George Ghanim

cryo-em doughnut

In the neighborhood of 2Å. Sometimes I find a few in the better parts of a 2.3Å map.

Calling all structural biologists in the NYC metro area! The nysbdg.bsky.social is back for yet another gathering for 2025!

Register here 👉🏼 buff.ly/N42ul1b

I look forward to seeing you there! 😎

#structuralbiology #cyrstallography #cryoEM #NMR
#chromatography #proteinpurification #AKTAsystems

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

My first impression is that the heterogeneity isn't going to be the biggest challenge. I'm already pulling my hair over symmetry and anisotropy. 🙃

#CAHRA2025 #CompHet #CryoEM

Pretty excited about this "2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms" #CAHRA2025
https://heterogeneity.notion.site/challenge

I started looking at the compositional heterogeneity challenge (#CompHet), some very weird things in there. Curious to figure out […]

CAHRA 2025: Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms A community-wide data processing challenge for cryo-electron microscopy.

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem

#CryoEM how do we feel about this instrument? We may be in the market and I want to know what people are currently using.

I did. It lived in my 1M NaOH stock.

Hummm

This is an auto include on my reading list because I know its going to be good. Congrats @vcushing.bsky.social @bjgreber.bsky.social and all!

Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.

When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

Juan B. Rodriguez Molina

Congrats to #LMBAlumni Juan B. Rodriguez Molina, former Investigator Scientist in the LMB's Structural Studies Division, newly appointed Assistant Professor in the Dept of Molecular and Cellular Biosciences at the University of Cincinnati College of Medicine
researchdirectory.uc.edu/p/1818215

Looks good! Looking forward to the preprint because i’m keen on how you did this.

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

Hey thats me.

Since when are vaults cool again? Loving it

My lab has developed mSHINE, allowing for both highly multiplexed and portable nucleic acid detection. Very exciting work led by the talented @sijbren-kramer.bsky.social, who is off to do a PhD at Stanford at the end of the month!

Now out in Science Advances: www.science.org/doi/10.1126/...

😍😍😍

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Attendees of the recent bacteriorhopsin symposium, photographed from above.

Balsawood model of bacteriorhodopsin

Black and white photograph of Nigel Unwin and Richard Henderson sitting outside the LMB, 1991

Symposium attendees applauding in the LMB's Max Perutz Lecture Theatre.

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.

Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...

#LMBNews 🧪🔬

Jonathan St. Ange Receives Fulbright U.S. Student Award for 2025-2026 Jonathan St. Ange, a Ph.D. Student in Molecular Biology at Princeton University, has received a Fulbright U.S. Student Program award to conduct research in Molecular Biology in France for the 2025-202...

I somehow missed this piece about Jon in my lab: molbio.princeton.edu/news/2025/jo...

Yes! ... but what's a semi-autoloader?

I just got it. This is great.

Aedes albopictus (asian tiger mosquito)

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics

At Darwin College: Richard Henderson Jacqueline Milne Sriram Subramanian Nigel Unwin David Barford Da-neng Wang John Rubinstein

John ring's the LMB seminar bell to call the audience back in after a coffee break.

Returned from a wonderful symposium in honour of the 50th anniversary of Richard Henderson's and Nigel Unwin's 1975 paper on the structure of bacteriorhodopsin - the paper that started the field of membrane protein structural biology.
Also fulfilled my dream of ringing the LMB seminar bell.

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

Hurray! 🥳🎉🥂

I wish I could bookmark this thread 1) as a reference and 2) to look at every now and again.