Marcel Werner

Great work from @ioannistsirkas.bsky.social and the @hamperllab.bsky.social!

Great overview on some of the recent work from my PhD lab! @hamperllab.bsky.social

If it is related to thesis submission just let me know. I still have all the information and forms saved.

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Thank you so much! 🤩

Delighted to share that I am joining @grothlab.bsky.social and @groth-anja.bsky.social at Danish Cancer Institute for my postdoc. 🇩🇰

I am looking forward to working on advancing our understanding of epigenome replication and maintenance. 🧬🧫

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

🌟 SAVE THE DATE: Talent Forum 2025!

🗓️ November 18–19
📍 @www.helmholtz-munich.de‬, Germany

Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!

Apply by July 31 for a speaker spot —travel & accommodation covered.

🔜 Website coming soon!

Goodbye @hamperllab.bsky.social and thank you for incredible 4.5 years! It has been a pleasure to work with all of you and I will miss you a lot. Thank you also to @epihmgu.bsky.social and the Munich chromatin community. I could not have picked a better place to do my PhD!

To new adventures! 🇩🇰

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.

🚨Paper Alert!

👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!

🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.

A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
 
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

Thanks a lot, Alva! See you in May!

Thanks a lot, Julio!

Thank you so much, Anja! I'm super excited to join the lab in May! 🤩

Thanks a lot! 😊

Big thanks to everyone involved in this great team effort in the @hamperllab.bsky.social and colleagues at @epihmgu.bsky.social @www.helmholtz-munich.de. Also thanks to @narjournal.bsky.social for a smooth review process that significantly improved our work.

Finally, we show that H3K79me2/3 is actively deposited at TRC sites by DOT1L and that DOT1L activity is required for transcriptional recovery and prevention of DNA damage. (6/n)

Intrigued by our findings on nucleosome dynamics, we screened several histone modifications for an association with TRCs. Strikingly, we discover H3K79me2/3 as a TRC-associated histone modification. (5/n)

Focusing on chromatin, we show that TRC induction stabilizes R-loops, which causes a drastic reduction of local nucleosome occupancy, suggesting that R-loops are incompatible with nucleosome formation. (4/n)

Further, a precise analysis of DNA replication revealed that R-loop mediated TRCs slow or block DNA replication fork progression in a highly localized manner. (3/n)

To better answer this question, we first built a new reporter system based on genomic integration of the R-loop forming mAIRN sequence. We show that your system can efficiently induce TRCs, R-loops, and DNA damage. (2/n)

Transcription and replication are fundamental nuclear processes that require extensive chromatin remodeling to perform their function on the genome. What happens to chromatin if these two huge complexes collide in the genome? (1/n)