Jooho Lee

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic M...

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...

Fun writing this piece with @bartegiani.bsky.social!

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection - Molecular Cancer Glioblastoma (GBM) is the most aggressive and common type of primary malignant brain cancer in adults. GBM often recurs locally near the resection cavity (RC) following the surgical removal of primary...

Thank you for reviewing my previous paper. I enjoyed reading your insights. I’ve also written a follow-up paper, and I hope you might find it interesting:
molecular-cancer.biomedcentral.com/articles/10....

Estimating de novo mutation rate over four generations from total 28 individuals. 👏

postdoc opportunity - join our team! · Verhaak Lab The Verhaak lab in the Department of Neurosurgery at the Yale School of Medicine is looking to recruit a postdoctoral associate who will help us develop new therapeutic approaches to treat patients wi...

We are looking to recruit new postdocs! Please check verhaaklab.com/archive/2025....

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection - Molecular Cancer Glioblastoma (GBM) is the most aggressive and common type of primary malignant brain cancer in adults. GBM often recurs locally near the resection cavity (RC) following the surgical removal of primary...

Excited to share our latest paper in Molecular Cancer! We reveal how recurrent glioblastomas originate from distant ventricular regions and identify potential therapeutic targets. Check it out! 🔬🧠
🔗 molecular-cancer.biomedcentral.com/articles/10....

Clinical applications of human organoids - Nature Medicine Organoid research is moving beyond developmental and disease biology, driving insights into current and emerging health threats and enabling personalized and regenerative medicine applications.

A Review in Nature Medicine examines how organoid research is moving beyond developmental and disease biology, driving insights into current and emerging health threats and enabling personalized and regenerative medicine applications. 🔒

📣 Open computational PhD & Postdoc positions!

Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus

📢 Please RT (what's the bsky equivalent here?) and distribute !

👇A quick instruction on how to apply

Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...

Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...

Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...

Cancer #aneuploidy observed in ~normal breast tissue from healthy women. 👏 from Lin & Wang, Navin Lab www.nature.com/articles/s41...

Related: Context is everything in the eyes of #evolution. www.nature.com/articles/s41...

Congrats to Postdoc Xue Li in our lab for the Young Investor Award! She will present our work "DISTANT ORIGIN OF GLIOBLASTOMA RECURRENCE: NEURAL STEM CELLS SERVE AS A SOURCE OF TUMOR RECONSTRUCTION AFTER RESECTION” this morning at 830AM in General Assembly A #SNO2024