TDvaliLab

Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...

Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

C. elegans: An elegant experimental system for the study of cilia biology Caenorhabditis elegans is a genetically tractable organism that has become one of the leading in vivo models for cilia research. Cilia are not require…

My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too.
www.sciencedirect.com/science/arti...

Our 7th Cellbio Minisymposium was super fun (as always)!

Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀
www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!

little reminder: a few days left to apply for one of the #DGZ awards!

Promising #cellbiology & related science to be seen & discussed in October in Heidelberg - join us! Registration still possible until Sept 15.

Drosophila picticornis, a Hawaiian fly with patterned wings

Wish I could be at #Evol2025 this year! I’ll be starting a new lab at NYU this fall, and will be recruiting at all levels. Please spread the word if you know anyone who wants to work on evo. genomics, phylogenies, and comparative development of inverts (like Hawaiian Drosophila!) shchurch.github.io

We're thrilled to announce that our Excellence Cluster Physics of Life (PoL) has been renewed for a second funding phase (2026-2032) by @dfg.de ! Thanks to everyone who made this possible! 🎉👏

We'll continue our cutting-edge research towards understanding what brings matter to life!
#biophysics #dfg

Actin sun.

Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors The authors show that anillin mediates unilateral cytokinesis by blocking the effector binding site of active RhoA. The interaction between active RhoA and

Anillin links up with RhoA to break the symmetry of cytokinetic ring closure.
Guillaume Chambaud, Vlad Martin, and Gilles Hickson @chusaintejustine.bsky.social discuss work from Lebedev et al. @zaninlab.bsky.social (doi.org/10.1083/jcb....) in Spotlight: rupress.org/jcb/article/...

#Cytokinesis

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...

Pachinger, Dammermann et al. @maxperutzlabs.bsky.social‬ present a model for centriolar satellites not as transport modules but as sites of translation specifically of centrosomal and ciliary proteins. rupress.org/jcb/article/...

#centrosomes #cilia

US researchers must stand up to protect freedoms, not just funding Curtailment of freedoms and disregard for the rule of law in the United States is destroying the ability of science to serve the nation’s, and the world’s, interests. Researchers can take action.

New op-ed in @nature.com: The Trump administration's assault on freedoms and the rule of law is an existential threat to US science. We urge scientists to speak out in defense of freedoms, not just funding. With Andrea Liu @upenn.edu and Sidney Nagel of UChicago! www.nature.com/articles/d41...

Thanks for speaking up!!!

Want to learn more about our work on Anillin during cytokinesis? Check out the Spotlight from the Hickson Lab!

A bit late… but was a nice dinner!

Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans - PubMed In mammals, cohesin and CTCF organize the 3D genome into topologically associating domains (TADs) to regulate communication between <i>cis</i>-regulatory elements. Many organisms, including <i>S. cere...

our latest work summary: cohesin is preferentially loaded at/near active enhancers and loop extrudes in both directions, forming loops that create the dna contacts that appear as the newly defined "fountains" in hic maps pubmed.ncbi.nlm.nih.gov/40210441/

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and #cytokinesis completion. New study from Kuheli Adhikary, Sukriti Kapoor, and Sachin Kotak (Indian Institute of Science Bangalore): rupress.org/jcb/article/...

#Development #CellDivision #Celegans

A PhD position is available in my lab at the University of Geneva to explore the interaction between gut microbes and behavior in social bees. Please share with potential candidates. Application deadline: May 25th. More info and how to apply: tinyurl.com/PhDmgbee

Happy to transition to this platform to discuss science and share our fascination.

The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).

(Kroll et al, EMBO J 2023)

Congrats, great work!

We are excited to share our latest work on the role of anillin during unilateral cytokinesis. Congratulations to Mikhail, the leading author, for his excellent work. Big thanks to the @tdvalilab.bsky.social lab for their tremendous support.

Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors The authors show that anillin mediates unilateral cytokinesis by blocking the effector binding site of active RhoA. The interaction between active RhoA and

Congratulations to Mikhail, Esther, and the whole team @zaninlab.bsky.social ! - Check it out! rupress.org/jcb/article-...

Poster with DGZ 2025 Meeting details (speakers list, organizers, sponsors)

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Sign!

Rally Poster with the Stature of Liberty

NC friends of science. Join me tomorrow in Raleigh on Halifax Mall by the State Capitol for the Stand Up For Science Rally--talks begin at 12:30. Let's remind our neighbors and our politicians that science solves societal problems, develops disease treatments and creates jobs! 🧪 Please share

A plug that my lab is currently recruiting a postdoc. 5 years of funding, the lab has steady funding for the next 8 years, and no active attempts to burn down the scientific enterprise in your potential new home.. Plus the occasional bagpipe player rocking a kilt on the street.

I have one open PhD position. Maybe one of the last PhD positions in the lab as I'm planning changes in what we do and how we will do it some five years from now. I'm offering freedom (pun intended), respect, an interesting project, and a good full time contract w. health insurance.

6 more weeks to apply !

Become our new colleague at the Cell Biology Dpt and join the growing group of junior teams of @i2bcparissaclay.bsky.social shaping the scientific environment of the institute.

Apply if you are looking for a place to start a lab or forward to any potential candidates.