Kilian Schober

Congrats, Dominic!

Thanks a lot! Unfortunately our barcodes and UMIs are not on the same read, therefore this possibility probably won't work, but we'll look into it.

Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.

The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.

tl;dr it's glam-slop & everyone involved should be embarrassed

Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠

Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:

🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology

Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

Find an overview in this thread. 🧵👇

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Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1

Together with Ralf Bartenschlager @ciid-heidelberg.bsky.social we are looking for a PhD student!

The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity.

Contact us if you're interested!
#PhDPosition

📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...

Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social

www.biorxiv.org/content/10.1...

In her free time Eva enjoys hiking, horse riding, listening to audiobooks and spending time with family and friends.

Welcome, Eva!

Want to find out more about our team? Visit us here: www.schoberlab.de/team

@fau.de

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Eva Brunner joins us as a new PhD student.

Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis.

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LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

© HIRI / Sandy Westermann (SCIGRAPHIX)

Happy World #CRISPR Day, everyone! ✂️🧬

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis shows a favorable safety profile, depletion of plasma cells in the central nervous system, and alleviation of mic...

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | NEJM In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi...

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....

How do you synthesize so many TCRs? Invest lots of money and go commercial or do you have one of the new cloning platforms set up?

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

Nurture over nature in fate decisions of antigen-specific CD8+ T cell clones from an endogenous repertoire Abdullah et al.1 recently set out to gauge the influence of T cell receptor (TCR)-intrinsic vs. -extrinsic factors on memory vs. effector fate decisions of CD8+ T cells. They concluded that “a majorit...

Nature or nurture? See www.cell.com/immunity/pdf... in response to www.cell.com/immunity/pdf..., with this reply by the original authors: www.cell.com/action/showP.... We need more "letter arguments" in science on platforms with high visibility. Through critical debate we gain critical insight.

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells
www.biorxiv.org/content/10.1...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

The image depicts a line chart illustrating child mortality rates, specifically the estimated percentage of newborns who do not survive past the age of five. The chart has two distinct lines: one representing Sweden in blue and the other representing South Korea in red. Starting in the early 1800s, the blue line for Sweden shows a gradual decline in the child mortality rate, fluctuating around 35% at the beginning and continuing to decrease steadily over the years, reaching nearly 0% by 2023. In contrast, the red line for South Korea begins more steeply in the mid-20th century, experiencing a rapid decline after 1950, ultimately approaching a very low percentage by 2023. The sources for the data are listed at the bottom as Gapminder (2015) and the UN Inter-agency Group for Child Mortality Estimation (2025). The entire chart is labeled as CC BY for Creative Commons licensing.

Declining child mortality, fast and slow

This is up to us!

Does #bluesky still #exist or is it #dead?

CAR-T-Zell-Therapie erstmals bei schwerer Darmerkrankung erfolgreich Einem Ärzteteam am Deutschen Zentrum Immuntherapie des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter…

Einem Ärzteteam des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter, schwerer chronisch-entzündlicher Darmerkrankung erfolgreich mit einer CAR-T-Zell-Therapie zu behandeln.

Mehr erfahren: go.fau.de/1cb-e

TCR activation impairs CAR-T cytotoxicity against separate target cells https://www.biorxiv.org/content/10.1101/2025.10.07.680634v1

@fau.de, @helmholtzmunich.bsky.social, @uni-magdeburg.de, @tum.de, @uni-wuerzburg.de, @badw.de, #BMFTR, @dfg.de, @ekfstiftung.bsky.social, @yellow4flavi.bsky.social.