King Lab

@uwproteindesign.bsky.social Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!

22.08.2025 21:15 — 👍 1    🔁 0    💬 0    📌 0

From sequence to scaffold: computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and du...

Another day, another preprint on @biorxivpreprint.bsky.social!

Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...

22.08.2025 17:29 — 👍 6    🔁 3    💬 0    📌 0

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...

🚨 New paper alert! 🚨

Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

04.08.2025 17:48 — 👍 23    🔁 7    💬 0    📌 1

Creating multi-protein systems with atomic precision – Institute for Protein Design Protein design is expanding from building single molecules to generating entire systems from scratch with parts that work together in ways nature never explored.

You can also learn more in the most recent @uwproteindesign.bsky.social blog post: www.ipd.uw.edu/2025/08/crea...

01.08.2025 21:24 — 👍 2    🔁 0    💬 0    📌 0

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

01.08.2025 21:22 — 👍 30    🔁 12    💬 1    📌 0

@uwproteindesign.bsky.social We’re looking for early stage investigators (Sr. Postdocs, Instructors, Asst Profs, etc) to join our ReVAMPP Center designing vaccines and antibodies against paramyxoviruses and bunyaviruses! Read more and apply here: tinyurl.com/MLvax-ESI-app

01.08.2025 21:19 — 👍 2    🔁 0    💬 0    📌 0

UW Human Resources University of Washington Human Resources

The IPD is hiring a new Assistant to the Director! This role provides complex administrative support to IPD leadership and is crucial to keeping operations running. Apply today! bit.ly/4kyguvn

09.07.2025 20:20 — 👍 0    🔁 1    💬 0    📌 0

Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccine research at NIAID’s Vaccine Research Center.

27.06.2025 21:44 — 👍 4    🔁 0    💬 0    📌 0

Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens - npj Vaccines npj Vaccines - Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens

🚨 new paper alert 🚨

Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform!

This collaborative project was led by Dr. Mark Langowski
and is out now in npj Vaccines: www.nature.com/articles/s41...

27.06.2025 21:43 — 👍 7    🔁 4    💬 0    📌 0

There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳

Congratulations on all your hard work Dr. Criswell!

06.06.2025 21:12 — 👍 2    🔁 0    💬 0    📌 0

Our very own Grace Hendricks gave an excellent talk about her work on mRNA-launched nanoparticles at the Keystone Symposium on Vaccinology in Washington, DC today!

05.06.2025 21:52 — 👍 3    🔁 0    💬 0    📌 0

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines Vaccines against emerging SARS-CoV-2 variants and sarbecoviruses with pandemic potential must elicit a robust humoral immune response in a population imprinted with the SARS-CoV-2 spike (S) protein. H...

Delighted to share our most recent work on designing broadly protective sarbecovirus vaccines and defining the path forward for other coronaviruses.

Led by @aminaddetia.bsky.social

@hhmi.org

www.biorxiv.org/content/10.1...

14.05.2025 14:21 — 👍 11    🔁 6    💬 1    📌 0

On Monday the lab celebrated "Cinco de Cara" in honor of Dr. Cara Chao successfully defending her PhD thesis! 🥂

In addition to making MERS vaccines, Cara is a beloved member of the lab who often shares tasty baked goods and infectious laughter.

Congratulations!

08.05.2025 22:02 — 👍 4    🔁 0    💬 1    📌 0

UW Human Resources University of Washington Human Resources

The IPD is hiring a new Executive Director! This senior leadership role guides institutional strategy, builds research partnerships, drives fundraising, and directs operations at the world’s top center for computational protein design. Apply today! bit.ly/3Z99PA1

08.05.2025 21:48 — 👍 3    🔁 0    💬 0    📌 0

Enjoying the cherry blossoms and blue skies in Seattle today 🌞

04.04.2025 22:10 — 👍 7    🔁 0    💬 0    📌 0