Seth Dickey

Do you use artificial intelligence or machine learning in your research? Do you want to work in the vibrant DC metro area? Please consider applying for the open Assistant Professor position at UMD in College Park, Maryland. @umdscience.bsky.social

umd.wd1.myworkdayjobs.com/UMCP/job/Uni...

And a special shout out to the trainees who made essential contributions, including @dburgin.bsky.social n.bsky.social (now in the Bernhardtlab @harvardmed.bsky.social y.social) and Ama Antwi at @univofmaryland.bsky.social.

Many thanks to all co-authors, especially to Michael Otto at #NIAID. This work spanned my postdoc in the Otto Lab
and into my independent position at the @univofmaryland.bsky.social nd.bsky.social where we are continuing the work @umdscience.bsky.social.

Overall, TMcin behave in ways like other small #antimicrobialpeptides as a monomer but more like the much larger pore-forming proteins as oligomers.

How does TMcin remain soluble with a TM helix? We discovered two strategies: 1) as a monomer, TMcin has a loop with beta-strand structure that folds over the TM helix, making the whole peptide amphipathic, and 2) S. aureus PSMs peptides act as surfactants to further solubilize TMcins.

Why would a bacteriocin possess a hydrophobic TM helix?

We proposed that the TM helix allow TMcins to assemble stable and large beta-barrel pores anchored in cell membranes by the surrounding TM helices.

We discovered the TMcin family in a rare cluster of #Staphylococcusaureus isolates but TMcin is found widely among Gram-positive bacteria.

TMcin has broad activity against Gram-positive bacteria including (non-TMcin-producing) #MRSA and #VRE.

We named it TMcin for transmembrane-helix containing bacteriocin.

Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices Nature Communications - Bacteriocins include antimicrobial peptides (AMPs) that often disrupt the cytoplasmic membrane. Here, the authors describe TMcin (transmembrane helix-containing...

We found a new #bacteriocin family that forms large pores using transmembrane helices!

#MicroSky #antimicrobialpeptide #RiPP

rdcu.be/ezuY1

Give to Vet Med Graduate Scholarship Fund | Giving Day I’m ready to support Vet Med Graduate Scholarship Fund on March 5, 2025 during Giving Day. Learn more about Vet Med Graduate Scholarship Fund

3/ Vet Med Graduate Scholarship Fund – Investing in the education and success of our veterinary medicine graduate students.

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2/ Basil and Anne Hatziolos Scholarship for Veterinary Medicine Research – Empowering the next generation of researchers advancing veterinary science.

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1/ Veterinary Medicine Discretionary Fund – Providing critical support where it’s needed most, from student initiatives to groundbreaking research.

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Give to Veterinary Medicine Discretionary Fund | Giving Day I’m ready to support Veterinary Medicine Discretionary Fund on March 5, 2025 during Giving Day. Learn more about Veterinary Medicine Discretionary Fund

It's Giving Day at the University of Maryland. If you believe in the work our Department of Veterinary Medicine does and what to support it or our students, please donate!

There are three ways to give.

👇

Document Search Results for '"Drug Discovery and Molecular Pharmacology A"' Search, browse and learn about the Federal Register. Federal Register 2.0 is the unofficial daily publication for rules, proposed rules, and notices of Federal agencies and organizations, as well as e...

DMPA meeting in March is not on the Federal Register.

www.federalregister.gov/documents/se...

@washingtonpost.com @ddiamond.bsky.social

Disappointed to see no coverage in today's paper on the reduction in force at HHS that occurred on Friday. Not even in the Metro section.

Our department is looking for a Director of Administrative Services. We're in College Park inside the DC beltway.

umd.wd1.myworkdayjobs.com/en-US/UMCP/j...

3/ Hopefully this will make it clear to more what we stand to lose, and have lost, by the wholesale dismantling of government agencies and withdrawal from global collaborations.

2/ Organizations try to achieve this with communications departments. But they don't have the reach into the public who live different lives. Individuals who know the good being done - maybe because they're the ones doing it! - can simply provide examples on their social media platforms.

1/ We need a #UNSEENGOOD campaign. There's a lot of misinformation and cherry picking of bad apples (I'll own that mixed metaphor). I believe many people who don't interact with governments and organizations do not hear about the good work being done and this leads to reputational harm.

Donate to WHO’s Emergency Response Health Can’t Wait. Your Support Saves Lives Today.

Putting together a lecture on AMR for students and now I'm inspired to go and work for the WHO. A vivid reminder of what we stand to lose.

donate.who.foundation

For those (me!) trying to submit a grant today with eRA commons down, you can submit a help ticket to show good faith effort to submit so that your application (hopefully) is not considered late.

grants.nih.gov/grants-proce...