Marcus Goncalves

A health-system-scale, episode-resolved multimodal atlas of cancer cachexia Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood. H...

The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @edreznik.bsky.social redefines what we know about human cachexia integrating genetics, lab values, and treatment lines. www.medrxiv.org/content/10.1...

I’m proud to share that diabetes & endocrinology at @nyulangone has been ranked #4 in the U.S. by @usnews!

Not to miss this week: Beyond Mammals: Exploring Cancer Models Webinar Series. Thursday, May 22, from 1:00 – 2:15 PM ET events.cancer.gov/dcb/beyond-m...

Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models - British Journal of Cancer British Journal of Cancer - Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models

Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models www.nature.com/articles/s41...

A figure showing the mechanisms that regulate glucagon secretion.

This Review from Phillip J. White, Nicolai J. Wewer Albrechtsen & Jonathan E. Campbell explores islet hormones at the intersection of glucose and amino acid metabolism (£) go.nature.com/3S26jDE
#EndoSky #WorldHormoneDay #BecauseHormonesMatter

DFS 0161 CGC Discover mag 2024 A year of scientific creativity

The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!

Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges

features.cancerresearchuk.org/cancergrandc...

Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states Trinh et al. demonstrate that basal IL-6 activity regulates fat uptake and storage. IL-6 enhances skeletal muscle fat uptake, promotes fat release from subcutaneous adipose tissue during fasting, and ...

IL-6 regulates fat and muscle lipid metabolism in humans www.cell.com/cell-reports...

Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...

Changes in neurotensin signalling drive hedonic devaluation in obesity www.nature.com/articles/s41...

We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:

Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)

Please circulate 🔁

events.nyas.org/event/16a78a...

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎

Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

Images in Clinical Medicine Exogenous Lipoid Pneumonia Panel A: High-resolution CT of the chest. Panel B: A photo of yellow secretions observed in the bronchial lumen during bronchoscopy. Panel C: The secretions separated out in the bronchoalveolar-lavage (BAL) fluid. Panel D: Cytologic examination of the BAL fluid showing lipid-laden macrophages and extracellular droplets of oil. Panel E: Histopathological analysis of a lung-biopsy specimen showing numerous macrophages phagocytosing lipid droplets.

A 38-year-old woman with a history of disordered eating was found to have ground-glass opacities on a chest CT. Cytologic examination of bronchoalveolar-lavage fluid showed lipid-laden macrophages and droplets of oil. Full case details: nej.md/428CqI5

#MedSky #PulmSky

Call to Improve Coding of Cancer-Associated Cachexia | JCO Oncology Practice Cachexia is a systemic wasting syndrome prevalent in patients with cancer that significantly affects quality of life, health care costs, and therapeutic outcomes. Despite its clinical importance, cach...

Cachexia is rarely diagnosed and coded, which undermines clinical care. Today, we release a Call to Improve Coding of Cancer-Associated Cachexia ascopubs.org/doi/10.1200/...

Cancer Metabolism and Signaling 2025

The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...

A brain circuit that links hunger signals with the jaw movements of eating In mice, silencing a set of neurons in the brain’s hypothalamus leads to chewing behaviours, even when food is unavailable.

This is very cool. Brain circuit that regulates chewing www.nature.com/articles/d41...

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer www.nature.com/articles/s41...

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

GLP-1/leptin dual agonist

The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025

Loving this jam packed AACR tumor body interactions meeting!

FDA commissioner: We need action and higher-quality research on ultra-processed foods “Researchers, public health and health care groups, advocates, industry, and the public must put tackling diet-related disease at the top of their priority list.”

Let’s support Bipartisan calls for better diet research