Prof G

Nitrofurantoin warning: please read Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs.

#MS_Selfie Newsletter - Nitrofurantoin warning: please read

Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL

Which formulation of HRT would you recommend? "It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.”

#MS_Selfie: Which formulation of HRT would you recommend?

"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN

Q&A 118: ECTRIMS 2025 & CAR T-cells I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties.

#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells

I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU

Q&A 117: ECTRIMS 2025 - EBV & MS If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? gavingiovannoni.substack.com/p/q-and-a-11...

Q&A 117: ECTRIMS 2025 - EBV & MS If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?

#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM

ECTRIMS 2025: blowing my own horn The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive.

#MS_Selfie ECTRIMS 2025: blowing my own horn

The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw

Q&A 116: which antiviral? There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS ....

#MS_Selfie Q&A 116: Which antiviral?

There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv

What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql

Prof G's response to the AI-generated newsletter One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.

One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology. gavingiovannoni.substack.com/p/prof-gs-re...

Prof G's response to the AI-generated newsletter One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.

#MS_Selfie - Prof G's response to the AI-generated newsletter

Q&A 115: AHSCT or not? Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis.

#MS_Selfie Q&A 115: AHSCT or not?

Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp

How useful is AI-generated content in the field of MS? I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question:

#MS_Selfie: How useful is AI-generated content in the field of MS?

I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6

Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments?

#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists

If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI

Q&A 113: Should I take creatine supplements? If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life?

#MS_Selfie Q&A 113: Should I take creatine supplements?

If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy

Burnout RX: HCP's silent struggle Burnout RX—the hidden social and economic costs of a silent crisis among healthcare professionals

Burnout RX: HCP's silent struggle impact.economist.com/health/healt...

Energy drinks vs. Coffee Are you self-medicating MS-related symptoms using energy drinks or coffee?

#MS_Selfie - Energy drinks vs. Coffee

Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za

Q&A 112: Latent TB If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

GAVIN GIOVANNONI gavingiovannoni.substack.com/p/q-and-a-11...

Q&A 112: Latent TB If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

#MS_Selfie Q&A 112: Latent TB

Q&A 111: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) Should I start tirzepatide or semaglutide to treat my MS?

#MS_Seflie Q&A 111 (a Nelson): Glucagon-like peptide-1 receptor agonists (GLP-1RAs)

Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS Women's Health & Research MS is finally getting the recognition it deserves.

Women's Health & Research MS is finally getting the recognition it deserves. gavingiovannoni.substack.com/p/dr-kristen...

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS Women's Health & Research MS is finally getting the recognition it deserves.

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS

Q&A 110: Anxiety and MS If you have a significant problem with anxiety and/or depression, please discuss this with your HCP. Simply living with anxiety and depression as a ‘new normal’ is not a solution.

#MS_Selfie Q&A 110: Anxiety and MS

If you have a significant problem with anxiety and/or depression, please discuss this with your HCP. Simply living with anxiety and depression as a ‘new normal’ is not a solution. buff.ly/3VAmZVZ

Q&A 109: Antivirals as treatment for MS I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals?

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals? gavingiovannoni.substack.com/p/q-and-a-10...

Q&A 109: Antivirals as treatment for MS I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals?

#MS_Selfie Q&A 109: Antivirals as treatment for MS

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals? buff.ly/N88fBfB

Q&A 108: Dairy Sensitivity and MS I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps.

I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps. gavingiovannoni.substack.com/p/q-and-a-10...

Q&A 108: Dairy Sensitivity and MS I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps.

#MS_Selfie Newsletter - Q&A 108: Dairy Sensitivity and MS

I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps. => buff.ly/DXuPiwj

Q&A 107: a new AI-generated classification system for MS progression Including an AI-generated podcast to describe the research underpinning this classification system.

Including an AI-generated podcast to describe the research underpinning this classification system. gavingiovannoni.substack.com/p/q-and-a-10...

Q&A 107: a new AI-generated classification system for MS progression Including an AI-generated podcast to describe the research underpinning this classification system.

#MS_Selfie Q&A 107: a new AI-generated classification system for MS progression. Including an AI-generated podcast to describe the research underpinning this classification system. => gavingiovannoni.substack.com/p/q-and-a-10...

Does MS-Selfie have a future? Am I making the lives of my colleagues, including general practitioners (GPs), more difficult and for creating unrealistic expectations of what can be realistically offered to people with MS?

#MS_Selfie - Does MS-Selfie have a future?

Am I making the lives of my colleagues, including general practitioners (GPs), more difficult and creating unrealistic expectations of what can be realistically offered to people with MS? buff.ly/fCubjcb

#MS_Selfie - Recurring UTIs - some non-antibiotic solutions

How many of you have been taught how to self-manage your bladder to prevent UTIs?

buff.ly/5WwcoJB