Karyn

It’s one good step but unless the multiyear funding is significantly diminished it will be another year of significant declines in funded grants.

MechanoEnhancer

Fibroblast
Matrix Stiffness 50 vs 1 kPa

👉Bulk RNAseq
👉On-plate Omni ATACseq (NO detachment required🤠) ▶️Anoikis mechanoenhancer (BMF)
👉HiCAR
👉CRSIPRi epigenomic editing

21.8% putative mechanoenhancers "skipped 5 or more genes"😎

#Science 2025
www.science.org/doi/10.1126/...

Congrats @erikherzog.bsky.social Really nice work

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

It would work!

So sorry. Bad streak

Apparently the postings are up for several NIH director positions. Deadlines between 11/14 and 11/21. hr.nih.gov/careers/care...

Thrilled to share our Creative Concepts paper published in Heart Rhythm on how the circadian clock gene Bmal1 mediates sex specific cardiac ion channel expression. authors.elsevier.com/a/1m1jJ5VtUy... @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social

One of the reasons I enjoy morning walks in my Gainesville neighborhood. Moms, a dad, young ones and the piebald.

NIH wants to hear from you. No really.

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs
grants.nih.gov/grants/guide...

Also be sure to read the instructions a Forms I SF424. These Fs will have the new format/review instructions so there are different components from the previous NOFOs.

Sherwood

If you're struggling to visualise mouse NMJs, we've got a protocol just for you!

bio-protocol.org/en/bpdetail?...

Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis

Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬

Cancer induced FoxP1 expression in muscle reprograms muscle clock output. Why does this matter? By co-opting normal clock output, FoxP1 is disrupting homeostatic pathways important for muscle health. We posit that this clock disruption could be a factor contributing to cachectic outcomes.

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Our 2026 PhD course is now open for registration🤩

@ismcopenhagen.bsky.social
Copenhagen, 5-7 October 2026

Musculoskeletal tissue regeneration – mechanisms and clinical perspectives

Exciting topics and expert teachers - come join us!

phdcourses.ku.dk/DetailKursus...

Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing Underlying many investments are breakthroughs in medicine and technology from great universities.

“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”

www.nytimes.com/2025/04/28/o...

Sorry that is lousy

Congratulations!!!!

I am happy to see 5 of the Regents of University of Michigan write this piece in support of university independence.

Happy birthday

I’m looking for a new research assistant! Please share with recent (or soon to be) graduates! www.linkedin.com/jobs/view/41...

Great talk!

@dadapisconti.bsky.social presenting her work on neutrophil elastase in muscle regeneration. Great science presented along with good humor

Awwww, just hang out more at UF

Well, some of us might think those cells hanging around - terminally differentiated ones like muscle fibers and neurons- provide a significant amount of continued identity.

Nice morning at La Chua trail with my muscle and clocks friends before the meeting starts. Jake Chen, Clara Peek and Mattia Q. Lots of gators out sunning themselves

Looking to conduct research in molecular biology and genetics? Come join the Kardon lab! Looking for lab tech to help research the role of stem cells in muscle development and regeneration and determine the effects of viral infection on muscle. Funding independent of federal resources. Please share!

Wish you were here!

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...