Benjamin Lau

What a great evening! And impressive line-up of #RNA scientists. #Science #Munich

11.12.2025 19:00 — 👍 3    🔁 0    💬 0    📌 0

Very excited to attend the award symposium of the 2025 Heinrich Wieland prize, where the award will be presented to Prof. Adrian R. Krainer for his work on RNA splicing and clinical breakthrough using ASO's (anti-sense oligos). #RNA #medsky #munich #munichresidence @boehringerglobal.bsky.social

11.12.2025 15:43 — 👍 1    🔁 0    💬 1    📌 0

Happy to have contributed to this cool story, check it out now in @natureportfolio.nature.com

rdcu.be/enJ8P

26.05.2025 13:39 — 👍 4    🔁 2    💬 0    📌 0

With the GPATCH1-DHX35 and TFIP11-DHX15 pairs present, our work opens intriguing questions regarding splicing fidelity. Special thanks to Reinhard Lührmann for guiding us ribosome folks!

28.02.2025 06:09 — 👍 3    🔁 0    💬 0    📌 0

Structures of aberrant spliceosome intermediates on their way to disassembly Nature Structural & Molecular Biology - Here, the authors provide insights into a splicing quality control mechanism. The Gpl1–Gih35 complex binds to the active site of aberrant...

Known to regulate splicing of pre-mRNAs with non-canonical splice sites, we provide fiery structural details into the action of GPATCH1-DHX35. Soni et al. reported similar insights from S. Pombe, suggesting a conserved route to mitigate a common source of error during splicing. rdcu.be/ebDtT

28.02.2025 06:09 — 👍 2    🔁 0    💬 1    📌 0

We identify catalytically active spliceosomes that were intercepted by quality control: they contain a suboptimal pre-mRNA that is recognized by the G-patch protein GPATCH1, which binds its cognate RNA helicase DHX35, while disassembly factors DHX15-TFIP11-GCFC2 bind nearby.

28.02.2025 06:09 — 👍 1    🔁 0    💬 1    📌 0

Splicing in C.t. is surprisingly similar to humans (expanding @hitenmadhani.bsky.social work to thermophiles): CryoEM structures of 𝑐𝑡spliceosomes with a core resolution of 2.2A (one of the best in the field🔥) are similar to recently published ones by the Plaschka and Cochella Labs rdcu.be/ebDt7

28.02.2025 06:09 — 👍 2    🔁 0    💬 1    📌 0

Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates Cell Research - Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates

Hot and splicy 🔥 Check out spliceosome complexes under quality control by GPATCH1-DHX35! We establish C. Thermophilum as serious player when it comes to spliceosomes. Great collaboration between the Hurt, Jingdong Cheng, Fei Xavier Chen and Lührmann labs. rdcu.be/ebBAx #spliceosome #somelikeithot

28.02.2025 06:09 — 👍 7    🔁 2    💬 1    📌 0