Vini John

Please add me!

Timing Exposure to Microbes

Time for the August episode of the #MucosalMonday MI Podcast featuring a discussion with @michael-silverman.bsky.social, @marionbrunck.bsky.social, and Agnes Garcias Lopez; Medical mystery from @ashu-mangalam.bsky.social; and MI research with @kknoop.bsky.social open.spotify.com/show/0Q4Ve1x...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling in this work from @saraalonsomera.bsky.social @edelblumlab.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.

🔗 ow.ly/rwMU50Wy3Mp

#AAIRESTORE

CIRM Trainee Networking Conference career panel sessions discussing their experiences and personal journeys of having a career in regernative medicine.

It’s great to hear about the various career paths in the #RegenerativeMedicine field—from R&D and lab work to policy and #SciComms. Thank you to our panelists for sharing their experiences and insights. #CIRMTraineeConference

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice - Nature Communications Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meni...

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

#gdTcells @natcomms.nature.com

The perfect end to a great #gammadeltatoronto conference: our latest review has just been published in Advances in Immunology!

"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"

👉🏼 authors.elsevier.com/a/1l8ltErwXf...

#gdTcells @forum-gd.bsky.social

Happy #FluorescenceFriday!

Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

Secretory IgM regulates gut microbiota homeostasis and metabolism @natmicrobiol.nature.com
www.nature.com/articles/s41...

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

Check out this paper on the role of ACC1 in γδT17 cells in vivo in a psoriatic mouse model #gdtcells

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
www.nature.com/articles/s41...
@natimmunol.bsky.social

If you are at #AAI25 in Hawaii and interested in learning about intestinal epithelial and IEL crosstalk. Please do stop by my poster # 1107 today from 10:30-11:45am.
Session Title: MUC6P -Regulation of Mucosal Immunity.
@squeakyanimal.bsky.social #Immunology2025

The Parse team is presenting one more scientific poster this morning at @aai.org! Meet us at board 1187 at 10:30 to learn about how Evercode technology as the only all-in-one solution for humanized transgenic mice.
www.parsebiosciences.com/aai-2025/

1/ My group is at #IMMUNOLOGY2025 presenting our research. For those of you following along from home I want to share 1 min videos of each presenting their posters. @PaigeSHansen did an incredible job here presenting her about Lyme disease and gynepathologies.

#ICYMI scenes from #IMMUNOLOGY2025™ from Saturday, May 3!

#AAI2025

Aloha!🌺 Super excited for another year at #Immunology2025 representing the Chu Lab👩🏻‍🔬 @chulab.bsky.social
This time I’ll be sharing the induction of pro-inflammatory responses by B. fragilis isolated from an IBD patient👀
Want to hear all about it? Stop by poster #1046☕️
#LatinaInSTEM

Can't make it to #IMMUNOLOGY2025?

Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️

Our first daily episode will be released on May 4. Stay tuned!

#AAI2025

Excited to participate in the 2025 annual American Association of Immunologists meeting in Honolulu 🏝️
Looking forward to seeing my colleagues and learning about the latest advances in immunology.
#AAI2025 and #Immunology2025
@aai.org

ICOS+CD4 T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis
@jci-insight.bsky.social
insight.jci.org/articles/vie...

Heading to #IMMUNOLOGY2025™? Want to maximize your experience? Join our webinar for insider tips on scientific highlights, networking in our new MHC collaboration zones, social events, and more. Register now and ask your questions live: ow.ly/veEt50Vv9Iq. #Immunology

Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.

Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!

#MicroSky #MicrobiomeSky 🦠

www.nature.com/articles/s41...

#APS2025 starts in three weeks! We're excited to share some programming highlights, including our #NobelLaureate and prestigious award winners who are keynote speakers, and our game-changer sessions. Read more: ow.ly/Re2950VtNTa #WeArePhysiology🧪

Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.

Super proud of my former lab mate and friend. It’s been amazing to witness this journey from the very beginning to the grand finale hehehe. Thrilled to be a part of it-Congratulations, Sree! ☺️ 🎉🎉🎉

www.nature.com/articles/s41...

📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling @edelblumlab.bsky.social
doi.org/10.1101/2025...

It's here! Check out the latest Mucosal Immunology Podcast featuring Dr. Cecilia Johansson from Imperial College London, and solve the new Medical Mystery from Ashu Mangalam. 🩺✨

🎧 Tune in now: socmucimm.org/resources/mu...

#MucosalMonday
@mucosalimmunol.bsky.social

two men are riding a bicycle with a basket on it . ALT: two men are riding a bicycle with a basket on it .

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis
www.science.org/doi/10.1126/...
@nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social