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@stapleslab.bsky.social

118 Followers  |  225 Following  |  9 Posts  |  Joined: 18.02.2025  |  1.4158

Latest posts by stapleslab.bsky.social on Bluesky

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Postdoctoral Fellow - Costa Lab Salary for this Role: From Β£45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

21.07.2025 14:57 β€” πŸ‘ 25    πŸ” 31    πŸ’¬ 0    πŸ“Œ 0

Done lefkas, parga, Crete and Athens riviera a few times. All pretty fab. Corfu definitely on the list...

20.04.2025 10:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Was looking at Malta, but have gone for Xmas in Iceland - but different:)

20.04.2025 10:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Pre-print alert! Together with @stapleslab.bsky.social and @cejkalab.bsky.social we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. πŸ‘‡πŸ‘‡

10.04.2025 07:23 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1

"give mouse guts now pls"

09.04.2025 20:16 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Cheers Pietro

09.04.2025 19:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
IFI16 senses and protects stalled replication forks Replication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social

www.biorxiv.org/content/10.1...

09.04.2025 16:08 β€” πŸ‘ 12    πŸ” 3    πŸ’¬ 2    πŸ“Œ 1
Post image

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

25.03.2025 16:00 β€” πŸ‘ 66    πŸ” 25    πŸ’¬ 2    πŸ“Œ 2

Nice work - our data in a totally different model suggests the same

24.03.2025 18:31 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Pls repost. Postdoc role on post-replicative ssDNA gap processing. Interesting models that should float replication aficionados boats. DM or c.staples@bangor.ac.uk for info. Until Dec26 but will strive for funding to provide continuity.
Fantastic place to live+work
www.jobs.ac.uk/job/DMG682/r...

24.03.2025 18:28 β€” πŸ‘ 0    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
Job Details | Bangor University Jobs

jobs.bangor.ac.uk/details.php....

12.03.2025 14:51 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info

12.03.2025 14:51 β€” πŸ‘ 7    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0

@stapleslab is following 20 prominent accounts