Bina Singh

Our paper is finally out!
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology

Emerging roles of lipids in the flavivirus life cycle Flaviviruses, such as Dengue, Zika, and West Nile virus, cause a significant global health burden and have earned attention as high-pandemic risk pathogens. Flaviviruses interact closely with cell mem...

Emerging roles of lipids in the flavivirus life cycle www.cell.com/trends/micro...

🎄✨ Season’s Greetings from PDBe ✨🎄
The PDBe wishes you a very Merry Christmas and a Happy New Year. We are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, and we look forward to seeing you in the New Year.

Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...

While the FIB mills, I doodle…. #MicroscopyHumor #FIBLife #AutoTEM #CryoEM

Delighted to see our work in press! 🙌🔬🧠

Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions.

Excited to see where in tissue structural cell biology goes next 👀!

#liftlaughlove #teamtomo #whopper

A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis - Nature Communications There are no vaccines or antivirals available against enterovirus D68. Here, the authors report Jun6504 as a 2C inhibitor and show that it provides broad-spectrum antiviral activity against EV-D68, EV...

"A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis"

www.nature.com/articles/s41...

structure prediction is not science if not experimentally validated. period

Cryogenic Electron Tomography Redefines Herpesvirus Capsid Assembly Intermediates Inside the Cell Nucleus. www.biorxiv.org/content/10.1101/2025.06.27.661840v1 #cryoEM

Just what happens when cryo conditions get too creative: ice contamination feels like sculpture. #CryoFIB #CryoEM #ElectronMicroscopy #MicroscopyArt #MicroscopyMonday

Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET - Nature Communications This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-e...

"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"

www.nature.com/articles/s41...

From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report…

My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social

Please check it out 😊

www.sciencedirect.com/science/arti...