David Kuster

'This is scientifically incredibly fascinating to have an entire field that's built on a technical limitation.':D

YouTube video by Physical Properties of the Cytoplasm Physical Properties of the Cytoplasm Seminar Series #25 | Allan Drummond

Very insightful reconsideration what Stress Granules might actually be good for!

Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.

Amazing talk & scholarship by @drummondlab.bsky.social!

youtu.be/caAPToh8v0Q

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

UT Southwestern researcher receives NIH Director’s New Innovator Award David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...

Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?

In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!

www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

Structural insights into mitotic-centrosome assembly https://www.biorxiv.org/content/10.1101/2025.10.03.680336v1

Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶‍♂️'s CDK5RAP2.

Translation landscape of stress granules Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!

pubs.rsc.org/en/content/a...

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Frog drank the tea, and then he said, “Tell me a story while I am resting.”

PDB101: Molecule of the Month: Amyloids Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

September 21 is #WorldAlzheimersDay
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!

www.molbiolcell.org/doi/full/10....

Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social

And huge thank you @ascbiology.bsky.social

Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.

Let’s be clear about what happened to Jimmy Kimmel Trump’s most brazen attack on free speech yet.

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

In another exciting development our new preprint is online:
www.biorxiv.org/cgi/content/...

This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Paper alert!🧪
We derive a theory that underpins interface resistance with a physical foundation and look at how it changes droplet growth and recovery kinetics! Awesome collab with @bosste.bsky.social Tyler Harmon @hymanlab.bsky.social @m-pol.bsky.social and Frank Jülicher @mpipks.bsky.social 1/4

That's probably at the heart of why the world shifts towards populism & ultimately facism..

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

What a pleasure to collaborate with Laura #Schaedel and her team at @uni-saarland.de to study #microtubule damage and repair under mechanical load.

Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.

Our Autumn PhD call is OPEN!
20+ fully funded positions across diverse life science disciplines. Explore projects in Cell & Chromosome biology + more 👉 www.vbcphd.at

Apply by 10 Oct 2025

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Why is AI struggling to discover new drugs? A generation of start-ups have failed to live up to the hype. Executives are now betting that more powerful tools will crack the complexities of human biology

Damn, if only someone had predicted this.
www.ft.com/content/9a8a...

Tau accelerates tubulin exchange in the microtubule lattice - Nature Physics Beyond its known role in stabilizing microtubules, it is now shown that tau protein actively promotes lattice defect repair by enhancing tubulin turnover at topological defects.

Excited to share that my paper on Tau–Microtubule interactions is now published in Nature Physics!🎉

Our work shows that tau goes beyond stabilizing microtubules—it also promotes the removal of defects in the microtubule lattice.

www.nature.com/articles/s41...