Emily Bruce

My dataset is that we couldn’t detect any positive SARS2 tests in any (of hundreds) of VT mammals we tested, so unfortunately in this case it does not require any complicated analysis 😂

The image features a message from Richard Hodge, a cancer editor at PLOS Biology, inviting submissions of primary research papers that offer novel insights into tumor progression and therapeutic contexts, displayed alongside the PLOS Biology logo and a photograph of Richard Hodge.

In this new #Biologue post, we speak to Richard Hodge, a cancer editor at #PLOSBiology about the new Collection “Unveiling cancer crosstalk across spatial and temporal scales”, his background in #CancerResearch and his vision for #cancer biology at the journal 🧪
plos.io/3U6GXFW

So apparently ADAR is downregulated in SINV inf, but heavily enriched in SARS2 RNPs (see also www.nature.com/articles/s41...). These are both RNA-interactome papers surveying binding partners in cells rather than virus

Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding pro…

ADAR does bind the genome- I wonder if you can work out where from their sequencing data...https://www.sciencedirect.com/science/article/pii/S109727652100407X?via%3Dihub

I thought there were some dsRNA regions outside of the ends..

Definitely. I was just hoping for a reason to explain specific editing at certain sites (though maybe its just that those ones form dsRNA)? I wonder if you could pull something out of the studies that mapped the RNA-RNA interactions of the genome back in 2020-2021...

Except if the rna is mostly made inside the DMV then ADAR won’t have access right?

If ADAR is editing RNA in the virion is it possible that these sequences are less shielded by nucleocapsid and so more accessible to editing? (i guess this could be true in cytoplasm too?)

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year

Chokes off billions in research funding

Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

Paylines suddenly go from 4% to 0%.

Tuberculosis - new warriors take on an old enemy TB has affected humans for centuries. In 2025, it is the number 1 infectious killer of humankind. We know how to control this disease, but have chosen not to. Four new books bring attention to this an...

TB is the # 1 infectious killer of humankind. We know how to control this disease, but have chosen not to.

New books by @johngreensbluesky.bsky.social @vidyakrishnan.bsky.social @mariasmilios.bsky.social & Handaa Enkh-Amgalan bring fresh advocacy

communities.springernature.com/posts/tb-an-...

a bald man in a blue suit is making a face . ALT: a bald man in a blue suit is making a face .

Preprint on tandem split-GFP influenza viruses is now up! We strung 7 copies of GFP11 together to make a bright virus with minimal fitness defects. Fluorescence requires GFP1-10 from cells, so we made a few that are relevant for flu. See this fluorescent love story: www.biorxiv.org/cgi/content/...

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

So your VPR can say “good news, grant submissions are up over the last few months at the emergency town hall”

Hahah WHY?!

(Not serious, but I expect this to be the advice. Along with “apply to foundations”….along with everyone else, as if the paylines there will stay the same which is impossible)

Write more grants 😭

NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.

This Thursday I will present the entirety of my PhD work (and a little bit more on the side) at #ASV2025 @amersocvirology.bsky.social . Be sure to be there if you'd like to know what is the hidden message of the coronavirus N gene!

**JOBS ALERT**

The Virology Unit at @PasteurCambodia
hiring 1 Scientist and 2 Postdocs to join our fast-moving, field-connected, research-driven team on emerging viruses and zoonoses.

🧪🧬🥼🦠🔬🐓💉🦇😷

Limited time to apply — and we need people to start ASAP.**👇

Research assistant (postdoc level) in molecular virology, EU-funded project APPEAL (Montpellier, France) The research assistant with a PhD in molecular virology (RA, 'ingénieur de recherche' in French) will work on the Horizon Europe-funded APPEAL project involving 13 partners from 6 countries, including...

New job offer in the team! If you're an experienced virologist (with a PhD), join us to work on Horizon Europe-funded APPEAL project in the vibrant city of Montpellier, South of France! euraxess.ec.europa.eu/jobs/359640

Thank you! It was a long road.

Awarded. Non-fellowships only.

FIRST NOTICE OF AWARD!

I’m excited to announce that our manuscript entitled “Oropouche virus infects human trophoblasts and placenta explants “ has been published by Nature Communications!! @natcomms.nature.com @natureportfolio.nature.com

PLOS Biology Associate Editor- FTC UK-Remote

The @plosbiology.org team is growing!

If you have a background in plant mol cell bio, a keen interest in sustainability and planetary health & are looking to move away from the bench, this may be for you!

Please spread the word

1yr FTC, remote in the UK
job-boards.eu.greenhouse.io/plos/jobs/46...

“Viruses of Montpellier” by Ed Hutchinson

Back cover art in the #NSV25 program courtesy of @socialinfluenza.bsky.social

❤️

I will steal for my next assembly talk😂

NIH APPLICANTS:

Your application will be WITHDRAWN BEFORE REVIEW if you have an international collaboration and do not include a Foreign Justification.

Normally this could be provided after review as JIT but NOT ANYMORE.

You have been warned.

Convergent evolution in nucleocapsid facilitated SARS-CoV-2 adaptation for human infection | Journal of Virology After its emergence, SARS-CoV-2 rapidly adapted to human infection, acquiring numerous mutations across its genome. Many of these mutations remain uncharacterized. This study examines a mutational hot...

2 in a row in the Journal of Virology.

A new paper from our group & the new Johnson lab at UTMB.

Here, we find multiple variant mutations in the SR rich domain of N facilitate improved infection with #SARS2.

A brief thread since this didn't get preprinted

journals.asm.org/doi/10.1128/...