Böckmann Lab

Wie Impfstoff-gefüllte Fetttröpfchen ihre Fracht entlassen Wenn die Lipidnanopartikel bei Aufnahme in die Zelle in eine saure Umgebung gelangen, organisieren sie ihre Hülle grundlegend um, zeigt eine Studie der FAU.

Das Video zeigt, wie sich die Hülle des Fetttröpfchens bei Änderung des Umgebungs-pH-Werts nach und nach umorganisiert. Positiv geladene Aminolipide sind blau dargestellt, ungeladene Aminolipide gelb.

Mehr erfahren: www.fau.de/2026/01/news... (2/2)

Impfstoffe und andere Medikamente werden zum Schutz oft in kleinen Fetttröpfchen verpackt, den sogenannten Lipid-Nanopartikeln. So werden sie von den Zellen aufgenommen und entlassen erst dann ihre Fracht. Um diesen Prozess zu optimieren, haben FAU-Forschende den Vorgang am Computer simuliert. (1/2)

Today, we painted all corridors in our labs as a group effort with LOTS of help from others from the department biology @fau.de Thanks to @biomemphys.bsky.social @zaninlab.bsky.social, the cellbio and department admin for joining. It was a great effort with perfect result 🙏💪🍀

Ein Park, der schneebedeckt ist. Eine Person geht in der Ferne durch den Schnee.

Heute am besten lieber mit Schlittenhunden zur Uni fahren 🐕‍🦺

Now in Small: pH-dependent remodeling of #LNP membranes.
#Constant-pH MD reveals effect of LNP-lipids on the LNP #pKa.
Video: Membrane remodeling from pH 5 → pH 7
Blue = charged aminolipids | Yellow = neutral | Green = cholesterol
#lipids @fau.de @m-a-r-i-u-s.bsky.social
doi.org/10.1002/smll...

Ein grosser Spaß - jederzeit wieder in unserem Dream Team!

Rückblick "Cooking for Climate"

Rückblick "Cooking for Climate" https://www.green-office.fau.de/2025/12/11/rueckblick-cooking-for-climate/

Want to learn constant-pH MD simulations hands-on in GROMACS? Apply now for our workshop: “GROMACS for Constant-pH MD Simulations” in Erlangen @fau.de @m-a-r-i-u-s.bsky.social

Public Climate School 2025 @ FAU Die Public Climate School (PCS) ist eine Aktionswoche, in der deutschlandweit vom 24. bis 30. November Bildungseinrichtungen Teile ihres Lehrprogramms so gestalten, dass sie Themen rund um die…

🥘🌍 Cooking for Climate bei der #PublicClimateSchool 🤓😋
Heute in der Mensa Langemarckplatz.
Ihr werdet staunen, wer dort gerade für euch kocht! (Was?! Um 6:30 fangen sie an?) Echte Profs aus der Biologie @nat.fau.de, Essensausgabe ab 11:00 mit @biomemphys.bsky.social und @fuhrmannlab.bsky.social

Alle Studierende und Beschäftigte aus NAT und PHIL sollten morgen zu den Krisenversammlungen gehen und sich für eine bessere Gebäudesituation an der FAU einsetzen!

Tenure-track Position in Biophysics at Carnegie Mellon University, Department of Physics Location: Pittsburgh, PA Open Date: Sep 19, 2025 Description The Department of Physics at Carnegie Mellon University invites applications for a tenure-track faculty position in biophysics. The appointment is intended to be at the Assistant Professor level, but exceptional candidates at a higher level may also be considered. We seek outstanding candidates with a strong record in cellular and subcellular biophysics. Topics of particular interest include, but are not limited to, uncovering how key characteristics of living systems arise from the interplay between supramolecular cellular structures, how the emergent cellular circuitry defines goals and enables robust decision making, and how metabolic resources are allocated. This encompasses understanding of how information is learned, stored, transduced, and processed across subcellular structures. Applicants with theoretical, data science, or experimental backgrounds within biological physics are encouraged to apply. The ideal candidate will strengthen and extend research programs of current biophysics faculty in the Department of Physics and collaborate with broader life science activities across many departments at CMU and the wider Pittsburgh area. More details on Interfolio: https://apply.interfolio.com/174360

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪

Interfolio link: apply.interfolio.com/174360

PLEASE, share widely across the blue skies!

Let me briefly explain what we're looking for:

1/10

Flammkuchentag in @biomemphys.bsky.social Lab @fau.de

Phantastic work by Marius on aminolipids and how they are affected by their environment! Stay tuned! @fau.de

I was pleasured to present our latest Research on titratable aminolipids at the 3rd NHR conference! 😊
#HPC #science #simulations #phd

😁

3rd #AMPeL Meeting on antimicrobial peptides, this time at @fau.de, in inspiring environment of Villa Jordan, a guest house at FAU. Many thanks to Gutsmann, Grünewald and Eggeling Labs for stimulating collaboration, and @leibniz-gemeinschaft.de for support!

Great start of our AMPEL meeting @fau.de @m-a-r-i-u-s.bsky.social

The lecture will take place at MPZPM. It will also be streamed via Zoom, as well as recorded and added to our YouTube channel for anyone who misses the talk. ▶️ Radical bursts from tissue stretch? New mechanobiology uncovered by experiments and AI 🕒 Thursday, September 18 at 3 pm CET 📍 Seminar Room 0.125 at the Max-Planck-Zentrum für Physik und Medizin, Erlangen

Lectures on Physics and Medicine

Prof. Frauke Gräter, Director at the Max Planck Institute for Polymer Research in Mainz, will give her fascinating talk on September 18 at 3 pm CET.

👉 Zoom access:

eu02web.zoom-x.de/j/6249564969...
Meeting-ID: 624 9564 9691
Identification code: 582716

An Editor of some high-impact Journal asking for data from a mouse model - in an all-atom simulation study… Our answer:

Die Vorbereitungen zur Langen Nacht der Wissenschaften am 25. Oktober laufen an…
#LNdW2025 @fau.de

We're hiring! Join our team at @fau.de ! We are seeking an enthusiastic candidate for a PhD position in our lab specializing in cutting-edge theoretical and computational membrane biophysics.
Please send your CV, and a statement of research interests via email.
www.biomemphys.nat.fau.de/jobs/

Teamassistenz für die Arbeitsgruppe Computational Biology (m/w/d)

Wir suchen Dich!
Die AG Computational Biology @fau.de sucht ab Jan 2026 eine Teamassistenz (m/w/d, 50% TV-L E 8).
Organisation, Verwaltung & Kommunikation sind dein Ding? Dann bewirb dich bis 16.09.2025!
👉 Mehr Infos:
www.jobs.fau.de/jobs/teamass...

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology...

Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab, @biomemphys.bsky.social, and Thisbe Lindhorst!

pubs.acs.org/doi/abs/10.1...

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology. While research in this field has revealed its tremendous importance in ever more aspects of physiological and pathological cellular processes, many of the principles that govern the role of the glycocalyx in these processes on a molecular level are still unknown. In order to unravel the fundamental laws underlying glycocalyx function, new technologies are required that enable the distinction between individual subprocesses within the intricate environment of the glycocalyx. Here, we establish an experimental platform to investigate the dynamics of the glycocalyx at the nanometer and microsecond length and time scales in a bottom-up fashion. We synthesized defined oligosaccharides and installed them on supported lipid bilayers. This way, synthetic glycolipids were assembled to glycocalyx model systems with tunable properties. By investigating these tunable model systems with interferometric scattering (iSCAT) microscopy, we gain access to the required spatiotemporal resolution. We found a strong correlation between the molecular structure of several investigated model glycans and global dynamics of the system. Our findings are corroborated by atomistic molecular dynamics simulations and coarse-grained Brownian dynamics simulations. Our results provide the first direct experimental evidence on the relationship between glycan structure, organization, and dynamics, offering a robust and versatile basis for a quantitative understanding of glycocalyx biology and physics at the molecular level.

🔔
Excited to share our latest work on the dynamics of synthetic glycolipids in model membranes! 🤩
@biomemphys.bsky.social!

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy | Journal of the American Chemical Society pubs.acs.org/doi/full/10....

Structure of a LNP-mimetic system at pH 7 containing mRNA.

🔔🔔🔔
We’ve updated our article “Decoding pH-Driven Phase Transition of Lipid Nanoparticles” on bioRxiv!
The cpHMD simulations now cover longer timescales, and we added new simulations with the molecule TNS. Could it modulate the surface charge?
Read the full story:
www.biorxiv.org/content/10.1...

Extracellular vesicles Aiming to boost the exploitation of extracellular vesicles in drug delivery, this collection is open to original research across all delivery aspect of EVs.

I am guest editing a #ExtracellularVesicles collection in Scientific Reports @natureportfolio.nature.com 👇 Submissions will be welcomed at any point up until 15th February 2026.

www.nature.com/collections/...

Hier nochmal die Pressemeldung im Wortlaut 👇

🚀 Biologie, Physik & Mathematik – alles in einem Studium!
🎓 Integrated Life Sciences (ILS) an der FAU: Von Zellbiologie & Programmieren bis zu Big-Data-Analyse und moderner Mikroskopie.
📅 Bewerben bis 15. August auf www.campo.fau.de – sichere dir deinen Studienplatz! @fau.de
#FAU #ILS #LifeSciences

More excellent news: also Paolo Rossetti of @biomemphys.bsky.social won a poster award at #EBSA2025! He presented his atlas of bacterial membrane structure & dynamics @fau.de

Big congrats to Marius @m-a-r-i-u-s.bsky.social for winning a poster award at the #EBSA2025 congress! Well deserved!! Constant pH applied to lipid nanoparticles is cool! @fau.de