Mark Hedglin

A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities Abstract. During replication, lagging strand lesions are initially encountered by high-fidelity DNA polymerase (pol) holoenzymes comprised of pol δ and the

So happy & excited to see this out. An honest & sincere thank you to the editor & reviewers for their constructive criticism & feedback that helped bring the best version of this story to life!
doi.org/10.1093/nar/...

From cooperation to conflicts – a complicated relationship between transcription and replication. A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…

Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...

#3 Chemistry PhD defense from the lab was a success. Congratulations Dr. Rachel Dannenberg, PhD!! We are so very proud of you & excited for your future. Thank you for your unwavering dedication, determination, grit & everlasting footprint on the lab.

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!

Register Today: emgs-us.org/event/OxiDNA...

Research mentors, "unofficial" mentors within the PSU & greater scientific community, colleagues, former lab mates. Thank you all so much.

This is a credit to all past & present lab members whose hard work, dedication, & scientific intrigue made this dream a reality. Also, a credit to SO many along the way (too many to mention by name) that provided unwavering support, motivation, & inspiration.

Penn State announces tenure-line faculty promotions, effective July 1, 2025 | Penn State University The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2025.

It's official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories from within such an amazing community.

Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬

Register Today: emgs-us.org/event/OxiDNAWEB

Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR Nature Communications - CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay...

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium!

🕛 Thursday 17 April at 12pm US Eastern time

👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol

Register here: lnkd.in/eRxxSxeu

#NARCancer #PARPInhibitors #DNARepair #GenomicStability

Sorry to hear that. Any luck yet? DM if there is still a problem.

Thanks Josh!!

Another great collaboration with the @professorantony.bsky.social lab.

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published!

Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.

www.nature.com/articles/s41...

Why does yeast replication require two alternative clamp loaders?
Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC
www.embopress.org/doi/full/10....

Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibi...

Exciting new preprint led by @glowingtelomeres.bsky.social reveals how 6-thio-dG (THIO drug) targets telomeres in cancers. This drug “traps” telomerase in a non-productive state to prevent telomere lengthening and cancer cell growth. www.biorxiv.org/content/10.1...

Symposium speakers and title

NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...

We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below!

jobs.virginia.edu/us/en/job/R0...

Dear all,

Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

Hello BlueSky!!