Yi Feng

Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+...

Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...

The @fengfishlab.bsky.social lab have found that mutation in the Ras gene can change normal cells and trigger an immune response that promotes cancer formation - all within 24 hours. This may offer new ways to detect or prevent cancer before it becomes established.

edin.ac/47h6bZq

Hand crafted birthday card and presents

Wondered what my daughter was up to during half-term? She presented these carefully crafted B-day gifts to me this morning! 😊😊

Chinese national interested in a PhD using fish?

Fully-funded scholarships @bristolbiosci.bsky.social from the China Scholarship Council-University of Bristol

Success rates are high, check out the details here and get in touch:
www.bristol.ac.uk/students/sup...

Please circulate widely!

Anyone still using these? We should be able to do an update, if there’s interest. #zebrafish

Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!

Zebrafish embryo undergoing gastrulation. Credit to Dr. Gopi Shah at EMBL. #ZebrafishZunday 🧪

Today we are honoured to host Dr Sally Lowell @cellysally.bsky.social (University of Edinburgh), winner of the 2024 BSDB Wolpert Medal, who is giving a talk in our DRN external seminar series
@bsdb.bsky.social
Host: Marysia Placzek
All welcome!

Poster of the 100-year history of The Company of Biologists.

1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

abstract painting with birdlike creatures on a blue ground

Twittering Machine, Paul Klee, 1922, gouache, ink and watercolor on paper

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Pathway to Independence: a forecast for the future of developmental biology ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows

Read about the scientific visions of eight dev bio post-docs entering the academic job market

journals.biologists.com/dev/article/...

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Transitions in development – an interview with Jeffrey Farrell

@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.

journals.biologists.com/dev/article/...

Hey friends - Daniocell is experiencing a temporary outage right now. The NICHD server it is hosted on got dropped from the NIH’s firewall list & so currently can’t be accessed outside the NIH. The relevant IT teams are working to resolve it. Sorry for any inconvenience. It’ll be back soon!!

DANIO-CODE DCC This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.

#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net

CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪

This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

New study online today! We present a method to identify insertion sites of Tol2 transgenes in zebrafish #zebrafish #Tol2 #Transgene www.cell.com/cell-reports...

ZDM18 Abstract Submission — ZDMS

Abstract deadline for #ZDM18 in Boston ends tonight (EST) for those to be considered for oral talks. More details here: www.zdmsociety.org/zdm18-abstra... #ZebrafishMeeting

Now online in Cancer Discovery: Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA - by Yuxuan Wang, Nickolas Papadopoulos, Elizabeth Platz, Bert Vogelstein, and colleagues doi.org/10.1158/2159...

This happens tomorrow, still time to register, free webinar, cutting edge zebrafish cancer model stories! Come join us!

There’s now a MedakaBase paper that you can cite, courtesy of @kurakulabmsm.bsky.social 🐠

🔗 to MedakaBase: medakabase.nbrp.jp

Check out the latest microscopy preprints including our recent favorite tool (LUCID) from #WeinsteinLab 🔥

🔗 to preprint: www.biorxiv.org/content/10.1...