@bengoult.bsky.social
Talin as a memory molecule #MeshCODE. Talin shock absorbing materials #TSAM. Professor of Mechanistic Cell Biology at University of Liverpool Dad, Husband. Hobbies: Mechanobiology, talin, looking at the sky
Incredibly bright 🌈
16.02.2026 13:45 — 👍 1 🔁 0 💬 0 📌 0Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...
08.02.2026 14:45 — 👍 11 🔁 5 💬 0 📌 1My personal obituary for Richard Hynes now live on the Manchester Cell-Matrix Centre website. www.manchester-matrix.org/news/profess...
30.01.2026 16:45 — 👍 11 🔁 5 💬 2 📌 0Last night @museeorsay.bsky.social we saw fluorescence images of cells or protein filaments seemingly grow along the internal structures of the ceiling of the main hallway. It was mesmerising I loved it Science is Art! More of this please! Congratulations @manuelthery.bsky.social very cool 🤩🤓
25.01.2026 10:43 — 👍 23 🔁 4 💬 0 📌 1
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
It provides a summary of our ongoing research to understand the binary switches built into the synaptic scaffold protein talin, and how these switch patterns change when synapses are stimulated.
20.01.2026 21:10 — 👍 1 🔁 1 💬 0 📌 0
Check out our new Talin Infographic!
The poster summarises why we think there is a binary code in animals.
Great artwork made by Josh Hawley @golgigraphics.bsky.social
Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
When R11 unfolds it exposes a cryptic Aggregation Prone Region, which we call APR1. This motif mediates talin-talin oligomerisation. Excitingly vinculin binding resolves these talin oligomers revealing that vinculin acts as a mechano-chaperone to maintain mechanotransduction through talin.
14.01.2026 18:38 — 👍 0 🔁 0 💬 0 📌 0Great collaboration with Vesa Hytonen and Jie Yan's teams and led by Neil Ball in my lab @liverpooluni.bsky.social
14.01.2026 18:38 — 👍 0 🔁 0 💬 1 📌 0Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin.
IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11.
We also show a new role for vinculin as a mechano-chaperone
Coming 2027...
08.01.2026 13:38 — 👍 4 🔁 2 💬 0 📌 0
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!
Reach out if you are interested 👍
Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
"
www.biorxiv.org/content/10.6...
Work driven by @anagracanin.bsky.social
A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social
🎉
06.12.2025 09:27 — 👍 3 🔁 0 💬 0 📌 0Gutted I missed this. Glad it went well.
05.12.2025 18:03 — 👍 0 🔁 0 💬 0 📌 0
This title has "very lethal" energy
03.12.2025 19:20 — 👍 1 🔁 0 💬 1 📌 0Congratulations, @samstehbens.bsky.social & Co !!! 🥳🥳🥳👏👏👏
www.nature.com/articles/s41...
spicy!
genesdev.cshlp.org/content/33/2...
🧵
29.11.2025 13:44 — 👍 1 🔁 2 💬 0 📌 0
Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...
24.11.2025 16:49 — 👍 8 🔁 6 💬 0 📌 0@livuni-ismib.bsky.social and @lincneurosci.bsky.social
11.11.2025 10:32 — 👍 1 🔁 0 💬 0 📌 0
11.11.2025 10:29 — 👍 0 🔁 0 💬 1 📌 0
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Both ridiculous.
01.11.2025 16:53 — 👍 0 🔁 0 💬 0 📌 0That’s a great idea for next time. Here i found a bed seat and had a nap.
01.11.2025 12:27 — 👍 1 🔁 0 💬 0 📌 0
