Bonnie Lee

Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial AbstractBackground and Aims. Recent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients witho

Do we really need to do research specifically on women's health?

The REBOOT trial finds beta-blockers - a standard therapy for heart attacks - causes harm in women, but not men.

Yes.

The answer is yes.

academic.oup.com/eurheartj/ar...

✨ New Publication Feature ✨ How you take #menopausal #hormonetherapy may shape its impact on #cognition.

A new study by Puri et al. from @liisagalea.bsky.social's group shows route of estradiol administration and cognitive domain matter.

Learn more from the full paper here: 📖 ow.ly/ohlF50WNJiU

We’ve been working hard in the lab to understand the translational links to our preclinical work. Here’s our latest in preprint (& long time in process so many people to thank) but for now kudos to @bonniee-leee.bsky.social www.researchsquare.com/article/rs-7...

US POINTER study showed a significant improvement in global cognition for a structured intervention (physical, social, and cognitive activities, MIND diet, health monitoring) compared to self-guided intervention equivalent to 1-2 years of aging #AAIC2025. Evidence that behavior change can work

doi.org/10.1016/j.bb...
We found paradoxical effects of a previous pregnancy on the middle-aged brain depending on APOEe4 (genetic risk for late-onset Alzheimer’s disease) 🐁

I’ll be presenting some of this work and a follow-up study on Mon at 2pm during our FRS symposium at #AAIC25! Come say hi!! 👋

Really honoured to receive the @istaart.bsky.social Sex and Gender PIA Publication of the Year Award 🌟 Thank you to the PIA & @bucklr01.bsky.social!

And ofc a big thank you to my co-authors, collaborators, & importantly, my supervisor @liisagalea.bsky.social 🙌 #endALZ @alzassociation.bsky.social

Looking forward to #AAIC2025!! Hope to see many of you there 🤩

Had a great time presenting my latest work on effects of pregnancy and AD risk on functional connectivity in middle age at #OSSD2025 🧠⚡️

Thank you @ossdcomm.bsky.social @whrcluster.bsky.social @camhnews.bsky.social #womenmind for hosting this fantastic Pre-Meeting and the opportunity to speak!!

Greetings from Albuquerque, New Mexico! We are ready for the @ossdcomm.bsky.social meeting!
w/ @liisagalea.bsky.social @travisehodges.bsky.social @bonniee-leee.bsky.social

Ahhh!! Congrats to us 😜🥹

The end of a chapter.. 🥹💙 Endless thank yous to everyone who has been a part of this journey - lab mates and friends, other graduate students, mentors, collaborators, and of course, my supervisor, @liisagalea.bsky.social, for the support and mentorship over the years. #PhDone !!!!!! 👩🏻‍🎓

Congrats Jenn!!! 🥳

Women and gender-diverse communities are facing renewed challenges as recent policy changes threaten access to healthcare and research support. Our latest blog explores how past advocacy efforts can guide us through today’s setbacks.

📖 Full blog: ow.ly/8RfJ50VylCo

Parity and APOEε4 genotype contribute distinct changes to functional connectivity across the middle-aged brain Cognition and its underlying neurobiology change throughout the trajectory of aging, with prominent sex differences and influences of sex-specific factors. Research has shown that parity (pregnancy an...

I’m behind on sharing preprints because of …the rise of fascism but we need to celebrate wins. Here is @bonniee-leee.bsky.social ‘s last (but not least) paper of her PhD! On functional connectivity differences in middle-aged females based on parity and genotype! www.biorxiv.org/content/10.1...

Join us for a Multidisciplinary Look at Menopause!
🗓️ April 28 – 1:00 PM EST

Hear insights from the next generation of menopause researchers!
🔗 Reserve your spot today for this hybrid event: ow.ly/T8g350VpOap
#MenopauseResearch

Did you know that APOEe4, a genetic risk factor late-onset sporadic #AlzheimersDisease (AD) affects brain aging differently in males and females? 🧠 👀

📲 Swipe to learn more about this new study led by @bonniee_leee and click here to read the full paper: bsd.biomedcentral.com/articles/10....

Thank you!! 😊

Beyond grateful to everyone who has been part of this incredible journey 🩷✨

Women's research remains underrepresented in scientific studies. That's why CAMH womenmind™ is committed to closing the gender gap in research with 30+ grants & awards distributed to advance women in science and research 💜.

MORE:
www.camh.ca/en/get-invol...

#IDWGIS2025

But... is this really the whole picture? What if our current understanding is biased toward knowledge from male models?

This work highlights the urgent need to examine how and why AD develops differently across sex. Understanding these differences will lead to better, more effective treatments.

This latest study reveals that male rats with a genetic risk for AD show changes in markers related to brain health that "make sense" - reduced neural stem cells and neurogenesis, which was associated with increased microglia - yet female rats showed completely different patterns of effects.

Alzheimer’s disease (AD) disproportionately affects females, yet most research has focused on male models or not investigated the potential influences of sex. This has left critical gaps in our understanding of how AD risk and progression might be different across sexes.

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats - Biology of Sex Differences Background Alzheimer’s disease (AD) disproportionately and uniquely affects females, and these sex differences are further exacerbated by the presence of Apolipoprotein (APOE) ε4 alleles, the top gene...

New publication from my PhD research looking at influences of sex on brain health outcomes in a rodent model of Alzheimer’s disease (AD) risk 🎉: link.springer.com/article/10.1...

Big thank you to the best co-authors, @liisagalea.bsky.social, Melike Cevizci, and Stephanie Lieblich 🙏

Check out the full statement by Dr. Liisa Galea on our website: womenshealthresearchcluster.com/learn/womens...

A group of international early career researchers wearing purple tee shirts and holding cut out signs reading “AAIC” and “ISTAART”

Applications are now open for the ISTAART Ambassador Program 2025-26!

This program offers early-career researchers access to #AAIC25, as well as year-round training, networking, and mentoring opportunities.

Apply by Feb 10, 2025, at alz.org/ISTAARTambassadors!

A mouse hippocampus labeled for oligodendrocytes 🟡, myelin 🔵, and nuclei ⚪️. You can appreciate how the distribution of myelin and oligodendrocytes is not homogeneous in the overall hippocampal formation.

#FluorescenceFriday

Thank you so much! 😊

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

I’d like to be added! ☺️

Thanks so much Justin! So glad to hear you enjoyed it 😊 Happy to chat to you about sex/gender and neurogenesis anyyyyytime 🙌