Laboratory of Genomic Stability

Chromosomes in rainbow colors inside blue nuclei on a black background

👋Our April issue's out!
Cover: Live #chromosome tracking

👉🏼Perspective on #lactylation
👉🏼Review on #MechanicalForces in development
🔬 #MyocardialInfarction #PreclinicalStudy #NeuralStemCells #proteostasis #neurodegeneration #mitochondria #CellDeath #cancer & more!
www.nature.com/ncb/volumes/...

16.04.2025 13:22 — 👍 24    🔁 3    💬 0    📌 0

I would like to be added. Thanks!

21.04.2025 15:04 — 👍 1    🔁 0    💬 1    📌 0

Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ

13.11.2024 17:55 — 👍 84    🔁 42    💬 41    📌 0

Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: <loops> are generally rare (2.3%)

www.biorxiv.org/content/10.1...

16.01.2025 13:35 — 👍 151    🔁 64    💬 6    📌 2

Here we can see how #centrosome motion contributes directly to chromosome redistribution.

07.04.2025 13:04 — 👍 6    🔁 0    💬 0    📌 0

Dynamics of intra- and inter- chromosomal contacts during mitosis with 8-second resolution

07.04.2025 13:02 — 👍 3    🔁 0    💬 1    📌 0

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

07.04.2025 13:01 — 👍 67    🔁 27    💬 1    📌 2