José María Santos-Pereira

Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids This EMBO Workshop explores the gene-regulatory mechanisms that drive developmental reprogramming upon fertilization. It focuses on the interplay of transcriptional, post-transcriptional, and develop…

Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!

Super cool work! Congrats!

Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression

www.biorxiv.org/content/10.1...

Dear all, PLEASE add comments on the importance of model organism research at this link:

Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!

Registration is open! join us October 17th at @cabimer.bsky.social
in our #ConexiónGenoma. WorkShop! Limited spots avaible. Abstract submission possible for Poster Presentation or Oral Communication.

Congratulations to the new PhD: María José López! Dr. López presented and discussed her PhD work marvellously! María José's thesis was done with @geneticsub.bsky.social co-supervised by Nacho Maeso from @geneticsub.bsky.social & @malmuedocas.bsky.social from #CABD

CellTalk HHD | Human Heart Development Research CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.

🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)

If you are attending #EMBLChromatin, go and check @mariamafau.bsky.social poster and learn more about how ZIC2 controls neural induction and patterning by playing a dual and sequential regulatory role.

@ibis-investigacion.bsky.social @unisevilla.bsky.social

Ready to start the #EMBLChromatin Workshop in beautiful Heidelberg and enjoy a lot of fantastic science!

Massively parallel characterization of transcriptional regulatory elements - Nature Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

Published in today's issue! OPEN ACCESS article, FREE massive dataset, FREE code, FREE pre-trained AI/ML model. #OpenScience was a mountain of work to make this happen: check it out if you haven't already 😉

Dos escutoides, uno verde y uno amarillo

Buscamos una persona candidata para solicitar un contrato predoctoral #FPU2024. Posibilidades para gente experimental o computacional para trabajar en alguno de nuestros proyectos.
Os dejo aquí la convocatoria. Se agradece mucho la difusión. (sigue)

www.ciencia.gob.es/Convocatoria...

Congrats Rafa, María and team!

🚨🚨🚨

If you're a bioinformatician who loves:

🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! 🙏

Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding?

Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social

www.sciencedirect.com/science/arti...

The chromosome folding problem and how cells solve it All cells must fold their chromosomes. The combined action of a small set of conserved molecular and biophysical mechanisms fold chromosomes in a variety of ways across the cell cycle and tree of life. We are increasingly understanding more about how chromosome structure relates to genome functions.

Such a nice review!! 🙌
www.cell.com/cell/fulltex...

We’re recruiting a PhD student to use comparative omics to investigate why some viruses can efficiently infect both human and mosquito cells, but lead to different infection outcomes. Fully funded position by @evomg-bcn.bsky.social at our lab at UPF-CRG and the Diez lab.

www.crg.eu/en/content/t...

Enhancer cooperativity can compensate for loss of activity over large genomic distances Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex regulatory landscapes. Integrating the same enhancer at different distances from a promoter uncovered that activ...

Enhancer cooperativity can compensate for loss of activity over large genomic distances | Molecular Cell

#chromatin #enhancers

www.cell.com/molecular-ce...

Thank you!

This method is really cool 👇🏼

Great, thanks a lot!

Hi! Thanks for the packs! Could you please add me too?

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La Sociedad Española de Bioquímica y Biología Molecular también abre su cuenta en @bsky.app A partir de ahora también publicitaremos y comentaremos nuestras actividades a través de este nuevo canal de comunicación del cielo azul.
sebbm.es

Looking to satisfy your fish fix? Begin with one of our Starter Packs covering the #zebrafish community: 🐟🧪

PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY

PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF

Early-Career Researchers/Trainees: go.bsky.app/HwxuHey