SFBD_BioDev

Developmental Biology lost a giant yesterday 😔
May his legacy thrive and keep inspiring current and future generations of scientists

www.gurdon.cam.ac.uk/nobel-laurea...

Development cover: Embryonic eye of an anole lizard stained for nuclei (DAPI, blue) and F-actin (Phalloidin, orange), imaged by spinning disc confocal microscopy and processed using ImageJ. The image was acquired at the 2025 MBL Embryology course by Arthur Boutillon and was the Editor's choice from the Node image competition.

Congratulations to the winners of our image competition with the @mblscience.bsky.social Embryology course. The winner of the Editor’s choice is an image of a anole lizard eye, acquired by Arthur Boutillon @campaslab.bsky.social.
thenode.biologists.com/results-from...
#devbio 🔬🎉

🚨 Two weeks left to apply for the EMBL-EBI–Sanger Postdoctoral (ESPOD) Programme.

Apply by: 30 September 2025.

Ready to take the next step in your science career?
www.ebi.ac.uk/research/pos...

@sangerinstitute.bsky.social
#postdoc #sciencecareers

Phenotype rescue upon Zic4 and Gata3 double knockdown. (A,B) Maximum projection confocal images of oral (A) and aboral (B) ends of animals after GFP RNAi (control), Zic4 or Gata3 RNAi, and Zic4+Gata3 RNAi. DNA in cyan, peroxidase activity in magenta and Nematocilin in orange. Panels on the right show magnifications of boxed areas on the left. Scale bars: 100μm. Note the ectopic peroxidase staining in tentacle tips upon Zic4 RNAi, and ectopic Nematocilin staining adjacent to the foot upon Gata3 RNAi, as well as rescue of both phenotypes in the double knockdown. (C) Percentage of animals with ectopic peroxidase staining in tentacles upon Zic4 KD and double KD. (D) Percentage of animals with ectopic Nematocilin staining adjacent to the foot in Gata3 KD and double KD. For examples of strong and partial phenotypes refer to Fig. S6. Data in G and H shown for n animals pooled from at least two independent replicates. ***P<0.001 (Fisher's exact test). (E,F) Schematic of proposed model for controlling the choice between basal disk and battery cell fate in Hydra. At the oral pole, Wnt signaling (black dot) activates Zic4 (orange) expression and thus basal disk identity. Without it, Gata3 dominates at the opposite end, leading to basal disk fate establishment (E). Experimentally depleting one of the factors results in ectopic cell fate acquisition at the opposite body end (F).

Hydra body axis balance: a fight between two transcription factors

This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis:

journals.biologists.com/dev/article/...

Venez nombreux, pas besoin d’être millionaire pour aider la recherche. Peu importe le montant, chaque don sera bénéfique !

🙌🙌🙌

So many exciting projects !
Congrats all laureates!

Some will not like it but which papers are you taking with you this summer? Looking for good reads!

A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells A small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis ...

Impressive work from @josesilvalab.bsky.social

www.cell.com/cell/fulltex...

Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...

Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social

thenode.biologists.com/jobs/postdoc...

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Nice work @guandrey.bsky.social and @olimpiabompadre.bsky.social
Dev Bio is amazing !

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

C'est important les PHRC quand meme!

poke

Registration is now open!

Gastrulation Reloaded: Developing, engineering & evolving the body plan

📅 October 14–17, 2025
📍 Paris, France
🗓️ Abstract & early bird deadline: July 15, 2025

www.gastrulation-reloaded.conferences-pasteur.org/home

Exceptional lineup of speakers & many selected talks

🚨 Hey #gastrulation folks!

The early bird registration and the abstract submission are coming up very soon.

Please register now for this nice #conference in @pasteur.fr, it will be super cool!
👇👇👇

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Thanks to all the volunteers and partners who made this possible! Including @sfbd.bsky.social, @institutcurie.bsky.social and the city of Ivry-sur-Seine.

We have now 5 species sheets: Drosophila, nematode, zebrafish, arabidopsis and bombyx. Available in French and English, and soon in Greek.

This month marks the 3-year anniversary of En Quête de Bio outreach launch, created with @bardinlab.bsky.social and the support of the @sfbd.bsky.social !

By the end of the week, we'll have passed the 4,500-child milestone, done it in 16 cities, with the help of 72 volunteers!

www.eqd-bio.org

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#shapinglife3 was a great @sfbd.bsky.social meeting! Here's my short post on @the-node.bsky.social about it :)

Thanks @girishkalephd.bsky.social for this nice report on #ShapingLife3 It was a pleasure to meet and listen to you there!
@the-node.bsky.social @biologists.bsky.social @sfbd.bsky.social @ibdm.bsky.social

On the Shape of Life: meeting report, SFBD meeting 2025 - the Node Recently, I attended ‘Shaping Life 3’, the quadrennial meeting of the French Society of Developmental Biology (SFBD). The first of these meetings happened

On the Shape of Life: meeting report, SFBD meeting 2025

Girish Kale @girishkalephd.bsky.social wrote about his experience attending #ShapingLife3, the @sfbd.bsky.social meeting, which took place in the picturesque town of Cassis:

thenode.biologists.com/on-the-shape...

Bravo to the poster and best talk winners @sfbd.bsky.social #ShapingLife3: 3 PhD students: Romain Giromini, Étienne Poidomani and Noemi Zollo

This @sfbd.bsky.social conference had also an #outreach event in primary schools coordinated by @maevalux.bsky.social and 11 volunteers.

The amazing organization team of #ShapingLife3 meeting of @sfbd.bsky.social in sunny Cassis! Thanks to the great scientists for sharing their passion for embryos, and the beauty of life ! @maitrejl.bsky.social @cedricmaurange.bsky.social @maevalux.bsky.social @ibdm.bsky.social and others

A big thanks to the @sfbd.bsky.social , @maitrejl.bsky.social & @embo.org YIP for what has been a very sunny & exciting #DevBio + beautiful hikes around #Cassis.

& now everyone in there knows about #Ichthyosporea & #Expansion #Microscopy
Which is a big ➕️

#ShapingLife3

End of the #shapinglife3 meeting, full of cool #developmentalBiology. Thanks to all of the organizers for putting together a fantastic program. I hope to come back for the next iteration. Keeping fingers crossed for similar location (building on the left was the meeting venue) @sfbd.bsky.social