Nichollas Scott

Conventional proteomics searches struggle with many modifications and fully open searches may be difficult to interpret. We introduce a "detailed" mass offset search in #MSFragger boosting interpretability and localization especially in complex cases (e.g. FPOP data): www.biorxiv.org/content/10.1...

Alan Marshall: A scientist and a Gentleman - MagLab Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

The late-stage steps of Burkholderia cenocepacia protein O-linked glycan biosynthesis are conditionally essential Periplasmic O-linked protein glycosylation is a highly conserved process observed across the Burkholderia genus. Within Burkholderia, protein glycosylation requires the five-gene cluster known as the ...

Really nice to see this work finally out in print. This has been a long term project (> 3 years) in the lab to understand why we couldn't make a few mutants in the burkholderia o-linked glycan biosynthesis pathway. Special shout out to Leila who drove most of this work! www.jbc.org/article/S002...

Wait is that supposed to be a cid spectra (no charge reduction so doesn't look like a ExD)... I'm seeing z ions annotated...

📣 Calling all students! 📣

Did you know that ANZSMS have travel support for attending ANZSMS conferences and international mass spectrometry conferences? 😮

The deadline for students attending the 30th ANZSMS at AUS-oMicS this year is coming up next week, 18th March! 🚨

Congratulations!! Very well deserved!

ANSMS 2025 Medal Recipients. Morrison Medal, Prof Nicki Packer from Macquarie University. Bowie Medal, A/Prof Shane Ellis from University of Wollongong.

🎉Announcing our ANZSMS 2025 Medalists 🎉

Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!

Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆

Read about our medalists here 👉 mailchi.mp/6c90f3d41712...

Popularity of current DIA data analysis tools (vendor-independent, based on citations of initial publication) Updated for 2024:

Applications are open for the #FeMS+ 2025 Q2 Empowerment Awards! Thanks @brukercorporation.bsky.social for sponsoring!
Apply here: airtable.com/appyGufCIumj...
#TeamMAssSpec #WomenEmpowerment

Regardless of current events, highlighting trainees as they continue to excel is a joy.

We just added @emmajays.bsky.social's recent J_@asms.org publication about chemical deamidation from common proteomics buffer to our website, too.

Congrats Emmajay! #TeamMassSpec

pubs.acs.org/doi/full/10....

Really cool stuff, this looks super specific to cys. Looking at the ms2 data do labelled peptides show any unique diagnostic ions?

Ha! Not my only bright jersey on this trip

For those interested in the distance cycled, not bad considering there was two days of travel in there

I rarely post personal things on here but it's my birthday and as it's the big 4-0 I've spent the week cycling in south east Asia which has been awesome.. 100% recommend cycling around Siem Reap in Cambodia

⏰ Time’s ticking! Only 2 weeks left to submit your oral presentation abstract for #AUSoMicS 2025!

🗓️ Deadline: Jan 31st, 2025

Submit your abstract here: ausomics.com/abstracts

#metabolomics #proteomics #glycomics #massspectrometry #multiomics
@anzsms.bsky.social @ozglyco.bsky.social

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...

Polysialylation is a general feature of immune activation https://www.biorxiv.org/content/10.1101/2025.01.10.632476v1

not alot of tree cover in those photos but looks beautiful!

I’m looking for a postdoc with experience in #glycosyltransferases and/or yeast/insect #proteinexpression
A new EU pathfinder project begins on 1st February 2025.
Contact me if interested!

Oh man this hits way too close to me🤣

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...

Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...

An early Xmas present of a portrait of my puppy for my work office :)

The complete genome sequence of the crayfish pathogen Candidatus Paracoxiella cheracis n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of huma...

For my first Bluesky post … let me introduce you to Paracoxiella! This has been a fun adventure - shedding light on a mysterious Dot/Icm Coxiellaceae causing trouble for crayfish. A wonderful collaboration across rivers, states and oceans! www.biorxiv.org/content/10.1...

You could say this is cray-zie cool work, super fun work from @hayleyjnewton.bsky.social and co!

Research Fellow (eDNA in Biofilms) The Singapore Centre for Environmental Life Sciences Engineering (SCELSE) is a unique interdisciplinary Research Centre of Excellence (RCE), funded by National Research Foundation, Ministry of Educati...

I'm recruiting! I'm looking for a motivated postdoctoral scientist to join my new team at SCELSE in Singapore. The role will explore various aspects of how #eDNA is produced and utilised in #Pseudomonas aeruginosa biofilms.

#Microsky #phagesky #Science

ntu.wd3.myworkdayjobs.com/Careers/job/...

Registrations are open for AUS-oMicS, a joint meeting of Australasian Proteomics Society, @ozglyco.bsky.social, Australian & NZ Metabolomics Society and @anzsms.bsky.social . Registrations & abstract submissions are now open! #TeamMassSpec #massspectrometry www.ausomics.com

Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB - Nature Microbiology Identification of the entire set of genes needed for multi-drug plasmid IncC conjugation will inform efforts to prevent plasmid spread.

There is this nice study from mark schembri's lab where they used tradis to look at conjugation www.nature.com/articles/s41...

To be honest I am very ok with this, this gives people space to process outcomes by themselves without peers around and then make the call to take a day if needed.

The Late-Stage Steps of Burkholderia cenocepacia Protein O-Linked Glycan Biosynthesis Are Conditionally Essential. Periplasmic O-linked protein glycosylation is a highly conserved process observed across the Burkholderia genus. Within Burkholderia , protein glycosylation requires the five gene cluster known as the...

for my first bluesky post I'm happy to share a fun project from the lab we have been working on for a few years exploring the essentiality of genes involved in o-linked protein glycan biosynthesis in Burkholderia! www.biorxiv.org/content/10.1...

Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin Author summary Acinetobacter baumannii causes infections that are difficult to treat due to high rates of antibiotic resistance, leading the World Health Organization and CDC to classify this pathogen...

Happy to share our last publication. Diclofenac and colistin synergistically act against colistin-resistant A baumannii in mice at low concentration. They repress expression of type IV pili, causing an antivirulence effect! journals.plos.org/plospathogen...