Yi Feng

Our EMBO workshop is now live. Visit us in Bath this summer for a two week workshop designed to help you study host-microbe interactions in the zebrafish, and develop the bioinformatics skills needed to analyse the complex data sets that arise from microbiomic studies.

Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas Dual host-pathogen transcriptional profiling defines granuloma-specific programs during mycobacterial infection.

Excited to share work led by the wonderful Gopi Viswanathan examining roles of granuloma neutrophils &defining bacterial transcriptional profiles within mycobacterial granulomas. Cool collab with Qingyun Liu at UNC for evolutionary analysis of granuloma-specific genes www.science.org/doi/10.1126/...

Wow! 🤩 this is amazing! What will be the master controllers for these structural dynamics?

With @burgesslab.bsky.social, not one, but TWO freshly caught T2T zebrafish reference genomes for the Tübingen and AB strains 🎣 🎣 🎉

A. Schematic of imaging experiment, with drawings of zebrafish larvae at 3dpf and 7dpf underneath a timeline of imaging every 8 hours. B. (Top) Heatmap of Erk activity at single cell resolution; (Bottom) Raw images of Erk-KTR-mCerulean signal. Scale bar: 100 μm.

#DBfeature 🐠

A new powerful live imaging platform tracks Erk signalling dynamics in developing zebrafish hepatocytes at single-cell resolution.

By Faraz Ahmed Butt, Alessandro De Simone, Stefano Di Talia, Kenneth Poss

tinyurl.com/ve5vzp6c

For those interested, we’ve got two #WomenInScience lists, a list of resource and society accounts that support #zebrafish and lists of Senior Scientists & Group Leaders that work with our favorite fish. If you’re not on a list and want to be added (or just want to double-check), please reach out! 🧪

Edinburgh castle glowing in moonlight framed by trees

Moonlit view of old buildings above Princes Sr gardens

However long I live here I will never get used to how utterly beautiful the views from Princes St are. This was last night 😍

Inject some #zebrafish into your timeline with our updated Starter Packs! 🧪

WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
"" v3: go.bsky.app/JvjuSZg
"" v4: go.bsky.app/2c4WLQK

Rumoured photo from the first international workshop on zebrafish at the university of oregon. Image credit to Cecilia Moens. How many people can you spot?

The first international workshop that focused on #zebrafish was convened in 1990 in Eugene, Oregon. Sponsored by NIH and NSF, the gathering of ∼40 scientists sought to evaluate the research potential of the tiny fish. Today, nearly 1,800+ zebrafish labs exist worldwide. #ZebrafishFunFacts 🧪

Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+...

Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...

The @fengfishlab.bsky.social lab have found that mutation in the Ras gene can change normal cells and trigger an immune response that promotes cancer formation - all within 24 hours. This may offer new ways to detect or prevent cancer before it becomes established.

edin.ac/47h6bZq

Hand crafted birthday card and presents

Wondered what my daughter was up to during half-term? She presented these carefully crafted B-day gifts to me this morning! 😊😊

Chinese national interested in a PhD using fish?

Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol

Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...

Please circulate widely!

Anyone still using these? We should be able to do an update, if there’s interest. #zebrafish

Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!

Zebrafish embryo undergoing gastrulation. Credit to Dr. Gopi Shah at EMBL. #ZebrafishZunday 🧪

Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!

Poster of the 100-year history of The Company of Biologists.

1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

abstract painting with birdlike creatures on a blue ground

Twittering Machine, Paul Klee, 1922, gouache, ink and watercolor on paper

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Pathway to Independence: a forecast for the future of developmental biology ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows

Read about the scientific visions of eight dev bio post-docs entering the academic job market

journals.biologists.com/dev/article/...

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Transitions in development – an interview with Jeffrey Farrell

@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.

journals.biologists.com/dev/article/...

Hey friends - Daniocell is experiencing a temporary outage right now. The NICHD server it is hosted on got dropped from the NIH’s firewall list & so currently can’t be accessed outside the NIH. The relevant IT teams are working to resolve it. Sorry for any inconvenience. It’ll be back soon!!

DANIO-CODE DCC This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.

#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net

CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...