Anirudh Jakhmola

Me seeing the price of booking the cryo-EM for 3 days.

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

Now engineering phages with Anirudh Jakhmola from @robfagan.bsky.social lab at @sheffielduni.bsky.social #3cdf

Thank you to all participants for making the 2nd #3CdF such a fantastic event! See you next year for the next one! #microsky 🧪 #Cdiff

High-throughput screening reveals diverse lambdoid prophage inducers Prophages; dormant bacteriophage genomes integrated within the bacterial chromosome, play pivotal roles in shaping microbial communities when awakened. Our current understanding of prophage activation...

Prophage induction - nice study, inducers other than MitC, but also that inducer concentration matters. Search for optimum needed to get highest titers ☝️
www.biorxiv.org/content/10.1...

Good ol’ homologous recombination!

Signed title page of “Everything is Tuberculosis” by author John Green

Managed to nab a signed copy of Everything is Tuberculosis by @johngreensbluesky.bsky.social. Quite excited to read this.

The mutagenesis gods were with us this week.

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

The do’s and don’ts of scientific image editing

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

@sarareardon.bsky.social reports

www.nature.com/articles/d41...

3CdF 2025 Fourwaves - 3CdF 2025

Happy to announce 2nd #3CdF Cross-channel C. difficile Forum in Newcastle, June 4-5 for #Cdiff researchers from UK, France and Europe, w/ strong emphasis on ECRs! Thanks to @microbiologysociety.org support!
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky

Pip can be a physicist if that’s her thing. I bet she’ll be a good physicist.

A TEM image of a bacteriophage with a burst head and a broken tail tube

Screening some mutant phages and can’t help but feel bad about this guy who:

1. Had his head burst (Red selection is where the head was supposed to be)
2. Tail tube broke in half

RIP unnamed phage. You will be missed.

I wanna know how Toby feels about this. 😂

Extinction is permanent.

Let’s goooo!!

Me standing in front of my poster titled “Targeted structural engineering to understand phage host interactions”

Presented my work in the Science Graduate Showcase at the University of Sheffield. A bit subtle in design compared to my past posters but there’s always tomorrow. #phage

Molecular mechanism of bacteriophage contraction structure of an S-layer–penetrating bacteriophage The molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous S-l...

New paper alert 🚨
We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance

www.life-science-alliance.org/content/8/6/...

Error message saying: server sent GOAWAY and closed the connection

NCBI has the most sassy server I’ve ever come across. What do you mean that the error code is NO_ERROR? Real helpful NCBI.

Rob holding a four week old (very fluffy!) yellow Labrador retriever

Introducing Pip! 4 weeks old and doing brilliantly

Village house with cobbled veranda.

Village view with goats in the foreground and houses in the back.

Mountain view of Uttarakhand, India

Green mountains with the himalayas peeking from behind

Spending the last few days at my home and I can never get used to this view. The himalayan range in the background steals the show.

Pretty curious about the phage diversity here though.

Sand sculpture of Homi Bhabha with “DAE CONCLAVE” written.

Back at NISER to catch up with my old lab and friends. One thing that always amazes me is the sand art.

Being back in India has rejuvenated my hatred towards high beams and people driving with high beams in the middle of the night. I had forgotten how annoying those are.

An international team of scientists has launched 115TB of validated scientific data to enable AI breakthroughs across disciplines! Two huge open-source datasets across dozens of fields, from bacteria to supernova!
The Well: github.com/PolymathicAI...
Multimodal Universe: github.com/MultimodalUn...

Found this absolute gem of an arrangement at Manchester Airport

‘Silly and pompous’: Official new names for viruses rile up researchers An overhaul of viruses’ scientific naming system has incensed some virologists, but others are more accepting

I can't see these names being adopted in the short to medium term. I certainly won't be insisting on their use.

Just keep in mind that creation of new names doesn't formally ban old ones. So whatever facilitates clearest communication is best.

www.science.org/content/arti...

Lungi, the white and tan dog wearing a red bandana and looking all confused.

Lungi, the white and tan dog looking back cause he is camera shy wearing his red bandana.

You know you have a big dog when the bandana you got him from UK marked specifically for “large adult dogs” looks like this.

Time to bust out the ol’ towel and make a bandana out of it.

Group photo of Sheffield’s Structural Group

Successfully scaled the Win Hill in the Peak District while casually chatting about unkillable superbugs… ya’know… like normal people.

The 4 stages of any experiment

I still can’t believe it is you.

Managed to run ChimeraX on a Meta Quest VR headset and working with protein structures is a lot more fun now.