IGFL

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale

apply here: www.averof-lab.org/pages/tracman

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Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux!

www.ens-lyon.fr/indexation/a...

Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏

So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏

cc @ensdelyon.bsky.social

Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.

Flyer announcing a seminar by Jean Livet from the Institut de la Vision, hosted by Jonathan Enriquez at IGFL Lyon on June 30th, 2025. The talk is titled “Topography and topology in a central sensory neuronal projection.” The abstract explains that in the vertebrate brain, sensory pathways connect neuronal relays with high precision over long distances. To study these circuits, dense single-neuron tracing and large-volume microscopy are used. Jean Livet will discuss their efforts in connectomic mapping using multicolor labeling, focusing on an auditory relay to reveal its topographical and topological organization. The flyer also includes a short bio: Jean Livet completed his PhD on motor neuron development at IBDM Marseille, developed the Brainbow labeling method during his postdoc with Jeff W. Lichtman in the USA, and has led the “neurogenesis and circuit development” team at the Institut de la Vision since 2008.

Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨

Cartoon of Steven Van Belleghem riding a giant beetle over green islands, holding a camera and flying scientific papers. A hawk and butterfly accompany him, symbolizing his evolutionary genomics research on butterflies, Daphnia, and beetles.

🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics

🧬 From genomes to pangenomes to adaptation!
Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐

Live now at IGFL: Laure Bally-Cuif (Institut Pasteur) is sharing her fascinating work on the heterogeneity of adult neural stem cells. A deep dive into brain plasticity in action! #Neuroscience #IGFL #StemCells
@zenlabpasteur.bsky.social

Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons | PNAS During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose ident...

Congrats to Dr. Laurie Nemoz Billet for earning an Accessit 2025 from @sfbd.bsky.social for her thesis on the role of the ECM in motor nerve development and regeneration in zebrafish! A brilliant contribution to the field. Read more: www.pnas.org/doi/10.1073/... 🎉

🧠 Seminar alert! Laure Bally-Cuif (Pasteur Institute) will present:
"Individual cell heterogeneities and population dynamics for adult neural stem cell maintenance"
She will show how neural stem cell sub-populations sustain neurogenesis in zebrafish.
📅 05/05/25, 11am, Salle Condorcet ENS Lyon

Time to go mad! Thank you @zaycha.bsky.social for inviting @mads100tist.bsky.social for exciting science on somatosensory neuron diversity.

IGFL will be going mad next Monday, when we host @mads100tist.bsky.social, directly from Basel! We are looking forward to hearing an exciting talk!

Today BioSymposium of the 4 research units at @ensdelyon.bsky.social
Great mix of PI and Doc/Postdoc presentations and posters with some live musics tonight
@igflyon.bsky.social
@lbmcinlyon.bsky.social
@ciri-lyon.bsky.social
and RDP (not yet on Bluesky I think)

Very excited to host the one and only @mads100tist.bsky.social at @igflyon.bsky.social in Lyon on April 7th! Don't hesitate to pass by for his talk if you're in the city, it promises to be a real treat!

The drosophila brain

Guest lecture today on Drosophila brain metabolism. Exciting results by Prof. Stefanie Schirmeier from TU Dresden.

Title of the presentation Metabolic flexibility of the Drosophila nervous system Short abstract Neuronal function consumes large amounts of energy. This energy needs to be provided in order to maintain homeostasis. To deal with this disproportionate demand, glial cells support neurons metabolically. Like their mammalian counterparts, Drosophila glial cells are very glycolytically active and provide lactate to the neurons under optimal conditions. Upon suboptimal conditions, several aspects of brain metabolism can be adapted. On the one hand, nutrient uptake into the nervous system is regulated to ensure nervous system function. On the other hand, glial cellular metabolism can adapt to changing conditions. E.g. when carbohydrate supply is not sufficient to meet the metabolic needs of the neurons, the glial cells switch to ß-oxidation of fatty acids and produce ketone bodies as an alternate fuel that they supply to neurons. It turns out that glial metabolism can be adapted to different conditions, like starvation or cold exposure, in different ways to ensure neuronal function. Short CV Stefanie Schirmeier graduated from the University of Bayreuth (Germany) and joined Dominique Ferrandon’s team at the University of Strasbourg (France), where she studied host-pathogen interactions using Drosophila melanogaster as a model. She contributed to a genome-wide genetic screen and discovered the compensatory proliferation of intestinal stem cells in response to gut infection, as well as identifying a bacterial virulence factor required to counteract the cellular immune response. She then moved to the University of Münster (Germany) for a postdoctoral position, joining Christian Klämbt’s team and later establishing her own research group there. Stefanie focused on investigating the physiology and metabolism of glial cells and uncovered their role in neuronal nutritional support via the astrocyte-neuron lactate shuttle. Since 2021, Stefanie has been a professor at Dresden Technic…

Seminar alert! 🧠🔬 Prof. Stefanie Schirmeier (TU Dresden) presents "Metabolic flexibility of the Drosophila nervous system" on March 17th, 11 am at Salle Condorcet. Explore glial cells & adaptive metabolism! #Neuroscience #Metabolism

YouTube video by CNRS François Leulier, du microbiote aux mécanismes de croissance l TalentsCNRS

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#TalentsCNRS 🥈 | Découvrez le portrait vidéo de François Leulier, médaille d'argent 2024 du @cnrs.fr, chercheur en biologie et directeur de @igflyon.bsky.social

@cnrsbiologie.bsky.social @ensdelyon.bsky.social @francoisleulier.bsky.social
🎬👇
www.youtube.com/watch?v=QKOk...

Big news at IGFL! We’re thrilled to have two MSCA postdocs this year!
@ludivinebertonnier.bsky.social (Heude lab) dives into sarcomagenesis through neck development.
@luciebernard.bsky.social (Leulier lab) uncovers how early-life nutrition shapes immunity.
Exciting science ahead!

Yesterday, IGFL hosted its first Equality Breakfast with Lucie Marchal (CNRS DR07). We tackled the myth that “we can’t say anything here!”—sexist jokes aren’t just jokes; they’re part of GBV. A great turnout showed IGFL’s commitment to inclusion. Let’s keep working for equality! #Equality #Inclusion

Suboptimal refeeding compensates stunting in a mouse model of juvenile malnutrition Early postnatal life is a critical period of rapid growth in mammals, heavily reliant on adequate nutrition. Protein-energy malnutrition (PEM) during …

1/ 🚨 Excited to share our new study, now published in The Journal of Nutrition! We developed a mouse model of juvenile protein-energy malnutrition (PEM) to assess growth recovery after refeeding with optimal or suboptimal diets.
🧵
www.sciencedirect.com/science/arti...

🌱 New findings on kelp zygotes! Bénédicte Charrier’s team shows how alginate forms a corset, shaping early cell fate.

🔬 Read the Scientific Reports paper: www.nature.com/articles/s41...

🖼️ Kelp zygote: alginate corset (green), nucleus (blue), chloroplasts (red). Length: 30 µm.

Thank you @cnrs.bsky.social
@cnrsbiologie.bsky.social for this medal which recognizes the excellence of the work of my lab members over the last 10 years at @igflyon.bsky.social @ENSLyon, an amazing place for discovery science in #EvoDevoPhysio

Congratulations @francoisleulier.bsky.social for being awarded the CNRS Silver Medal for your exceptional scientific achievements!

Co-option of neck muscles supported the vertebrate water-to-land transition - Nature Communications The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...

👏 Big congrats to Eglantine Heude et al. for their amazing work in @naturecomms.bsky.social!
Tracing the origins of the tetrapod neck, they show how fish muscles were co-opted for land life. Evolutionary innovation at its finest! #EvoDevo
www.nature.com/articles/s41...

Happy @igflyon.bsky.social SAB members and Group leaders!!! 2 intense but very productive days.

Congratulations @francoisleulier.bsky.social, recipient of the Jaffé Prize - Fondation de l'Institut de France. This award honors work or experiences aimed at advancing progress and the well-being of humanity.