Chao Qi

The best cover🥰, paired cats & paired helical filaments.

17.07.2025 18:47 — 👍 33    🔁 4    💬 0    📌 2

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W - Nature Structural & Molecular Biology Qi et al. used cryo-electron microscopy to determine the structures of tau filaments from the brains of individuals with MAPT mutants V337M and R406W, known to give rise to frontotemporal dementias. T...

Finally, the paper by @qcxy8886.bsky.social on #cryoEM of tau mutants V337M and R406W is out in NSMB (which is not the fastest journal). Tau filaments with these mutations have the same structures as in AD, which may be useful for the development of faster models.

www.nature.com/articles/s41...

16.07.2025 06:33 — 👍 18    🔁 3    💬 0    📌 0

At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.

10.04.2025 17:22 — 👍 15    🔁 3    💬 0    📌 0

“If you’re really curious about science, then you should do it.”

We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes.

youtu.be/qaudt961iMU

03.04.2025 14:42 — 👍 10    🔁 3    💬 0    📌 0

I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?

01.04.2025 19:44 — 👍 12    🔁 2    💬 3    📌 0

Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies | ALZFORUM

Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳
www.alzforum.org/news/researc...

28.03.2025 14:12 — 👍 6    🔁 1    💬 0    📌 0

Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold Nature Structural & Molecular Biology - Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain....

Happy to share our latest publication on
@naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W.
thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳
rdcu.be/edqzW
rdcu.be/edoGv

13.03.2025 13:50 — 👍 19    🔁 5    💬 1    📌 1

Cool, Congratulations! 🥳

17.01.2025 00:11 — 👍 1    🔁 0    💬 0    📌 0