Stephan Wilmes

🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...

17.10.2025 15:18 — 👍 11    🔁 12    💬 0    📌 0

Huge thanks to all involved, including but not limited to
@jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @nartimsoole.bsky.social @arnemoeller.bsky.social

02.09.2025 20:02 — 👍 2    🔁 0    💬 0    📌 0

With a combination of #cryo-EM, biochemical, biophysical and in vivo data we show what contributes to substrate and target membrane specificity and reveal a function of the third subunit of the metazoan MC1 GEF, RMC1/Bulli.

02.09.2025 20:02 — 👍 1    🔁 0    💬 1    📌 0

Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.

Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....

02.09.2025 20:02 — 👍 7    🔁 4    💬 2    📌 0

Always found it odd we were never thaught how to assess publications. Of course your experiences, discussion and reading loads are key, but I think a reminder on Master's level that not everything you come across in literature can be taken for granted and what to look for would help lots of students

09.08.2025 18:39 — 👍 1    🔁 0    💬 1    📌 0

CryoSift – An accessible and automated CNN-driven tool for cryo-EM 2D class selection

Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN

01.08.2025 15:20 — 👍 17    🔁 7    💬 1    📌 0

Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelit...

Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025...
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social

06.04.2025 21:54 — 👍 4    🔁 0    💬 0    📌 0

Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1

29.03.2025 04:46 — 👍 4    🔁 3    💬 0    📌 0

Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1 The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus

Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1

26.11.2024 03:46 — 👍 3    🔁 1    💬 0    📌 0