Charles Bayly-Jones

Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.

This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉

Photography and video: @vicgovau.bsky.social

www.youtube.com/watch?v=9_Ht...

Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex Su et al. elucidated the cryo-EM structures of the CASTOR1-GATOR2, Sestrin2-GATOR2, and CASTOR1-Sestrin2-GATOR2 complexes. By integrating the structural findings with in vitro pull-down assays and HDX...

Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex www.cell.com/cell-reports...

Yes! Thank you, I've already been using it. Fantastic tool :)

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110

@lorneproteins.bsky.social Meeting with the Lorne Protein Committee to plan for the 2026 and future meetings!
@wehi-research.bsky.social

I think there is. If AF always gives the most favorable conformation, irrespective of how shallow the energy well is, then when only two proteins are present it gives a sort of minimally viable interface. When a 3rd protein is added, it must pick the preferred interface among 3 possible dimers. 1/2

This paper is absolutely bananas and a tour de force of structural bioinformatics. Some random tidbits:

MIC: A deep learning tool for assigning ions and waters in cryo-EM and crystal structures - Nature Communications In this work the authors develop a machine learning tool to classify spherical densities as ions and waters in provided x-ray crystallography and cryo-EM macromolecular structures. The method is valid...

Laura Shub and coauthors introduce MIC, a deep learning tool that accurately distinguishes ions from waters in cryo-EM and crystal structures, improving structural modeling and analysis in biology and drug discovery.
www.nature.com/articles/s41...

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

This tool is incredible! 🙏 Quick suggestion for the server, including the name (and species) of each match in the list would make it much easier to interpret. It's not straight forward to inspect the list of hits without opening dozens of tabs. 🎉

Nice review on #TSC and #mTORC highlighting our cryoEM structure of TSC. Phosphorylation mechanisms that modulate TSC activity still remain unknown. TBC1D7 function largely a mystery, but important in brain development / megalencephaly.

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

Structural motif search across the protein-universe with Folddisco https://www.biorxiv.org/content/10.1101/2025.07.06.663357v1

Zero-shot antibody design in a 24-well plate https://www.biorxiv.org/content/10.1101/2025.07.05.663018v1

Just try and get an animal to learn something truly arbitrary and unrelated to their evolutionary backbone - they will not be efficient learners. Not at all.

The mechanistic basis of cargo selection during Golgi maturation The multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a cons...

This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport.

The mechanistic basis of cargo selection during Golgi maturation

Taylor, Zubkov, Ciazynska et al.

doi.org/10.1101/2025...

❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX

Magellon GUI for cryoEM

Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Delighted to announce the release of Boltz-2, which demonstrates unprecedented accuracy in predicting structure and binding affinity! Congrats to Sara Passaro, @gcorso.bsky.social + @jeremywohlwend.bsky.social on this stunning achievement!
📄Paper: bit.ly/boltz2-pdf
💻Code: github.com/jwohlwend/bo...

How a $60m computer called MAVERIC could change Australia’s AI future A new supercomputer in Melbourne will give researchers the firepower to work on vast data sets in health, medicine and climate change.

Monash just got a huge upgrade - How a $60m computer called MAVERIC could change Australia’s AI future www.afr.com/technology/h...

AF truly is amazing - but I disagree re "protein folding". AF does not explain the levinthal paradox for example. Structure prediction, yes solved. Folding, not yet. Deepmind statements otherwise are hype / advertisement.

First day in the UK (after 10 odd years). Greggs is an instant favourite 👏. Instant anti-favourite is £3.9 for a coffee, oddly has the same effect as drinking a coffee, except that you walk away looking like deer in headlights.

Australia should pay attention to what Trump just did to Harvard Students who have made extraordinary sacrifices to study here are being accused of everything from housing shortage to driving inflation, writes Professor Mark Scott, Vice-Chancellor and President of ...

Australia should pay attention to what Trump did to Harvard.

Excellent piece from the VC of the University of Sydney.

It would be very popular for Labor to heavily invest in Uni Ed and Science (opposite Trump). Support international students and scientists.

www.sydney.edu.au/news-opinion...

International students, as well as our brilliant domestic students, are the bedrock of our research and innovation sector. They're valuable beyond words. We should welcome them arms wide open.

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors - Nature Communications Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the mole...

New study of calcitonin and amylin receptors bound to cagrilintide out of the labs of Denise Wootten & Patrick Sexton.

Work driven by Jason Cao, @bluesocks81.bsky.social, and Rachel Johnson, et al.
@ccemmp-outreach.bsky.social

Happy to have been involved 🎉

www.nature.com/articles/s41...

Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.

Congratulations @cellarchlab.com & @florentwaltz.bsky.social 🎉

Teeny tiny by day, bigly by night...