Hyman Lab

puzzle pieces are connected to represent CD-CODE database concept. landscape orientation (4 puzzle pieces top row, 5 puzzle pieces lower row). Top row: puzzles representing applicability, API, infectious condensate with logo representing pathogen cell and condensate, condensatopathies with a stethoscope logo, text: CD-CODE CrowDSourcing Condensate Database and Encyclopedia. Bottom tow: puzzles representing community, CD-CODE logo, Biomolecualr condensates with logos for species (human, frog, mouse), c-mods with chemical compound logo, DNA, proteins, RNA minimalistic logos.

CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...

The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.

Silja used rhodamine probes for protein labeling in cells

Tony giving the plenary on phase separation in physiology and disease

Silja receiving her price for her Master's thesis

Koichiro talking about spatial control of P granules

We had a good line up of speakers at the 50 years anniversary meeting of the german society of cell biology @dgz.bsky.social in Heidelberg. Tony gave the plenary, Koichiro talked about spatial control of P granules and Silja received a price for her Master thesis and gave a talk. Congratulations!

Congratulations to our PhD student David @rnadavid.bsky.social for his successful defense of his PhD thesis! @mpi-cbg.de imprs.mpi-cbg.de
As you see the lab was very creative with his hat! David gave his insights on the nucleocapsid protein and even better arranged a great buffet for celebrations!

link doesn't work ;-)

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

how about giving citations?

🤌

Dresdner Forscher gewinnen besonderen Nobelpreis für Pastasauce Kuriose wissenschaftliche Studien sind mit den Ig-Nobelpreisen in den USA geehrt worden. Auch Forscher vom Max-Planck-Institut in Dresden wurden ausgezeichnet.

Very good news in the local press! The Ig Nobel goes to Dresden 😎

www.saechsische.de/lokales/dres...

Have a look at Lars @larshubatsch.bsky.social reviewed preprint in @elife.bsky.social and learn about the kinetics of molecule transport across interfaces of condensates!

Congratulations to Patrick and his team!
Tremendous work carried out over the last years @mpi-cbg.de and @poldresden.bsky.social as collaboration between Hyman lab, Brugues lab and Andrei Shevchenko

This is an amazing piece of work! It was a true pleasure seeing this story come together.
@mpi-cbg.de going on a streak of @nature.com papers!

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro | PNAS MEX-5 regulates the formation and dissolution of P granules in Caenorhabditis elegans embryos, yet the thermodynamic basis of its activity remains ...

The recent publication from MtL fellow @hymanlab.bsky.social has described a quantitative framework for condensate stability and dissolution, in the context of RNA binding protein MEX-5 and P-granules. Congratulations to MtL Student Silja Zedlitz for being a co-author!
www.pnas.org/doi/10.1073/...

Novel Research in Biological Artificial Intelligence Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

How to spy on condensates - Nature Methods Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks.

How to spy on condensates: technology feature in @natmethods.nature.com on self-organization and collective properties of condensates with quotes from Anthony Hyman @hymanlab.bsky.social @mpi-cbg.de, @brangwynnelab.bsky.social, and many more. www.nature.com/articles/s41...

Dresden scientists @thegutmann.bsky.social and @rnadavid.bsky.social from the @hymanlab.bsky.social discover a new strategy used by the SARS-CoV-2 virus to hide from the body’s DNA immune detection system. Now published in @pnas.org. www.mpi-cbg.de/news-outreac...

How could SARS-COV-2 evade detection by host cells?

Read the new paper from Theresia @thegutmann.bsky.social
and David @rnadavid.bsky.social discussing how the nucleocapsid protein prevents recognition of the innate immunity sensor cGAS

Congratulations!!!
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Big news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️

Visit us during the Dresden Science Night on June 20th in the Faculty of Physics @tudresden.bsky.social (Hermann-Krone-Bau, Nöthnitzer Straße 61) and explore the physics of life! Looking forward to see you! www.mpi-cbg.de/news-outreac...

We're excited to welcome Dresden's scientific community to the GBM Compact Meeting in Frankfurt! #CodensateBiology
gbm-compact.org

The german research foundation DFG will fund the new graduate school for

"Biomolecular Condensates: from physics to biological function" here in Dresden

This new graduate school is part of 18 new graduate schools funded by the DFG in germany!

The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩

Big #thankyou to all the participants from
@hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜

We had great fun with the lab!

Condensates Inside Condensates—Triggering Disease? New Insights into TDP-43 Condensation and Neurodegeneration

Condensates Inside Condensates—Triggering Disease?
New Insights into TDP-43 Condensation and Neurodegeneration. Publication from the @hymanlab.bsky.social in @cellpress.bsky.social, first author: @xiaoyan52802927.bsky.social www.mpi-cbg.de/news-outreac...

YouTube video by MPI-CBG Molecule Disarms Cellular Stress Granules Linked to ALS

Watch the related Science Sketch video: youtu.be/uBpPMyVTj5c?..., created by @marionamec.bsky.social

Molecule Disarms Cellular Stress Granules Linked to ALS Discovery by researchers in Dresden and Edinburgh points to new understanding of the onset of ALS.

A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...

"targeting intra-condensate demixing of TDP-43 within stress granules, as a distinct step to aggregation, becomes a potential avenue for therapeutic intervention"

"Our key finding is that TDP-43 aggregation requires a double event. One event is the increase in TDP-43 con- centration within stress granules surpassing a critical threshold, and the other is oxidative stress promoting TDP-43 self-interaction"