Iswar Hariharan

When echinoid (ed) mutant clones (white) and wild-type twin clones (red) are generated in the developing Drosophila eye (right), the mutant tissue is eliminated. However, if wild-type twin clones are removed so that most eye tissue is mutant (left), the ed mutant cells survive and the eyes overgrow. See Research Article by Spitzer et al.

Issue 15 is complete!

On the cover: When echinoid (ed) mutant clones (white) and wild-type twin clones (red) are generated in the developing Drosophila eye (right), the mutant tissue is eliminated. See Research Article by Spitzer et al.

journals.biologists.com/dev/article/...

My PhD work from @hariharanlab.bsky.social is finally out in @dev-journal.bsky.social! We investigated an interesting paradox: how can reduced function of the adhesion molecule Echinoid (Ed) cause seemingly opposite phenotypes—overgrowth and elimination—in different contexts? (1/8)

Fig.3. echinoid clones are generated and then die, especially when more wild-type tissue is present. (A-F) Wing discs containing GFP-marked clones expressing either UAS-w-RNAi (A,C,E) or UAS-ed-RNAi (B,D,F). Heat shocks of 12 min (A,B), 15 min (C,D) and 30 min (E,F) generate clones at progressively higher density. Scale bar in H applies to H-K. Scale bar in A applies to A-F.

The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.

Read this #OA Research Article by Danielle Spitzer
@dspitzer.bsky.social , William Sun, Anthony Rodríguez-Vargas, and Iswar Hariharan:

journals.biologists.com/dev/article/...

….just as a pair of Forster’s Terns are hunting over the adjoining bay.

A pair of United Airlines planes (Boeing 737-900 and Airbus A321-neo) landing on parallel runways at SFO…

Black oystercatcher!

Starling feeding a big insect to the juvenile

This alarm clock cannot be adjusted for the time change! Good thing is that when she tries to wake me up tomorrow it will already be 6.30 am and not 5.30 am.

A purple-rumped sunbird in her amazingly-constructed nest.

Single cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location https://www.biorxiv.org/content/10.1101/2024.12.10.627868v1

CONGRATULATIONS TO GUKESH, THE NEW WORLD CHAMPION 🏆

The 18-year-old Indian star has defeated the reigning champion, Ding Liren, to become the youngest-ever undisputed classical chess world champion. Wow! 🇮🇳

After walking one mile up a steep street this morning, this sign struck a chord.

Happy New Year!!! Spent part of today photographing Sandhill cranes.

Sandhill cranes in flight. Staten Island, California.

Today is the 136th birth anniversary of the amazing mathematician Srinivasa Ramanujan - celebrated as National Mathematics Day in India. Maybe every country should have their own National Mathematics Day.

My first post on Bluesky. Appropriately, a Great BLUE Heron.