Jani Huuhtanen MD PhD

We went to look for T cell specific responses in autoimmunity, but found NK cells instead. We studied aplastic anemia, one of the best characterized CD8+ T cell mediated AIDs with >200 samples with scRNA-seq, TCRseq, machine-learning; dig into the thread below (or Zenodo)!

28.02.2025 13:21 — 👍 2    🔁 0    💬 0    📌 0

Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...

There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem):
www.science.org/doi/10.1126/...

Here's my thread explaining this work🧵

20.12.2024 16:57 — 👍 237    🔁 70    💬 10    📌 9

Design of high specificity binders for peptide-MHC-I complexes Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance, and specific targeting of these peptide-MHC (pMHC) complexes could have consider...

Designing TCR that recognize pMHC is though ... what if we could bypass TCRs altogether? Innovative two new studies design and validate pMHC binders from scratch with generative modeling - congrats Baker/Garcia and Jensen/Hadrup labs

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

10.12.2024 05:22 — 👍 1    🔁 0    💬 0    📌 0

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

Our new work!

We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...

20.11.2024 09:55 — 👍 86    🔁 23    💬 4    📌 2