Geming Lu

Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...

Improving cellular fitness of human stem cell-derived islets under hypoxia.
www.nature.com/articles/s41...

Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses Pregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a...

Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity.
www.science.org/doi/10.1126/...

Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation - Nature Communications Xenotransplantation is a promising option when allogeneic donors are unavailable but hampered by a more stringent immunological barrier. Here authors show that hypoimmune cells engineered to overcome ...

Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
www.nature.com/articles/s41...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms.
www.cell.com/cell-genomic...

Distinct adipose progenitor cells emerging with age drive active adipogenesis Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat un...

Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/...

#SkeletalMuscle #Mitophagy #ERPhagy

ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy

@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation The sequential order of NGN3 and NEUROD1 expression shapes their pioneer functions in pancreatic endocrine differentiation.

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation The sequential order of NGN3 and NEUROD1 expression shapes their pioneer functions in pancreatic endocrine differentiation.

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...

Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells

Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes - Nature Communications The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA...

Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes.
www.nature.com/articles/s41...

Characterization of islet cells from people with type 1 #diabetes underscores the complex interplay between immune signaling, metabolic stress, and cellular identity in shaping islet cell phenotypes in #T1D @bcellorg.bsky.social www.biorxiv.org/content/10.1... @albertadiabetes.bsky.social

Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants Arthur and Nguyen et al. leverage iPSCORE, a large collection of three early developmental-like tissues with corresponding molecular datasets (RNA-seq, ATAC-seq, H3K27ac ChIP-seq), to map over 70,000 ...

Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants.
www.cell.com/cell-genomic...

High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response - Diabetologia Aims/hypothesis Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular respo...

High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of #diabetic #kidney disease by inhibiting the Th1 response tinyurl.com/nhhj48sx 🔓

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...

Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...

β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.

β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine www.science.org/doi/10.1126/...

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy Activation of innate immune signaling occurs during the progression of immunometabolic diseases, including type 2 diabetes (T2D), yet the impact of innate immune signaling on glucose homeostasis is co...

🚨 Excited to share new results! We find that beta cells activate innate immune signaling to adapt to obesity or metabolic stress by promoting both Parkin dependent and independent mitophagy.

Mitophagy FTW! We'd be honored if you gave it a read. 😀
www.biorxiv.org/content/10.1...

RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs Small nucleolar RNAs (snoRNAs) are a class of non-coding RNA molecules whose precursor transcripts are capped and polyadenylated. However, these end modifications are detrimental to snoRNA function an...

#RNaseIII #snoRNA #Spombe

www.biorxiv.org/content/10.1...

MDA5 variants trade antiviral activity for protection from autoimmune disease Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studie...

MDA5 variants trade antiviral activity for protection from autoimmune disease.
www.medrxiv.org/content/10.1....

Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Mechanistic insights and approaches for beta cell regeneration.
www.nature.com/articles/s41...

The Center for Epigenomics at UC San Diego is pleased to announce Spatial Epigenomics Virtual Day, which will take place on Jan. 29, 2025, on Zoom. This event will feature multiple talks about Spatial Epigenomics from leading experts in the field. Registration is now open: bit.ly/41PJ3Pc

ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION Biological sex differences in morbidity upon influenza A virus (IAV) infection are linked to stronger IFN-centered immune responses in females, yet the regulatory role of sex hormone receptors in immu...

ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION.
www.biorxiv.org/content/10.1...

Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats Numerous studies highlight the essential role of type I interferon (IFN) responses in type 1 diabetes. The absence of type I IFN signaling is associat…

Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats.
www.sciencedirect.com/science/arti...

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions o...

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis.
www.science.org/doi/10.1126/...

Antigen-specific immunotherapies for autoimmune disease - Nature Reviews Rheumatology In this Review the author summarizes the current approaches for antigen-specific therapies in the treatment of autoimmune disease and highlights the challenges that need to be addressed for successful...

Antigen-specific immunotherapies for autoimmune disease.
www.nature.com/articles/s41...

Sex‐specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors Our study underscores the critical role of sex as a significant variable in T1D patients and T1D progressors, with discernible differences in cytokine levels observed only when stratified by sex. Det...

Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors.
faseb.onlinelibrary.wiley.com/doi/full/10....

Apology for the non-working link to this intriguing Spatial Skin paper.

Spatiotemporal single-cell roadmap of human skin wound healing

Here is the correct link

www.cell.com/cell-stem-ce...

A famsin-glucagon axis mediates glucose homeostasis Glucagon is essential for glucose homeostasis during fasting and in diabetes, yet the mechanisms regulating its secretion are not fully understood. Long et al. demonstrate that famsin, a gut-secreted hormone, stimulates glucagon secretion through calcium mobilization, thereby promoting hepatic glucose production to maintain glucose homeostasis during fasting and in diabetes.

A famsin-glucagon axis mediates glucose homeostasis.
www.cell.com/cell-metabol...

The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes In autoimmune Type 1 diabetes (T1D), immune cells infiltrate and destroy the islets of Langerhans, islands of endocrine tissue dispersed throughout the pancreas. However, the contribution of cellular ...

The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes.
www.medrxiv.org/content/10.1...