David Kuster

A vision of chromosome organization Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure

@science.org 🧬🔬 A vision of #chromosome organization | Science www.science.org/doi/10.1126/...
@vram142.bsky.social et al.

Super excited to share that our paper is now out in @science.org. Lots of work, but also lots of fun getting this out.
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social

Inaugural lecture to the faculty of Yasin Dagdas (@plantophagy.bsky.social) and Simon Wiegert (@simwieg.bsky.social) - bridging green and red biology.

Just one week away until #CellBio2025!

Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium!

Dec 10 at 9 AM

@ascbiology.bsky.social

Super excited to contribute to this special interest subgroup!!! Thank you for this opportunity, Abby and Iain!

Cheap Computation of Small Peptide Binders

How well does free software work to design peptide binders? It depends:

A Bullfinch perches neatly on a dark branch, its bright coral-red chest glowing against the soft grey background. Its black cap and stout bill give it a look of quiet confidence (as if it knows it’s the most striking bird in your feed today).

Oooh aren't you lucky! A Bullfinch is perched in your feed... 😍

📷 @vickyoutenphoto.bsky.social

Join us next sunday for a wonderful discussion!! #PlanetaryCellBiology @gladfelterlab.bsky.social @gautamdey.bsky.social @mpolychronidou.bsky.social @karlaneugebauer.bsky.social

🥳 Thrilled, honored & very happy to become part of the amazing EMBO Young Investigator Programme! Looking forward to the new opportunities, interactions, ideas & collaborations it will spark. Very grateful to my fantastic team @mpi-cbg.de, colleagues, collaborators & mentors who made this possible!

Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier - Nature Cell Biology Kozai, Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shape...

www.nature.com/articles/s41...

Shapeshifting gates guard the cell nucleus An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...

🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉
www.biozentrum.unibas.ch/news/detail/...

We’re excited to welcome the TREC community to EMBL Heidelberg for a three-day Symposium.

The event brings together researchers across disciplines to exchange insights, spark new ideas, and strengthen connections within the TREC network: www.embl.org/about/info/t...

Talk titles for IDPSeminars on Dec 4th at noon central time. Alex Holehouse (Washington University in St. Louis): Sequence-to-ensemble with STARLING Birthe Kragelund (University of Copenhagen): Disordered protein complexes and the origins of life

We're back for our final seminar of 2025 with talks from @alexholehouse.bsky.social and Birthe Kragelund! 1 pm EST or 7 pm European time. If you're not already signed up, head on over to idpseminars.com to register!

I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩

TDP-43 controls RNA structure through high affinity lattice interactions TDP-43 is an RNA binding protein implicated in neurodegenerative disease. TDP-43 binds to GU dinucleotide repeats, which are highly abundant sequences in human RNA. Here we show TDP- 43 has one of the...

New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work!

www.biorxiv.org/content/10.1...

Our #SciComm booth at LA Comic-Con was all about the science behind #Pokémon! It was a joy to see people of all ages engaging with our activities and creating DNA jewelry. Thank you @afroherper.bsky.social, @cosplayforscience.bsky.social, IF/THEN and the Ecologik Institute for this collaboration ❤️

Many thanks to @fpmaragall.bsky.social for this great opportunity! Together with Natalia Rodríguez Muela’s group at @dzne.science in Dresden, we’ll explore triggers and inhibitors of the earliest steps in Alzheimer’s disease progression.
bsky.app/profile/fpma...

Truly honored to receive the STS Science Award as recognition from the Signal Transduction Society! I am grateful for the support of my mentor Tony Hyman @hymanlab.bsky.social, institutional support @mpi-cbg.de, and funding by the @dfg.de and the NOMIS Foundation.

🌟G&D SPOTLIGHT 🌟

REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract

#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates

We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...

It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.

@tothpetroczylab.bsky.social :)

YouTube video by MPI-CBG Protein plasticity and evolution: The research group of Agnes Toth-Petroczy at MPI-CBG

Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...

𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐧 𝐫𝐞𝐜𝐞𝐢𝐯𝐢𝐧𝐠 𝐭𝐡𝐞 𝐒𝐓𝐒 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐀𝐰𝐚𝐫𝐝 2025! 🎉
At the 28th STS Meeting in Weimar Theresia Gutmann @thegutmann.bsky.social was honored with this award, which recognizes outstanding research by postdocs or junior PIs within the STS. Congratulations! @mpi-cbg.de #STS #CellCommSummit

📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social

www.cell.com/cell/fulltex...

Key findings in a thread (1/6):

See how far a PhD from @cellbiol-mrclmb.bsky.social can take you! Still a few days left to apply for a PhD place here to start in October 2026: www2.mrc-lmb.cam.ac.uk/students/int...

Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...

Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...

☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW

🔔Join us next Wednesday for #FragileNucleosome! 2 fantastic talks on chromatin regulation:🔬 @mariamafau.bsky.social on ZIC2's dual role in neural induction 🔬 @jhenninger.bsky.social on how RNA-binding proteins drive transcription
📋Register here for the entire series: us06web.zoom.us/webinar/regi...

Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs Glauninger, Bard, Wong Hickernell, et al. reveal that stress causes transcriptome-wide mRNP condensation, largely independent of length and often without stress granule formation, but newly synthesize...

Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs - new from @drummondlab.bsky.social www.cell.com/molecular-ce...