Mike Tadross

Excited to be joining a fantastic community of neuroscientists!

The lab is officially up & running at Duke! 🥳

Huge thanks to @dukemedschool.bsky.social for the amazing space, & to our lab team for getting everything installed & operational within a month 😅

Excited for what’s ahead!

Happy Birthday Dick Tsien! So happy to join former labmembers in celebration. Amazing to be reminded of the breath and depth of your contribution to science - with a strong flavor of "what is the underlying mechanism" @deisseroth.bsky.social @yulonglilab.bsky.social

Honored to speak at Tsien@80—a beautiful reminder that mentorship, curiosity, and generosity leave the deepest legacy. Thank you, Dick Tsien, for welcoming me into your scientific family. Happy 80th! 🎉 #DickTsien80

As an author on the paper Vinny skewers here, I say ouch and read this.

How Public Supported Studies Bring This Researcher and Patient Closer to a Cure for Alzheimer’s | Duke Today

Superb Duke piece on Alzheimer's Research:
today.duke.edu/2025/04/how-...

Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️
www.biorxiv.org/content/10.1...

U.S. BRAIN Initiative set to lose $81 million this year A government spending bill, approved today by the House of Representatives, allocates 20 percent less funding for the program than last year.

"This is a massive loss for neuroscience,” says Cory Miller.

By @avaskham.bsky.social

www.thetransmitter.org/funding/u-s-...

Still, while thrilled our 2 TTIs and 3 staff scientists were rescued, many other great scientists were terminated, incl lab and core staff

wtaf

Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...

🚨 New lab paper!🚨

A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social

We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇

www.nature.com/articles/s41...

Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...

Suthana et al. studied brain recordings from implanted electrodes in freely moving humans. They show that neural dynamics encoded actual and imagined routes similarly. @suthanalab.bsky.social @seeber.bsky.social
www.nature.com/articles/s41...

Universities are facing big cuts to research funding. At Duke, it's a time for 'damage control' Facing the potential loss of hundreds of millions of dollars in federal funding, Duke University is preparing for the worst.

apnews.com/article/trum...

YouTube video by mtadross Tadross WinterBrain

“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI

Same with general University functions. They think that taking away the words diversity, equity, and inclusion changes things. Libs love their labels (on that I agree 😅) so banning "DEI" will make us all cry. That's really their point, as juvenile as it is. But just live DEI, be it. Can't ban that.

Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.

Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).

1/n

YouTube video by mtadross Tadross WinterBrain

“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI

Seattle biotech startup Tune Therapeutics lands $175M to support clinical research Tune Therapeutics' co-founders, from left: Akira Matsuno, chief financial officer; Charles Gersbach; and Fyodor Urnov, who also serves on the startup's

Tune uses epigenetic editing to control gene expression without modifying the DNA sequence itself. The startup's technology is based on research from Tune co-founder and Duke BME Professor Charles Gersbach.

Received bad news about Carl Olson. Sad to hear that he passed away. Carl was a major influence on my early years as an Assistant Prof, with our labs down the hall from each other. He was a highly rigorous neurophysiologist, with a wry sense of humor. Please see attached images for more info.

Top, images of lipid stained expansion microscopy processed brain. Bottom, diagram of machine learning for brain activity prediction.

More catchup :) 2 bioRxiv preprints related to our goals of mapping and modeling entire brains: Dense Continuous Membrane Labeling and Expansion Microscopy..., synthneuro.org/publications... Scaling Properties for Artificial Neural Network Models of Entire C. elegans, synthneuro.org/publications...