Bisrat Debeb

Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

Trump Administration Scraps Effort to Pause Health-Research Funding The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

New Science story about multi-year funding and it potential catastrophic consequences

www.science.org/content/arti...

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Penny Pritzker Warns Trump Cuts Threaten US in Global Tech Race President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said Penny Pritzker, former US commerce secretary and chair of Harvard University’s powerful governing body.

President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

Fay: Cuts to research funding risk the collapse of U.S. science and technology I started as an assistant professor of molecular biology at the University of Wyoming in 2001.

“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.”

Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com

Funding scientific research is the only way we will cure cancer • Pennsylvania Capital-Star The proposed federal budget for next year includes a 55% cut to the National Science Foundation (NSF) and a 44% cut to National Institutes of Health (NIH).

Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...

Pan-cancer human brain metastases atlas at single-cell resolution Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. T...

Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...

Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.

Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.

See 7:15 below. Full Senate appropriations committee meets tomorrow about it.

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Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.

Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later.

Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer

Congrats!

After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️

@dalimartinez.bsky.social 🧪

Important research on IBC that can also benefit understanding other types of aggressive #breastcancer

Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky

Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social

Importantly, we show that sEcad remodels the brain microenvironment by promoting reactive astrocytes through the CXCL1–CXCR2 axis; blocking this pathway reduced brain metastasis burden and prolonged mouse survival.

Using novel IBC brain metastasis models, we show that sEcad drives brain metastasis by impacting multiple steps of the metastatic cascade, including invasion, anoikis resistance, endothelial adhesion, and BBB transmigration.

We describe novel tumor cell-intrinsic and - extrinsic mechanisms by which soluble E-cadherin (sEcad) promotes brain metastatic growth in aggressive breast cancers. Serum sEcad levels are correlated with increased development of brain metastasis and death in breast cancer patients.

Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2

👉 biorxiv.org/content/10.110…

Vanderbilt University Medical Center to lay off up to 650 after Trump administration grant cuts • Tennessee Lookout Vanderbilt University Medical Center, expects to lay off 650 employees as a result of grant and funding cuts by the Trump Administration,

Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.

Trump’s Cuts to Science Funding Could Hurt U.S. Economy, Study Shows Reducing federal support for research and development could cause long-run economic damage and reduce government revenue.

The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth.

Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:

Rapid Response Bridge Funding Program In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants.

www.spencer.org/grant_types/...

Meeting the Moment Together We are returning from the AERA Annual Meeting in Denver reinvigorated and with a deep appreciation for all that scholars and higher education leaders are holding in this moment. Rapid shifts in fed...

FYI “Spencer Foundation, Alfred P. Sloan Foundation, William T. Grant Foundation and Kapor Foundation are providing quick turnaround grants of up to $25k for education scholars impacted by the abrupt NSF grant cancellations.” www.spencer.org/news/meeting...

Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.

Congratulations Drs Woodward and Lynce on developing a new #IBC scoring system to improve IBC diagnosis. #IBCdiagnosis

Development of a Multi-Institutional Dataset to Validate a Novel Inflammatory Breast Cancer Diagnostic Score AbstractPurpose. Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinician

Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...

Exclusive | Top Vaccine Official Out at FDA In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.

A huge loss at FDA.
Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...

How does exercise and fitness promote healthy brain aging?
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...