Pagès lab's Avatar

Pagès lab

@pageslab.bsky.social

DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast

511 Followers  |  187 Following  |  5 Posts  |  Joined: 04.10.2023  |  1.4152

Latest posts by pageslab.bsky.social on Bluesky

Post image

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs !

🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social

👉 @narjournal.bsky.social
buff.ly/rVeGV9B

11.04.2025 15:04 — 👍 4    🔁 4    💬 0    📌 0

Thanks Annabel!

25.03.2025 05:53 — 👍 0    🔁 0    💬 0    📌 0

Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS

24.03.2025 10:42 — 👍 3    🔁 0    💬 0    📌 0
Post image

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability.
doi.org/10.1093/nar/...

24.03.2025 10:42 — 👍 12    🔁 6    💬 4    📌 0
Post image

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis.
https://buff.ly/3Xbgjxd

25.02.2025 10:17 — 👍 3    🔁 1    💬 0    📌 0
Post image

Recruiting a postdoc to work on our yeast project

17.12.2024 12:41 — 👍 3    🔁 1    💬 0    📌 0

@pageslab is following 20 prominent accounts