further. The war on DEI, the intimidation of our colleagues who are visa holders…we know why we should march

Trump's NIH Freeze Puts Scientific Research at Risk America’s best scientific minds are scrambling to determine the impact of the disruption.

Some thoughts on the confusion and anxiety created by the current freeze on communications, hiring, grant reviews, travel, etc at NIH (gift link):

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Damn. Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring. All study sections are halted. www.science.org/content/arti...

Our federal colleagues’ (NIH) communications are being actively monitored by the government. They have been told to inform on one another if there is any DEI activity. If you are a fed- go get a personal device now. You should have been using your own already.

The Evolution of Treatment-Free Remission One of the most remarkable achievements of the TKI era has been the capacity to induce deep molecular remissions that are sustainable off therapy in chroni

Treatment-free remission in CML offers hope for sustainable recovery, aiming to make it a common pathway towards potential cures.

by Hughes TP, Yong AS and Ross DM in Blood #MedSky

📖 read the article:

Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial - Nature Medicine In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusion...

www.nature.com/articles/s41.... The new Brainchild publication for B7H3 CAR-T cell therapy for pediatric brain tumors. Surprising and encouraging that CNS tumors may be the next breakthrough in the field #seattlechildrens #UWpediatrics #DIPG #CARTcell #BTCCCR #immunotherapy

Pediatric cancer community "devastated" as funds removed from spending bill Nancy Goodman, founder and CEO of Kids v Cancer, told Newsweek the funding would go to critical research for pediatric cancer.

Nancy Goodman, founder and CEO of Kids v Cancer, told Newsweek the funding would go to critical research for pediatric cancer.

The durability of cure for ADA-SCID with lentiviral vectors is amazing. Rarity, a public benefit corp., has been formed to carry this therapy forward where previous models have failed #ASH24 Dr M Masiuk presented the plot below-one of many showing the durability of correction #kohnlab #rarity #CIRM

Dr I Odame sharing a vision to make high impact changes on sickle cell disease care in Africa that will scale #ASH24 Hydroxyurea access must be the cornerstone #CONSA #sicklecell